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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), APC, eBioscience
catalog :
17-5971-82
quantity :
100 µg
price :
US 384
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
DX5
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 58
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...
Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562:605-609 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3h
Sockolosky J, Trotta E, Parisi G, Picton L, Su L, Le A, et al. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science. 2018;359:1037-1042 pubmed publisher
  • flow cytometry; mouse
Rubinstein M, Kovar M, Purton J, Cho J, Boyman O, Surh C, et al. Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}. Proc Natl Acad Sci U S A. 2006;103:9166-71 pubmed
Ro x17e mani x107 C, Lisni x107 B, Pribani x107 Mate x161 i x107 M, Mihali x107 A, Hir x161 l L, Park E, et al. Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nat Commun. 2023;14:6412 pubmed publisher
Kaur K, Bachus H, Lewis C, Papillion A, Rosenberg A, Ballesteros Tato A, et al. GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation. Cell Rep. 2021;37:110178 pubmed publisher
Gabriely G, Ma D, Siddiqui S, Sun L, Skillin N, Abou El Hassan H, et al. Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells. iScience. 2021;24:103347 pubmed publisher
Hosokawa H, Koizumi M, Masuhara K, Romero Wolf M, Tanaka T, Nakayama T, et al. Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells. J Exp Med. 2021;218: pubmed publisher
Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, et al. Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice. Nat Commun. 2021;12:2574 pubmed publisher
Wagner J, Wong P, Schappe T, Berrien Elliott M, Cubitt C, Jaeger N, et al. Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity. Cell Rep. 2020;31:107720 pubmed publisher
Huang A, Shinde P, Huang J, Senff T, Xu H, Margotta C, et al. Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells. JCI Insight. 2019;4: pubmed publisher
Walker J, Clark P, Crisp A, Barlow J, Szeto A, Ferreira A, et al. Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow. Immunity. 2019;: pubmed publisher
Davies A, Kim H, González Cano R, Choi J, Back S, Roh S, et al. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell. 2019;176:716-728.e18 pubmed publisher
Mertens B, Cristina de Araujo Nogueira T, Topalis D, Stranska R, Snoeck R, Andrei G. Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice. Oncotarget. 2018;9:21978-22000 pubmed publisher
Nam J, Son S, Ochyl L, Kuai R, Schwendeman A, Moon J. Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer. Nat Commun. 2018;9:1074 pubmed publisher
Van Dyken S, Liang H, Naikawadi R, Woodruff P, Wolters P, Erle D, et al. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017;169:497-509.e13 pubmed publisher
Shivakumar P, Mizuochi T, Mourya R, Gutta S, Yang L, Luo Z, et al. Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia. JCI Insight. 2017;2:e88747 pubmed publisher
Yong C, John L, Devaud C, Prince M, Johnstone R, Trapani J, et al. A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer. Oncotarget. 2016;7:34582-98 pubmed publisher
Kober C, Weibel S, Rohn S, Kirscher L, Szalay A. Intratumoral INF-? triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer. Mol Ther Oncolytics. 2015;2:15009 pubmed publisher
Put K, Brisse E, Avau A, Imbrechts M, Mitera T, Janssens R, et al. IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis. PLoS ONE. 2016;11:e0150075 pubmed publisher
Li Z, Song Z, Meng C, Yang D, Yang Y, Peng J. IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure. Sci Rep. 2015;5:18159 pubmed publisher
Yong C, Westwood J, Schröder J, Papenfuss A, von Scheidt B, Moeller M, et al. Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice. PLoS ONE. 2015;10:e0140543 pubmed publisher
Krneta T, Gillgrass A, Chew M, Ashkar A. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Cell Mol Immunol. 2016;13:628-39 pubmed publisher
Squires J, Shivakumar P, Mourya R, Bessho K, Walters S, Bezerra J. Natural killer cells promote long-term hepatobiliary inflammation in a low-dose rotavirus model of experimental biliary atresia. PLoS ONE. 2015;10:e0127191 pubmed publisher
Mathenge E, Dean C, Clements D, Vaghar Kashani A, Photopoulos S, Coyle K, et al. Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model. Neoplasia. 2014;16:950-60 pubmed publisher
Rosenstein R, Bezbradica J, Yu S, Medzhitov R. Signaling pathways activated by a protease allergen in basophils. Proc Natl Acad Sci U S A. 2014;111:E4963-71 pubmed publisher
Reber L, Marichal T, Sokolove J, Starkl P, Gaudenzio N, Iwakura Y, et al. Contribution of mast cell-derived interleukin-1? to uric acid crystal-induced acute arthritis in mice. Arthritis Rheumatol. 2014;66:2881-91 pubmed publisher
Li J, Razumilava N, Gores G, Walters S, Mizuochi T, Mourya R, et al. Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J Clin Invest. 2014;124:3241-51 pubmed publisher
Lafferty E, Flaczyk A, Angers I, Homer R, d Hennezel E, Malo D, et al. An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes Immun. 2014;15:320-32 pubmed publisher
Martinu T, Kinnier C, Sun J, Kelly F, Nelson M, Garantziotis S, et al. Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease. PLoS ONE. 2014;9:e97951 pubmed publisher
Bullard D, Hu X, Crawford D, McDonald K, Ramos T, Barnum S. Expression of a single ICAM-1 isoform on T cells is sufficient for development of experimental autoimmune encephalomyelitis. Eur J Immunol. 2014;44:1194-9 pubmed publisher
Rubinstein M, Salem M, Doedens A, Moore C, Chiuzan C, Rivell G, et al. G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses. J Hematol Oncol. 2013;6:75 pubmed publisher
Bulliard Y, Jolicoeur R, Windman M, Rue S, Ettenberg S, Knee D, et al. Activating Fc ? receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med. 2013;210:1685-93 pubmed publisher
Doyle A, Jacobsen E, Ochkur S, McGarry M, Shim K, Nguyen D, et al. Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice. Blood. 2013;122:781-90 pubmed publisher
Rodriguez B, Blando J, Lansakara P D, Kiguchi Y, DiGiovanni J, Cui Z. Antitumor activity of tumor-targeted RNA replicase-based plasmid that expresses interleukin-2 in a murine melanoma model. Mol Pharm. 2013;10:2404-15 pubmed publisher
Doyle A, Jacobsen E, Ochkur S, Willetts L, Shim K, Neely J, et al. Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils. J Leukoc Biol. 2013;94:17-24 pubmed publisher
Shimamura M, Seleme M, Guo L, Saunders U, Schoeb T, George J, et al. Ganciclovir prophylaxis improves late murine cytomegalovirus-induced renal allograft damage. Transplantation. 2013;95:48-53 pubmed publisher
Goulding J, Bogue R, Tahiliani V, Croft M, Salek Ardakani S. CD8 T cells are essential for recovery from a respiratory vaccinia virus infection. J Immunol. 2012;189:2432-40 pubmed publisher
Seedhom M, Mathurin K, Kim S, Welsh R. Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders. J Virol. 2012;86:6010-22 pubmed publisher
Heiber J, Barber G. Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent. J Virol. 2011;85:10440-50 pubmed publisher
Duraffour S, Matthys P, van den Oord J, De Schutter T, Mitera T, Snoeck R, et al. Study of camelpox virus pathogenesis in athymic nude mice. PLoS ONE. 2011;6:e21561 pubmed publisher
Becker M, Reuter S, Friedrich P, Doener F, Michel A, Bopp T, et al. Genetic variation determines mast cell functions in experimental asthma. J Immunol. 2011;186:7225-31 pubmed publisher
Kastenmüller K, Wille Reece U, Lindsay R, Trager L, Darrah P, Flynn B, et al. Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. J Clin Invest. 2011;121:1782-96 pubmed publisher
Nel H, Hams E, Saunders S, Mangan N, Smith P, Atzberger A, et al. Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. J Immunol. 2011;186:4631-9 pubmed publisher
Xiong Z, Ohlfest J. Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors. J Immunother. 2011;34:264-9 pubmed publisher
Laszkiewicz A, Cebrat M, Miazek A, Kisielow P. Complexity of transcriptional regulation within the Rag locus: identification of a second Nwc promoter region within the Rag2 intron. Immunogenetics. 2011;63:183-7 pubmed publisher
Kinnier C, Martinu T, Gowdy K, Nugent J, Kelly F, Palmer S. Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant. Transpl Immunol. 2011;24:83-93 pubmed publisher
Tomihara K, Guo M, Shin T, Sun X, Ludwig S, Brumlik M, et al. Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells. J Immunol. 2010;184:6151-60 pubmed publisher
Pastorino S, Renganathan H, Caliva M, Filbert E, Opoku Ansah J, Sulzmaier F, et al. The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling. FASEB J. 2010;24:2818-28 pubmed publisher
Motz G, Eppert B, Wortham B, Amos Kroohs R, Flury J, Wesselkamper S, et al. Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease. J Immunol. 2010;184:4460-9 pubmed publisher
Piliponsky A, Chen C, Grimbaldeston M, Burns Guydish S, Hardy J, Kalesnikoff J, et al. Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice. Am J Pathol. 2010;176:926-38 pubmed publisher
Miyagi T, Lee S, Biron C. Intracellular staining for analysis of the expression and phosphorylation of signal transducers and activators of transcription (STATs) in NK cells. Methods Mol Biol. 2010;612:159-75 pubmed publisher
Petersen A, Heegaard P, Pedersen A, Andersen J, Sørensen R, Frøkiaer H, et al. Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice. BMC Microbiol. 2009;9:245 pubmed publisher
Cheung T, Oborne L, Steinberg M, Macauley M, Fukuyama S, Sanjo H, et al. T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. J Immunol. 2009;183:7286-96 pubmed publisher
Castillo E, Stonier S, Frasca L, Schluns K. Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation. J Immunol. 2009;183:4948-56 pubmed publisher
Wohler J, Barnum S. Nylon wool purification alters the activation of T cells. Mol Immunol. 2009;46:1007-10 pubmed publisher
Rubinstein M, Lind N, Purton J, Filippou P, Best J, McGhee P, et al. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood. 2008;112:3704-12 pubmed publisher
Belanger S, Tai L, Anderson S, Makrigiannis A. Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome. Genes Immun. 2008;9:509-21 pubmed publisher
Walsh K, Lodoen M, Edwards R, Lanier L, Lane T. Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease. J Virol. 2008;82:3021-30 pubmed
product information
Product Type :
Antibody
Product Name :
CD49b (Integrin alpha 2) Monoclonal Antibody (DX5), APC, eBioscience
Catalog # :
17-5971-82
Quantity :
100 µg
Price :
US 384
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 µg/test
Species :
Mouse
Clone :
DX5
Isotype :
IgM, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 µg/test
Aliases :
alpha 2 subunit of VLA-2 receptor; BDPLT9; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; DX5; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Itga2; platelet antigen Br; platelet glycoprotein GPIa; platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA2 receptor; VLA-2 receptor, alpha 2 subunit; VLA-2 subunit alpha; VLAA2
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA