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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD93 (AA4.1) Monoclonal Antibody (AA4.1), APC, eBioscience™
catalog :
17-5892-81
quantity :
50µg
price :
167.00 USD
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
AA4.1
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 68
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig s1
Levit Zerdoun E, Becker M, Pohlmeyer R, Wilhelm I, Maity P, Rajewsky K, et al. Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function. J Immunol. 2016;196:2348-60 pubmed publisher
  • flow cytometry; mouse; fig s4
Pylayeva Gupta Y, Das S, Handler J, Hajdu C, Coffre M, Koralov S, et al. IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia. Cancer Discov. 2016;6:247-55 pubmed publisher
  • flow cytometry; mouse; fig s4
Wong E, Soni C, Chan A, Domeier P, Shwetank -, Abraham T, et al. B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. J Immunol. 2015;194:4130-43 pubmed publisher
  • flow cytometry; mouse
Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, et al. IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. J Exp Med. 2014;211:2085-101 pubmed publisher
  • flow cytometry; mouse; fig s8b
Redecke V, Wu R, Zhou J, Finkelstein D, Chaturvedi V, High A, et al. Hematopoietic progenitor cell lines with myeloid and lymphoid potential. Nat Methods. 2013;10:795-803 pubmed publisher
Weng Q, Hu F, Zhang M, Dong Y, Lv C, Wang Y, et al. A protocol for generating induced T cells by reprogramming B cells in vivo. Cell Regen (Lond). 2018;7:7-15 pubmed publisher
Baptista B, Granato A, Canto F, Montalvão F, Tostes L, DE Matos Guedes H, et al. TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells. Front Immunol. 2018;9:2281 pubmed publisher
Lino A, Dang V, Lampropoulou V, Welle A, Joedicke J, Pohar J, et al. LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells. Immunity. 2018;49:120-133.e9 pubmed publisher
Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz V. TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK. J Exp Med. 2017;214:1269-1280 pubmed publisher
Cheng H, Ang H, A El Farran C, Li P, Fang H, Liu T, et al. Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors. Nat Commun. 2016;7:13396 pubmed publisher
Sabouri Z, Perotti S, Spierings E, Humburg P, Yabas M, Bergmann H, et al. IgD attenuates the IgM-induced anergy response in transitional and mature B cells. Nat Commun. 2016;7:13381 pubmed publisher
Jones D, Gaudette B, Wilmore J, Chernova I, Bortnick A, Weiss B, et al. mTOR has distinct functions in generating versus sustaining humoral immunity. J Clin Invest. 2016;126:4250-4261 pubmed publisher
Yoon Y, Storm K, Kamimae Lanning A, Goloviznina N, Kurre P. Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2-/- Hematopoietic Stem and Progenitor Cells. Stem Cell Reports. 2016;7:840-853 pubmed publisher
Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed publisher
Frenkel D, Zhang F, Guirnalda P, Haynes C, Bockstal V, Radwanska M, et al. Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells. PLoS Pathog. 2016;12:e1005733 pubmed publisher
Feldman E, Kara M, Oko L, Grau K, Krueger B, Zhang J, et al. A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency. mSphere. 2016;1: pubmed
Pedersen G, Ádori M, Stark J, Khoenkhoen S, Arnold C, Beutler B, et al. Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens. Front Immunol. 2016;7:65 pubmed publisher
Yabas M, Jing W, Shafik S, Bröer S, Enders A. ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes. PLoS ONE. 2016;11:e0146774 pubmed publisher
Jones D, Wilmore J, Allman D. Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells. J Immunol. 2015;195:4753-9 pubmed publisher
Nadrah K, Beck T, Pereira J. Immature B Cell Egress from Bone Marrow Is SOCS3 Independent. PLoS ONE. 2015;10:e0136061 pubmed publisher
Jacque E, Schweighoffer E, Tybulewicz V, Ley S. BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. J Exp Med. 2015;212:883-92 pubmed publisher
Mills R, Lam V, Tan A, Cresalia N, Oksenberg N, Zikherman J, et al. Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production. J Immunol. 2015;194:3675-86 pubmed publisher
Kleiman E, Salyakina D, de Heusch M, Hoek K, Llanes J, Castro I, et al. Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen. Front Immunol. 2015;6:30 pubmed publisher
Pawaria S, Moody K, Busto P, Nündel K, Choi C, Ghayur T, et al. Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands. J Immunol. 2015;194:1403-7 pubmed publisher
Granato A, Hayashi E, Baptista B, Bellio M, Nobrega A. IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints. J Immunol. 2014;192:5761-75 pubmed publisher
Vanoaica L, Richman L, Jaworski M, Darshan D, Luther S, Kühn L. Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations. PLoS ONE. 2014;9:e89270 pubmed publisher
Coleman C, McGraw J, Feldman E, Roth A, Keyes L, Grau K, et al. A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo. PLoS Pathog. 2014;10:e1003916 pubmed publisher
Stessman H, Mansoor A, Zhan F, Linden M, Van Ness B, Baughn L. Bortezomib resistance can be reversed by induced expression of plasma cell maturation markers in a mouse in vitro model of multiple myeloma. PLoS ONE. 2013;8:e77608 pubmed publisher
Zhang Q, Esplin B, Iida R, Garrett K, Huang Z, Medina K, et al. RAG-1 and Ly6D independently reflect progression in the B lymphoid lineage. PLoS ONE. 2013;8:e72397 pubmed publisher
Ota T, Doyle Cooper C, Cooper A, Doores K, Aoki Ota M, Le K, et al. B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates. J Immunol. 2013;191:3179-85 pubmed publisher
Zhang Y, Guan Z, Reader B, Shawler T, Mandrekar Colucci S, Huang K, et al. Autonomic dysreflexia causes chronic immune suppression after spinal cord injury. J Neurosci. 2013;33:12970-81 pubmed publisher
Song J, Lokmic Z, Lämmermann T, Rolf J, Wu C, Zhang X, et al. Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proc Natl Acad Sci U S A. 2013;110:E2915-24 pubmed publisher
Chen Y, Zhang J, Hwang K, Bouton Verville H, Xia S, Newman A, et al. Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. J Immunol. 2013;191:1260-75 pubmed publisher
Vink P, Smout W, Driessen Engels L, de Bruin A, Delsing D, Krajnc Franken M, et al. In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation. PLoS ONE. 2013;8:e57348 pubmed publisher
Sun B, Mallampati S, Gong Y, Wang D, Lefebvre V, Sun X. Sox4 is required for the survival of pro-B cells. J Immunol. 2013;190:2080-9 pubmed publisher
Subrahmanyam R, Du H, Ivanova I, Chakraborty T, Ji Y, Zhang Y, et al. Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions. Nat Immunol. 2012;13:1205-12 pubmed publisher
Yu M, Chen Y, He Y, Podd A, Fu G, Wright J, et al. Critical role of B cell lymphoma 10 in BAFF-regulated NF-?B activation and survival of anergic B cells. J Immunol. 2012;189:5185-93 pubmed publisher
Siggs O, Li X, Xia Y, Beutler B. ZBTB1 is a determinant of lymphoid development. J Exp Med. 2012;209:19-27 pubmed publisher
Shen S, Manser T. Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing. J Immunol. 2012;188:47-56 pubmed publisher
Duong B, Ota T, Aoki Ota M, Cooper A, Ait Azzouzene D, VELA J, et al. Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape. J Immunol. 2011;187:5596-605 pubmed publisher
Vu T, Gatto D, Turner V, Funnell A, Mak K, Norton L, et al. Impaired B cell development in the absence of Krüppel-like factor 3. J Immunol. 2011;187:5032-42 pubmed publisher
Todd E, Deady L, Morley S. The actin-bundling protein L-plastin is essential for marginal zone B cell development. J Immunol. 2011;187:3015-25 pubmed publisher
Bockstal V, Guirnalda P, Caljon G, Goenka R, Telfer J, Frenkel D, et al. T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis. PLoS Pathog. 2011;7:e1002089 pubmed publisher
Bockstal V, Geurts N, Magez S. Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice. J Parasitol Res. 2011;2011:534697 pubmed publisher
Nikbakht N, Migone T, Ward C, Manser T. Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments. J Immunol. 2011;187:37-46 pubmed publisher
Venkatesh J, Yoshifuji H, Kawabata D, Chinnasamy P, Stanevsky A, Grimaldi C, et al. Antigen is required for maturation and activation of pathogenic anti-DNA antibodies and systemic inflammation. J Immunol. 2011;186:5304-12 pubmed publisher
Ota T, Ota M, Duong B, Gavin A, Nemazee D. Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing. J Exp Med. 2011;208:617-29 pubmed publisher
Gardam S, Turner V, Anderton H, Limaye S, Basten A, Koentgen F, et al. Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response. Blood. 2011;117:4041-51 pubmed publisher
Bossen C, Tardivel A, Willen L, Fletcher C, Perroud M, Beermann F, et al. Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses. Eur J Immunol. 2011;41:787-97 pubmed publisher
Racine R, McLaughlin M, Jones D, Wittmer S, MacNamara K, Woodland D, et al. IgM production by bone marrow plasmablasts contributes to long-term protection against intracellular bacterial infection. J Immunol. 2011;186:1011-21 pubmed publisher
Coleman C, Nealy M, Tibbetts S. Immature and transitional B cells are latency reservoirs for a gammaherpesvirus. J Virol. 2010;84:13045-52 pubmed publisher
Ota M, Duong B, Torkamani A, Doyle C, Gavin A, Ota T, et al. Regulation of the B cell receptor repertoire and self-reactivity by BAFF. J Immunol. 2010;185:4128-36 pubmed publisher
Duong B, Ota T, Ait Azzouzene D, Aoki Ota M, VELA J, Huber C, et al. Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. J Immunol. 2010;184:4143-58 pubmed publisher
Pereira J, Xu Y, Cyster J. A role for S1P and S1P1 in immature-B cell egress from mouse bone marrow. PLoS ONE. 2010;5:e9277 pubmed publisher
Gibb D, El Shikh M, Kang D, Rowe W, El Sayed R, Cichy J, et al. ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J Exp Med. 2010;207:623-35 pubmed publisher
Sanchez Aguilera A, Rattmann I, Drew D, Müller L, Summey V, Lucas D, et al. Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia. 2010;24:97-104 pubmed publisher
Foote J, Kearney J. Generation of B cell memory to the bacterial polysaccharide alpha-1,3 dextran. J Immunol. 2009;183:6359-68 pubmed publisher
Chen X, Welner R, Kincade P. A possible contribution of retinoids to regulation of fetal B lymphopoiesis. Eur J Immunol. 2009;39:2515-24 pubmed publisher
Guay H, Mishra R, Garcea R, Welsh R, Szomolanyi Tsuda E. Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells. J Immunol. 2009;183:518-23 pubmed publisher
Yunk L, Meng W, Cohen P, Eisenberg R, Luning Prak E. Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement. J Immunol. 2009;183:452-61 pubmed publisher
Khiem D, Cyster J, Schwarz J, Black B. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A. 2008;105:17067-72 pubmed publisher
Yang Q, Kardava L, St Leger A, Martincic K, Varnum Finney B, Bernstein I, et al. E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J Immunol. 2008;181:5885-94 pubmed
Wilker P, Kohyama M, Sandau M, Albring J, Nakagawa O, Schwarz J, et al. Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol. 2008;9:603-12 pubmed publisher
Antony P, HOEK K, Sarmah B, Khan W. Micro-scale flow cytometry-based and biochemical analysis of lipid signaling in primary B cell subpopulations. Biol Proced Online. 2007;9:73-83 pubmed publisher
Kikuchi K, Kondo M. Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth. Proc Natl Acad Sci U S A. 2006;103:17852-7 pubmed
Lesley R, Kelly L, Xu Y, Cyster J. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc Natl Acad Sci U S A. 2006;103:10717-22 pubmed
Dean Y, McGreal E, Akatsu H, Gasque P. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. J Biol Chem. 2000;275:34382-92 pubmed
McKearn J, Baum C, Davie J. Cell surface antigens expressed by subsets of pre-B cells and B cells. J Immunol. 1984;132:332-9 pubmed
product information
Product Type :
Antibody
Product Name :
CD93 (AA4.1) Monoclonal Antibody (AA4.1), APC, eBioscience™
Catalog # :
17-5892-81
Quantity :
50µg
Price (USD) :
167.00 USD
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.125 µg/test
Species :
Mouse
Clone :
AA4.1
Isotype :
IgG2b, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.125 µg/test
Aliases :
6030404G09Rik; AA145088; Aa4; AA4.1; AW555904; C1q receptor; C1q receptor 1; C1q/MBL/SPA receptor; C1qR; C1qR(p); C1QR1; C1qrp; Cd93; CD93 antigen; CD93 molecule; CDw93; Cell surface antigen AA4; complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Ly-68; Lymphocyte antigen 68; matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA