Phospho-STAT5 (Tyr694) Monoclonal Antibody (SRBCZX), APC, eBioscience | Invitrogen 17-9010-41 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-STAT5 (Tyr694) Monoclonal Antibody (SRBCZX), APC, eBioscience

catalog :

17-9010-41

quantity :

25 Tests

price :

US 152

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

SRBCZX

reactivity :

human, mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 7l	Mitroulis I, Ruppova K, Wang B, Chen L, Grzybek M, Grinenko T, et al. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018;172:147-161.e12 pubmed publisher
	Hwang J, Holland J, Valenteros K, Sun Y, Usherwood Y, Veríssimo A, et al. Dissociating STAT4 and STAT5 Signaling Inhibitory Functions of SOCS3: Effects on CD8 T Cell Responses. Immunohorizons. 2019;3:547-558 pubmed publisher
	Fan M, Low J, Tanimine N, Finn K, Priyadharshini B, Germana S, et al. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. Cell Rep. 2018;25:1204-1213.e4 pubmed publisher
	Ferrao R, Wallweber H, Lupardus P. Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation. elife. 2018;7: pubmed publisher
	Gilboa D, Haim Ohana Y, Deshet Unger N, Ben Califa N, Hiram Bab S, Reuveni D, et al. Erythropoietin enhances Kupffer cell number and activity in the challenged liver. Sci Rep. 2017;7:10379 pubmed publisher
	Schröder M, Loos S, Naumann S, Bachran C, Krötschel M, Umansky V, et al. Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening. Oncoimmunology. 2017;6:e1258503 pubmed publisher
	Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel M, et al. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016;7:292-305 pubmed publisher
	Fu R, Ding S, Liu Y, Li L, Liu H, Wang H, et al. Expression and function of hematopoiesis-stimulating factor receptors on the GPI- and GPI+ hematopoietic stem cells of patients with paroxysmal nocturnal hemoglobinuria/aplastic anemia syndrome. Exp Ther Med. 2016;11:1668-1672 pubmed
	Ezeh P, Xu H, Lauer F, Liu K, Hudson L, Burchiel S. Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells. Toxicol Sci. 2016;149:289-99 pubmed publisher
	Timblin G, Schlissel M. Ebf1 and c-Myb repress rag transcription downstream of Stat5 during early B cell development. J Immunol. 2013;191:4676-87 pubmed publisher
	Mahmud S, Manlove L, Farrar M. Interleukin-2 and STAT5 in regulatory T cell development and function. JAKSTAT. 2013;2:e23154 pubmed publisher
	Gatzka M, Piekorz R, Moriggl R, Rawlings J, Ihle J. A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling. Cytokine. 2006;34:143-54 pubmed

product information

Product Type :

Antibody

Product Name :

Phospho-STAT5 (Tyr694) Monoclonal Antibody (SRBCZX), APC, eBioscience

Catalog # :

17-9010-41

Quantity :

25 Tests

Price :

US 152

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 5 µL (0.25 µg)/test

Species :

Human, Mouse

Clone :

SRBCZX

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.25 µg)/test

Aliases :

AA959963; mammary gland factor; mammary gland factor STAT5A; mammary gland factor; transcription factor; Mgf; Mpf; signal transducer and activator of transcription 5; signal transducer and activator of transcription 5a; signal transducer and activator of transcription factor 5A; STAT; STAT5; STAT5A; STAT5A, Mammary Gland Factor; STAT5A/MGF; STAT5B; STATA5

more info or order :

Invitrogen product webpage