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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-2 Monoclonal Antibody (MQ1-17H12), APC, eBioscience
catalog :
17-7029-82
quantity :
100 µg
price :
US 349
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
MQ1-17H12
reactivity :
human
application :
flow cytometry
more info or order :
citations: 60
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig s1g
Wang C, Edilova M, Wagar L, Mujib S, Singer M, Bernard N, et al. Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy. J Immunol. 2018;200:558-564 pubmed publisher
  • flow cytometry; human; fig s1
Teirlinck A, McCall M, Roestenberg M, Scholzen A, Woestenenk R, de Mast Q, et al. Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans. PLoS Pathog. 2011;7:e1002389 pubmed publisher
Xia B, Lin K, Wang X, Chen F, Zhou M, Li Y, et al. Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment. Mol Ther Oncolytics. 2023;30:86-102 pubmed publisher
Mettelman R, Souquette A, Van De Velde L, Vegesana K, Allen E, Kackos C, et al. Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology. Nat Immunol. 2023;24:1511-1526 pubmed publisher
C xf4 rte Real B, Arroyo Hornero R, Dyczko A, Hamad I, Kleinewietfeld M. Dissecting the role of CSF2RB expression in human regulatory T cells. Front Immunol. 2022;13:1005965 pubmed publisher
Jeong H, Kim S, Jung M, Noh J, Yoo J, Kim E, et al. Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection. Cell Rep Med. 2022;3:100764 pubmed publisher
Mudd P, Minervina A, Pogorelyy M, Turner J, Kim W, Kalaidina E, et al. SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans. Cell. 2022;185:603-613.e15 pubmed publisher
Koerber N, Priller A, Yazici S, Bauer T, Cheng C, Mijočević H, et al. Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents. Nat Commun. 2022;13:153 pubmed publisher
Ando M, Kondo T, Tomisato W, Ito M, Shichino S, Srirat T, et al. Rejuvenating Effector/Exhausted CAR T Cells to Stem Cell Memory-Like CAR T Cells By Resting Them in the Presence of CXCL12 and the NOTCH Ligand. Cancer Res Commun. 2021;1:41-55 pubmed publisher
Kathamuthu G, Kumar N, Moideen K, Menon P, Babu S. Decreased Frequencies of Gamma/Delta T Cells Expressing Th1/Th17 Cytokine, Cytotoxic, and Immune Markers in Latent Tuberculosis-Diabetes/Pre-Diabetes Comorbidity. Front Cell Infect Microbiol. 2021;11:756854 pubmed publisher
Alrubayyi A, Gea Mallorqu xed E, Touizer E, Hameiri Bowen D, Kopycinski J, Charlton B, et al. Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV. Nat Commun. 2021;12:5839 pubmed publisher
Wu B, Woo J, Vila P, Jew M, Leung J, Sun Z, et al. NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells. Cell Rep. 2021;36:109603 pubmed publisher
Asgari A, Lesyk G, Poitras E, Govindasamy N, Terry K, To R, et al. Platelets stimulate programmed death-ligand 1 expression by cancer cells: Inhibition by anti-platelet drugs. J Thromb Haemost. 2021;19:2862-2872 pubmed publisher
Preece R, Pavesi A, Gkazi S, Stegmann K, Georgiadis C, Tan Z, et al. CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity. Mol Ther Methods Clin Dev. 2020;19:149-161 pubmed publisher
Lim M, Kumaran E, Tan H, Lye D, Leo Y, Ooi E, et al. Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus. Front Immunol. 2018;9:2225 pubmed publisher
De Luca R, Kachel P, Kropivšek K, Snijder B, Manz M, Neri D. A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies. Protein Eng Des Sel. 2018;31:173-179 pubmed publisher
Claireaux M, Galperin M, Benati D, Nouel A, Mukhopadhyay M, Klingler J, et al. A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers. MBio. 2018;9: pubmed publisher
Carpier J, Zucchetti A, Bataille L, Dogniaux S, Shafaq Zadah M, Bardin S, et al. Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation. J Exp Med. 2018;215:1245-1265 pubmed publisher
Anuradha R, Munisankar S, Bhootra Y, Dolla C, Kumaran P, Nutman T, et al. Modulation of CD4+ and CD8+ T Cell Function and Cytokine Responses in Strongyloides stercoralis Infection by Interleukin-27 (IL-27) and IL-37. Infect Immun. 2017;85: pubmed publisher
Wu X, Zhang H, Xing Q, Cui J, Li J, Li Y, et al. PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients. Br J Cancer. 2014;111:1391-9 pubmed publisher
Shanmugasundaram U, Critchfield J, Pannell J, Perry J, Giudice L, Smith McCune K, et al. Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women. Am J Reprod Immunol. 2014;71:95-108 pubmed publisher
Covassin L, Jangalwe S, Jouvet N, Laning J, Burzenski L, Shultz L, et al. Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells. Clin Exp Immunol. 2013;174:372-88 pubmed publisher
Diedrich C, Mattila J, Flynn J. Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection. J Immunol. 2013;190:6320-8 pubmed publisher
Kamburova E, Koenen H, Borgman K, ten Berge I, Joosten I, Hilbrands L. A single dose of rituximab does not deplete B cells in secondary lymphoid organs but alters phenotype and function. Am J Transplant. 2013;13:1503-11 pubmed publisher
Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker R, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013;496:518-22 pubmed publisher
Smith M, Bastidas S, Karrer U, Oxenius A. Impact of antigen specificity on CD4+ T cell activation in chronic HIV-1 infection. BMC Infect Dis. 2013;13:100 pubmed publisher
Jaudszus A, Gruen M, Watzl B, Ness C, Roth A, Lochner A, et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. J Lipid Res. 2013;54:923-35 pubmed publisher
McArthur M, Sztein M. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013;146:140-52 pubmed publisher
Marin N, Paris S, Rojas M, Garcia L. Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB. Tuberculosis (Edinb). 2013;93:155-66 pubmed publisher
Alexander T, Sattler A, Templin L, Kohler S, Groß C, Meisel A, et al. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. Ann Rheum Dis. 2013;72:1549-58 pubmed publisher
Yang R, Kalogriopoulos N, Rakhmilevich A, Ranheim E, Seo S, Kim K, et al. Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention. J Immunol. 2012;189:2656-64 pubmed publisher
Chatterjee B, Smed Sorensen A, Cohn L, Chalouni C, Vandlen R, Lee B, et al. Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells. Blood. 2012;120:2011-20 pubmed publisher
Jaudszus A, Jahreis G, Schlörmann W, Fischer J, Kramer R, Degen C, et al. Vaccenic acid-mediated reduction in cytokine production is independent of c9,t11-CLA in human peripheral blood mononuclear cells. Biochim Biophys Acta. 2012;1821:1316-22 pubmed publisher
De Keersmaecker B, Allard S, Lacor P, Schots R, Thielemans K, Aerts J. Expansion of polyfunctional HIV-specific T cells upon stimulation with mRNA electroporated dendritic cells in the presence of immunomodulatory drugs. J Virol. 2012;86:9351-60 pubmed publisher
McArthur M, Sztein M. Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization. PLoS ONE. 2012;7:e38408 pubmed publisher
Roat E, De Biasi S, Bertoncelli L, Rompianesi G, Nasi M, Gibellini L, et al. Immunological advantages of everolimus versus cyclosporin A in liver-transplanted recipients, as revealed by polychromatic flow cytometry. Cytometry A. 2012;81:303-11 pubmed publisher
Khoo A, Koenen H, Chai L, Sweep F, Netea M, van der Ven A, et al. Seasonal variation in vitamin D? levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS ONE. 2012;7:e29250 pubmed publisher
Amarnath S, Mangus C, Wang J, Wei F, He A, Kapoor V, et al. The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Sci Transl Med. 2011;3:111ra120 pubmed publisher
Simhadri V, Mariano J, Zhou Q, DeBell K, Borrego F. Differential expression of CD300a/c on human TH1 and TH17 cells. BMC Immunol. 2011;12:62 pubmed publisher
Khoo A, Joosten I, Michels M, Woestenenk R, Preijers F, He X, et al. 1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells. Immunology. 2011;134:459-68 pubmed publisher
Vaccari M, Boasso A, Fenizia C, Fuchs D, Hryniewicz A, Morgan T, et al. Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade. J Virol. 2012;86:108-13 pubmed publisher
Neunkirchner A, Leb Reichl V, Schmetterer K, Mutschlechner S, Kueng H, Haiderer D, et al. Human TCR transgenic Bet v 1-specific Th1 cells suppress the effector function of Bet v 1-specific Th2 cells. J Immunol. 2011;187:4077-87 pubmed publisher
Karnell J, Karnell F, Stephens G, Rajan B, Morehouse C, Li Y, et al. Mycophenolic acid differentially impacts B cell function depending on the stage of differentiation. J Immunol. 2011;187:3603-12 pubmed publisher
Vinton C, Klatt N, Harris L, Briant J, Sanders Beer B, Herbert R, et al. CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus. J Virol. 2011;85:8702-8 pubmed publisher
Lakhashe S, Velu V, Sciaranghella G, Siddappa N, Dipasquale J, Hemashettar G, et al. Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine. 2011;29:5611-22 pubmed publisher
d Hennezel E, Yurchenko E, Sgouroudis E, Hay V, Piccirillo C. Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells. J Immunol. 2011;186:6788-97 pubmed publisher
Hrdinka M, Dráber P, Stepanek O, Ormsby T, Otahal P, Angelisova P, et al. PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis. J Biol Chem. 2011;286:19617-29 pubmed publisher
Mattila J, Diedrich C, Lin P, Phuah J, Flynn J. Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation. J Immunol. 2011;186:3527-37 pubmed publisher
Schmetterer K, Haiderer D, Leb Reichl V, Neunkirchner A, Jahn Schmid B, Küng H, et al. Bet v 1-specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1-specific T-cell effector function in an activation-dependent manner. J Allergy Clin Immunol. 2011;127:238-45, 245.e1-3 pubmed publisher
Kannanganat S, Nigam P, Velu V, Earl P, Lai L, Chennareddi L, et al. Preexisting vaccinia virus immunity decreases SIV-specific cellular immunity but does not diminish humoral immunity and efficacy of a DNA/MVA vaccine. J Immunol. 2010;185:7262-73 pubmed publisher
Bratke K, Klein C, Kuepper M, Lommatzsch M, Virchow J. Differential development of plasmacytoid dendritic cells in Th1- and Th2-like cytokine milieus. Allergy. 2011;66:386-95 pubmed publisher
Apetrei C, Gaufin T, Gautam R, Vinton C, Hirsch V, Lewis M, et al. Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinction. J Infect Dis. 2010;202 Suppl 3:S371-6 pubmed publisher
Llanos Cuentas A, Calderon W, Cruz M, Ashman J, Alves F, Coler R, et al. A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with sodium stibogluconate for the treatment of mucosal leishmaniasis. Vaccine. 2010;28:7427-35 pubmed publisher
Narayanan S, Silva R, Peruzzi G, Alvarez Y, Simhadri V, DeBell K, et al. Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS ONE. 2010;5:e10636 pubmed publisher
Golding A, Rosen A, Petri M, Akhter E, Andrade F. Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses. Immunology. 2010;131:107-17 pubmed publisher
Gordon S, Weissman A, Cecchinato V, Fenizia C, Ma Z, Lee T, et al. Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques. J Virol. 2010;84:3043-58 pubmed publisher
Jeffery L, Burke F, Mura M, Zheng Y, Qureshi O, Hewison M, et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 2009;183:5458-67 pubmed publisher
Beriou G, Costantino C, Ashley C, Yang L, Kuchroo V, Baecher Allan C, et al. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009;113:4240-9 pubmed publisher
Mueller Y, Do D, Altork S, Artlett C, Gracely E, Katsetos C, et al. IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses. J Immunol. 2008;180:350-60 pubmed
Swoboda R, Somasundaram R, Caputo L, Ochoa E, Gimotty P, Marincola F, et al. Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Cancer Res. 2007;67:3555-9 pubmed
product information
Product Type :
Antibody
Product Name :
IL-2 Monoclonal Antibody (MQ1-17H12), APC, eBioscience
Catalog # :
17-7029-82
Quantity :
100 µg
Price :
US 349
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Human
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Human
Clone :
MQ1-17H12
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA