FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), APC, eBioscience™ | Invitrogen 17-5899-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), APC, eBioscience™

catalog :

17-5899-41

quantity :

25 Tests

price :

US 239

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

AER-37 (CRA1)

reactivity :

human

application :

flow cytometry

citations: 9

Reference
Izadi D, Layton T, Williams L, McCann F, Cabrita M, Espirito Santo A, et al. Identification of TNFR2 and IL-33 as therapeutic targets in localized fibrosis. Sci Adv. 2019;5:eaay0370 pubmed publisher
Pennington L, Tarchevskaya S, Brigger D, Sathiyamoorthy K, Graham M, Nadeau K, et al. Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. Nat Commun. 2016;7:11610 pubmed publisher
Jiang A, Jiang J, Wei J, Guo M, Qin Y, Guo Q, et al. Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans-Infection of CD4+ T Cells. J Virol. 2015;90:2928-37 pubmed publisher
Jiang A, Jiang J, Guo M, Jin Y, Li Y, Wang J. Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viral trans-Infection of CD4+ T Cells. J Virol. 2015;89:8050-62 pubmed publisher
Loizou D, Enav B, Komlodi Pasztor E, Hider P, Kim Chang J, Noonan L, et al. A pilot study of omalizumab in eosinophilic esophagitis. PLoS ONE. 2015;10:e0113483 pubmed publisher
Platzer B, Baker K, Vera M, Singer K, Panduro M, Lexmond W, et al. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol. 2015;8:516-32 pubmed publisher
Voskamp A, Prickett S, Mackay F, Rolland J, O Hehir R. MHC class II expression in human basophils: induction and lack of functional significance. PLoS ONE. 2013;8:e81777 pubmed publisher
Radinger M, Jensen B, Kuehn H, Kirshenbaum A, Gilfillan A. Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood. Curr Protoc Immunol. 2010;Chapter 7:Unit 7.37 pubmed publisher
Platzer B, Fiebiger E. The signal peptide of the IgE receptor alpha-chain prevents surface expression of an immunoreceptor tyrosine-based activation motif-free receptor pool. J Biol Chem. 2010;285:15314-23 pubmed publisher

product information

Product Type :

Antibody

Product Name :

FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), APC, eBioscience™

Catalog # :

17-5899-41

Quantity :

25 Tests

Price :

US 239

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.125 µg)/test

Species :

Human

Clone :

AER-37 (CRA1)

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is a tetrameric complex consisting of one alpha, one ß and two additional subunits. The latter two are required for signal transduction activity. The Fc epsilonR1 complex plays an important role in triggering allergic responses, and the immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine, which are responsible for allergy symptoms, are released. The IgE receptor couples allergen and mast cells to initiate the inflammatory responses that are characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes-potent effectors of the hypersensitivity response.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.125 µg)/test

Aliases :

fc epsilon r1; Fc epsilon receptor Ia; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; Fc IgE receptor, alpha polypeptide; Fc receptor, IgE, high affinity I, alpha polypeptide; Fce1a; Fc-epsilon RI-alpha; fcepsilonri; FCER1A; FcERI; Fcr-5; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; RP11-550P17.3