product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-4 Monoclonal Antibody (11B11), APC, eBioscience
catalog :
17-7041-81
quantity :
50 µg
price :
US 212
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
11B11
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 234
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s1c
Thiele Née Schrewe L, Guse K, Tietz S, Remlinger J, Demir S, Pedreiturria X, et al. Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis. J Neuroinflammation. 2020;17:9 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2b
Henriksson J, Chen X, Gomes T, Ullah U, Meyer K, Miragaia R, et al. Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation. Cell. 2019;176:882-896.e18 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s4c
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, et al. Sumoylation of RORγt regulates TH17 differentiation and thymocyte development. Nat Commun. 2018;9:4870 pubmed publisher
  • flow cytometry; mouse
De Fanis U, Mori F, Kurnat R, Lee W, Bova M, Adkinson N, et al. GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. Blood. 2007;109:4343-50 pubmed
Li D, Ou Q, Shen Q, Lu M, Xu J, Jin C, et al. Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response. Stem Cell Res Ther. 2023;14:281 pubmed publisher
Zhao J, Jia L, Tao Y, Zhao X, Yang J, Lu Y, et al. TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance. Inflamm Res. 2023;72:531-540 pubmed publisher
Liao W, Foo H, Tran T, Chai C, Wong W. Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function. Br J Pharmacol. 2023;180:1056-1071 pubmed publisher
Sun S, Li E, Zhao G, Tang J, Zuo Q, Cai L, et al. Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge. Biomaterials. 2023;292:121907 pubmed publisher
Cai W, Hu M, Li C, Wu R, Lu D, Xie C, et al. FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation. Autophagy. 2023;19:1144-1163 pubmed publisher
Wang Y, Yang H, Jia A, Wang Y, Yang Q, Dong Y, et al. Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer. elife. 2022;11: pubmed publisher
Zhang Y, Li F, Chen C, Li Y, Xie W, Huang D, et al. RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke. J Cereb Blood Flow Metab. 2022;42:952-965 pubmed publisher
Kalim K, Yang J, Modur V, Nguyen P, Li Y, Zheng Y, et al. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Front Immunol. 2021;12:726393 pubmed publisher
Makino A, Shibata T, Nagayasu M, Hosoya I, Nishimura T, Nakano C, et al. RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration. iScience. 2021;24:103201 pubmed publisher
Tsai S, Atai N, Cacciottolo M, Nice J, Salehi A, Guo C, et al. Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity. J Biol Chem. 2021;297:101266 pubmed publisher
Duan R, Yang C, Du T, Liu A, Wang A, Sun W, et al. Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway. J Neuroinflammation. 2021;18:145 pubmed publisher
Sangaletti S, Botti L, Gulino A, Lecis D, Bassani B, Portararo P, et al. SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis. iScience. 2021;24:102510 pubmed publisher
Chen E, Lee C, Thompson P, Wiest D, Anderson M, Zuniga Pflucker J. Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo. Cell Rep. 2021;35:109227 pubmed publisher
Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, et al. Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice. Nat Commun. 2021;12:2574 pubmed publisher
Chen J, Ding Y, Huang F, Lan R, Wang Z, Huang W, et al. Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells. Oncol Lett. 2021;21:409 pubmed publisher
Pang L, Yu P, Liu X, Fan Y, Shi Y, Zou S. Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice. Mol Med Rep. 2021;23: pubmed publisher
Skordos I, Demeyer A, Beyaert R. Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry. STAR Protoc. 2021;2:100351 pubmed publisher
Liu W, Zhou N, Liu Y, Zhang W, Li X, Wang Y, et al. Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells. Stem Cell Res Ther. 2021;12:153 pubmed publisher
Kawata K, Suzuki T, Ozawa K, Sekiguchi M. Features of T-cell subset composition in a D-galactose-induced senescence mouse model. Exp Anim. 2021;70:284-292 pubmed publisher
Shi Y, Fu Y, Zhang X, Zhao G, Yao Y, Guo Y, et al. Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer. Cancer Immunol Immunother. 2021;70:61-73 pubmed publisher
Mahata B, Pramanik J, van der Weyden L, Polanski K, Kar G, Riedel A, et al. Tumors induce de novo steroid biosynthesis in T cells to evade immunity. Nat Commun. 2020;11:3588 pubmed publisher
LUCAS B, White A, Cosway E, Parnell S, James K, Jones N, et al. Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells. Nat Commun. 2020;11:2198 pubmed publisher
Zhu F, Qiu T, Zhu S, Zhao K, Chen C, Qiao J, et al. TIRC7 inhibits Th1 cells by upregulating the expression of CTLA‑4 and STAT3 in mice with acute graft‑versus‑host disease. Oncol Rep. 2020;44:43-54 pubmed publisher
DiToro D, Harbour S, Bando J, Benavides G, Witte S, Laufer V, et al. Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity. Immunity. 2020;52:650-667.e10 pubmed publisher
Song Y, Xu J, Wang X, Yang Y, Bai X, Pang J, et al. Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection. Parasite. 2019;26:74 pubmed publisher
Lee C, Kwon H, Kang H, Kim Y, Nam J, Won Y, et al. Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses. JCI Insight. 2019;4: pubmed publisher
Huang J, Yue H, Jiang T, Gao J, Shi Y, Shi B, et al. IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model. Biol Open. 2019;8: pubmed publisher
Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9:5340 pubmed publisher
Pramanik J, Chen X, Kar G, Henriksson J, Gomes T, Park J, et al. Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation. Genome Med. 2018;10:76 pubmed publisher
Pang P, Zheng K, Wu S, Xü H, Deng L, Shi Y, et al. Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis. Evid Based Complement Alternat Med. 2018;2018:4923062 pubmed publisher
Brombacher T, De Gouveia K, Cruywagen L, Makena N, Booley F, Tamgue O, et al. Nippostrongylus brasiliensis infection leads to impaired reference memory and myeloid cell interference. Sci Rep. 2018;8:2958 pubmed publisher
Mamedov M, Scholzen A, Nair R, Cumnock K, Kenkel J, Oliveira J, et al. A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence. Immunity. 2018;48:350-363.e7 pubmed publisher
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Van Dyke M, Chaturvedi A, Hardison S, Leopold Wager C, Castro López N, Hole C, et al. Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes. Front Immunol. 2017;8:1359 pubmed publisher
Chu F, Hu Y, Zhou Y, Guo M, Lu J, Zheng W, et al. MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway. Clin Exp Immunol. 2017;: pubmed publisher
Valanparambil R, Tam M, Gros P, Auger J, Segura M, Gros P, et al. IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection. PLoS Pathog. 2017;13:e1006647 pubmed publisher
Lirussi D, Ebensen T, Schulze K, Trittel S, Durán V, Liebich I, et al. Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway. EBioMedicine. 2017;22:100-111 pubmed publisher
Lee M, Choi J, Lee S, Cho I. Oriental Medicine Samhwangsasim-tang Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Th1 Cell Responses and Upregulating Treg Cell Responses. Front Pharmacol. 2017;8:192 pubmed publisher
Movassagh H, Shan L, Mohammed A, Halayko A, Gounni A. Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma. J Immunol. 2017;198:1805-1814 pubmed publisher
Yuan M, Li D, An M, Li Q, Zhang L, Wang G. Rediscovering peritoneal macrophages in a murine endometriosis model. Hum Reprod. 2017;32:94-102 pubmed
Perobelli S, Mercadante A, Galvani R, Gonçalves Silva T, Alves A, Pereira Neves A, et al. G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way. J Immunol. 2016;197:3725-3734 pubmed
Qi X, Gurung P, Malireddi R, Karmaus P, Sharma D, Vogel P, et al. Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal Immunol. 2017;10:128-138 pubmed publisher
Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, et al. p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice. Eur J Immunol. 2016;46:212-22 pubmed publisher
Wolpert F, Happold C, Reifenberger G, Florea A, Deenen R, Roth P, et al. Interferon-β Modulates the Innate Immune Response against Glioblastoma Initiating Cells. PLoS ONE. 2015;10:e0139603 pubmed publisher
Becker P, Nörder M, Weissmann S, Ljapoci R, Erfle V, Drexler I, et al. Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes. Vaccines (Basel). 2014;2:581-600 pubmed publisher
Li X, Xu J, Lv Z, Wang J, Sun S, Zhu W, et al. Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice. Hum Vaccin Immunother. 2015;11:1735-43 pubmed publisher
Chen S, Smith B, Iype J, Prestipino A, Pfeifer D, Grundmann S, et al. MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation. Blood. 2015;126:103-12 pubmed publisher
Hashimoto Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, et al. Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2015;112:E2677-86 pubmed publisher
Simpson L, Patel S, Bhakta N, Choy D, Brightbill H, Ren X, et al. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014;15:1162-70 pubmed publisher
Platzer B, Baker K, Vera M, Singer K, Panduro M, Lexmond W, et al. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol. 2015;8:516-32 pubmed publisher
Bakocevic N, Claser C, Yoshikawa S, Jones L, Chew S, Goh C, et al. CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections. Eur J Immunol. 2014;44:1823-34 pubmed publisher
Schadler K, Crosby E, Zhou A, Bhang D, Braunstein L, Baek K, et al. Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1. Cancer Res. 2014;74:2171-81 pubmed publisher
Prajeeth C, Löhr K, Floess S, Zimmermann J, Ulrich R, Gudi V, et al. Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia. Brain Behav Immun. 2014;37:248-59 pubmed publisher
Kim S, Karasuyama H, Lopez A, Ouyang W, Li X, Le Gros G, et al. IL-4 Derived from Non-T Cells Induces Basophil- and IL-3-independent Th2 Immune Responses. Immune Netw. 2013;13:249-56 pubmed publisher
Adachi K, Osada Y, Nakamura R, Tamada K, Hamano S. Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection. PLoS ONE. 2013;8:e82698 pubmed publisher
Kim K, Srikanth S, Tan Y, Yee M, Jew M, Damoiseaux R, et al. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014;192:110-22 pubmed publisher
Farhadi N, Lambert L, Triulzi C, Openshaw P, Guerra N, Culley F. Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation. J Allergy Clin Immunol. 2014;133:827-35.e3 pubmed publisher
Nie Y, Chen Y, Mou Y, Weng L, Xu Z, Du Y, et al. Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma. PLoS ONE. 2013;8:e72411 pubmed publisher
Lee P, Puppi M, Schluns K, Yu Lee L, Dong C, Lacorazza H. The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. J Immunol. 2014;192:178-88 pubmed publisher
Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014;10:461-8 pubmed publisher
Mollo S, Zajac A, Harrington L. Temporal requirements for B cells in the establishment of CD4 T cell memory. J Immunol. 2013;191:6052-9 pubmed publisher
Nakanishi W, Yamaguchi S, Matsuda A, Suzukawa M, Shibui A, Nambu A, et al. IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. PLoS ONE. 2013;8:e78099 pubmed publisher
Wong L, HATFIELD J, Brown M. Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development. J Biol Chem. 2013;288:35170-9 pubmed publisher
Zhou Q, Hu Y, Howard O, Oppenheim J, Chen X. In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo. Cytokine. 2014;65:56-64 pubmed publisher
Boué J, Basso L, Cenac N, Blanpied C, Rolli Derkinderen M, Neunlist M, et al. Endogenous regulation of visceral pain via production of opioids by colitogenic CD4(+) T cells in mice. Gastroenterology. 2014;146:166-75 pubmed publisher
Murakami R, Denda Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS ONE. 2013;8:e73270 pubmed publisher
Gangaplara A, Massilamany C, Steffen D, Reddy J. Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201-216 prevents autoimmune uveoretinitis by acting as altered peptide ligand. J Neuroimmunol. 2013;263:98-107 pubmed publisher
Wu B, Zou Q, Hu Y, Wang B. Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice. Hum Vaccin Immunother. 2013;9:2133-41 pubmed publisher
Yousefi M, Duplay P. CD28 controls the development of innate-like CD8+ T cells by promoting the functional maturation of NKT cells. Eur J Immunol. 2013;43:3017-27 pubmed publisher
González García C, Bravo B, Ballester A, Gomez Perez R, Eguiluz C, Redondo M, et al. Comparative assessment of PDE 4 and 7 inhibitors as therapeutic agents in experimental autoimmune encephalomyelitis. Br J Pharmacol. 2013;170:602-13 pubmed publisher
Monk J, Hou T, Turk H, McMurray D, Chapkin R. n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells. J Nutr. 2013;143:1501-8 pubmed publisher
Debock I, Jaworski K, Chadlaoui H, Delbauve S, Passon N, Twyffels L, et al. Neonatal follicular Th cell responses are impaired and modulated by IL-4. J Immunol. 2013;191:1231-9 pubmed publisher
Yeh L, Miaw S, Lin M, Chou F, Shieh S, Chuang Y, et al. Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice. J Immunol. 2013;191:594-607 pubmed publisher
Ohta S, Imamura M, Xing W, Boyce J, Balestrieri B. Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol. 2013;190:5927-38 pubmed publisher
Kong F, Chen W, He S, Lin Z, Li X, Zhang X, et al. Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production. Acta Pharmacol Sin. 2013;34:921-9 pubmed publisher
Shin K, Chung H, Kim D, Hwang J, Lee S. Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma. Life Sci. 2013;92:1093-9 pubmed publisher
Barron L, Smith A, El Kasmi K, Qualls J, Huang X, Cheever A, et al. Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS ONE. 2013;8:e61961 pubmed publisher
Suzuki J, Kuwahara M, Tofukuji S, Imamura M, Kato F, Nakayama T, et al. A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus. PLoS ONE. 2013;8:e61785 pubmed publisher
Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M. Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol. 2013;43:1727-34 pubmed publisher
Natividad K, Junankar S, Mohd Redzwan N, Nair R, Wirasinha R, King C, et al. Interleukin-27 signaling promotes immunity against endogenously arising murine tumors. PLoS ONE. 2013;8:e57469 pubmed publisher
Ferreira I, Smyth D, Gaze S, Aziz A, Giacomin P, Ruyssers N, et al. Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis. Infect Immun. 2013;81:2104-11 pubmed publisher
Manzke N, Akhmetzyanova I, Hasenkrug K, Trilling M, Zelinskyy G, Dittmer U. CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells. J Virol. 2013;87:6306-13 pubmed publisher
Othy S, Hegde P, Topçu S, Sharma M, Maddur M, Lacroix Desmazes S, et al. Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1-mammalian target of rapamycin axis. J Immunol. 2013;190:4535-41 pubmed publisher
Helmersson S, Sundstedt A, Deronic A, Leanderson T, Ivars F. Amelioration of experimental autoimmune encephalomyelitis by the quinoline-3-carboxamide paquinimod: reduced priming of proinflammatory effector CD4(+) T cells. Am J Pathol. 2013;182:1671-80 pubmed publisher
Park S, Jing X, Gupta D, Dziarski R. Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J Immunol. 2013;190:3480-92 pubmed publisher
Faustino L, da Fonseca D, Takenaka M, Mirotti L, Florsheim E, Guereschi M, et al. Regulatory T cells migrate to airways via CCR4 and attenuate the severity of airway allergic inflammation. J Immunol. 2013;190:2614-21 pubmed publisher
Bronevetsky Y, Villarino A, Eisley C, Barbeau R, Barczak A, Heinz G, et al. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med. 2013;210:417-32 pubmed publisher
Yamamoto M, Seki Y, Iwai K, Ko I, Martin A, Tsuji N, et al. Ontogeny and localization of the cells produce IL-2 in healthy animals. Cytokine. 2013;61:831-41 pubmed publisher
Khan T, Wong E, Soni C, Rahman Z. Prolonged apoptotic cell accumulation in germinal centers of Mer-deficient mice causes elevated B cell and CD4+ Th cell responses leading to autoantibody production. J Immunol. 2013;190:1433-46 pubmed publisher
Wan W, Lionakis M, Liu Q, Roffe E, Murphy P. Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice. Cardiovasc Res. 2013;97:580-8 pubmed publisher
Monk J, Hou T, Turk H, Weeks B, Wu C, McMurray D, et al. Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis. PLoS ONE. 2012;7:e49739 pubmed publisher
Donaldson D, Apostolaki M, Bone H, Richards C, Williams N. The Escherichia coli heat-labile enterotoxin B subunit protects from allergic airway disease development by inducing CD4+ regulatory T cells. Mucosal Immunol. 2013;6:535-46 pubmed publisher
Ito H, Yan X, Nagata N, Aritake K, Katsumata Y, Matsuhashi T, et al. PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis. J Am Soc Nephrol. 2012;23:1797-809 pubmed publisher
Antvorskov J, Fundova P, Buschard K, Funda D. Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice. Immunology. 2013;138:23-33 pubmed publisher
Zhao D, Zhang M, Wang M, Liu B, Wang X, Yang J, et al. Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets. Immunobiology. 2013;218:602-8 pubmed publisher
Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin D, et al. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol. 2012;189:2584-96 pubmed publisher
Gangaplara A, Massilamany C, Brown D, Delhon G, Pattnaik A, Chapman N, et al. Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-?-reactive CD4 T cells in A/J mice. Clin Immunol. 2012;144:237-49 pubmed publisher
Shah H, Devera T, Rampuria P, Lang G, Lang M. Type II NKT cells facilitate Alum-sensing and humoral immunity. J Leukoc Biol. 2012;92:883-93 pubmed publisher
Besin G, Yousefi M, Saba I, Klinck R, Pandolfi P, Duplay P. Dok-1 overexpression promotes development of ?? natural killer T cells. Eur J Immunol. 2012;42:2491-504 pubmed publisher
Jung K, Kang M, Park C, Hyun Choi Y, Jeon Y, Park S, et al. Protective role of V-set and immunoglobulin domain-containing 4 expressed on kupffer cells during immune-mediated liver injury by inducing tolerance of liver T- and natural killer T-cells. Hepatology. 2012;56:1838-48 pubmed publisher
Carrier Y, Whitters M, Miyashiro J, LaBranche T, Ramon H, Benoit S, et al. Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. Eur J Immunol. 2012;42:1393-404 pubmed publisher
Lischke T, Hegemann A, Gurka S, Vu Van D, Burmeister Y, Lam K, et al. Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS. J Immunol. 2012;189:234-44 pubmed publisher
Kwon M, Ma J, Ding Y, Wang R, Sun Z. Protein kinase C-? promotes Th17 differentiation via upregulation of Stat3. J Immunol. 2012;188:5887-97 pubmed publisher
Zhong Y, Wang X, Ji Q, Mao X, Tang H, Yi G, et al. CD4+LAP + and CD4 +CD25 +Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE-/- mice. J Clin Immunol. 2012;32:1104-17 pubmed publisher
Ueda A, Zhou L, Stein P. Fyn promotes Th17 differentiation by regulating the kinetics of ROR?t and Foxp3 expression. J Immunol. 2012;188:5247-56 pubmed publisher
Pereira P, Boucontet L. Innate NKT?? and NKT?? cells exert similar functions and compete for a thymic niche. Eur J Immunol. 2012;42:1272-81 pubmed publisher
Sharma A, Chen Q, Nguyen T, Yu Q, Sen J. T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes. J Immunol. 2012;188:3859-68 pubmed publisher
McNamara J, Schramm C, Singh A, Secor E, Guernsey L, Lefrancois L, et al. Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway disease. Am J Pathol. 2012;180:1991-2000 pubmed publisher
Attridge K, Wang C, Wardzinski L, Kenefeck R, Chamberlain J, Manzotti C, et al. IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis. Blood. 2012;119:4656-64 pubmed publisher
Ramon H, Beal A, Liu Y, Worthen G, Oliver P. The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J Immunol. 2012;188:4023-31 pubmed publisher
Bai L, Constantinides M, Thomas S, Reboulet R, Meng F, Koentgen F, et al. Distinct APCs explain the cytokine bias of ?-galactosylceramide variants in vivo. J Immunol. 2012;188:3053-61 pubmed publisher
Inamine A, Sakurai D, Horiguchi S, Yonekura S, Hanazawa T, Hosokawa H, et al. Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells. Clin Immunol. 2012;143:170-9 pubmed publisher
Kadri N, Korpos E, Gupta S, Briet C, Löfbom L, Yagita H, et al. CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes. J Immunol. 2012;188:3138-49 pubmed publisher
Muller U, Piehler D, Stenzel W, Kohler G, Frey O, Held J, et al. Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Mucosal Immunol. 2012;5:299-310 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
IL-4 Monoclonal Antibody (11B11), APC, eBioscience
Catalog # :
17-7041-81
Quantity :
50 µg
Price :
US 212
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
11B11
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4delta2; interleukin 4 variant IL-4delta3; interleukin 4 variant IL-4int2A; interleukin 4 variant IL-4int3A; interleukin 4 variant IL-4int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA