Ly-49H Monoclonal Antibody (3D10), APC, eBioscience™ | Invitrogen 17-5886-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ly-49H Monoclonal Antibody (3D10), APC, eBioscience™

catalog :

17-5886-82

quantity :

100µg

price :

239.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

3D10

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 17

Reference
Yang M, Chen S, Du J, He J, Wang Y, Li Z, et al. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nat Commun. 2016;7:12730 pubmed publisher
Yang E, Singh B, Paustian A, Kambayashi T. Diacylglycerol Kinase ? Is a Target To Enhance NK Cell Function. J Immunol. 2016;197:934-41 pubmed publisher
Sullivan R, Fogel L, Leong J, Schneider S, Wong R, Romee R, et al. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013;191:5904-13 pubmed publisher
Fogel L, Sun M, Geurs T, Carayannopoulos L, French A. Markers of nonselective and specific NK cell activation. J Immunol. 2013;190:6269-76 pubmed publisher
Merino E, Abeyweera T, Firth M, Zawislak C, Basu R, Liu X, et al. Protein kinase C-? clustering at immunological synapses amplifies effector responses in NK cells. J Immunol. 2012;189:4859-69 pubmed publisher
Lee G, Liou Y, Wang S, Ko K, Jiang S, Liao N. Different NK cell developmental events require different levels of IL-15 trans-presentation. J Immunol. 2011;187:1212-21 pubmed publisher
Busche A, Schmitz S, Fleige H, Robbins S, Walzer T, Stewart C, et al. Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection. J Immunol. 2011;186:2918-25 pubmed publisher
Eckelhart E, Warsch W, Zebedin E, Simma O, Stoiber D, Kolbe T, et al. A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development. Blood. 2011;117:1565-73 pubmed publisher
Beilke J, Benjamin J, Lanier L. The requirement for NKG2D in NK cell-mediated rejection of parental bone marrow grafts is determined by MHC class I expressed by the graft recipient. Blood. 2010;116:5208-16 pubmed publisher
Eidenschenk C, Crozat K, Krebs P, Arens R, Popkin D, Arnold C, et al. Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells. Proc Natl Acad Sci U S A. 2010;107:9759-64 pubmed publisher
Fodil Cornu N, Pyzik M, Vidal S. Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus. Methods Mol Biol. 2010;612:393-409 pubmed publisher
Orr M, Sun J, Hesslein D, Arase H, Phillips J, Takai T, et al. Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection. J Exp Med. 2009;206:807-17 pubmed publisher
Chen S, Kawashima H, Lowe J, Lanier L, Fukuda M. Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. J Exp Med. 2005;202:1679-89 pubmed
Caraux A, Kim N, Bell S, Zompi S, Ranson T, Lesjean Pottier S, et al. Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood. 2006;107:994-1002 pubmed
Tassi I, Presti R, Kim S, Yokoyama W, Gilfillan S, Colonna M. Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol. 2005;175:749-54 pubmed
Brown M, Dokun A, Heusel J, Smith H, Beckman D, Blattenberger E, et al. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 2001;292:934-7 pubmed
Smith H, Chuang H, Wang L, Salcedo M, Heusel J, Yokoyama W. Nonstochastic coexpression of activation receptors on murine natural killer cells. J Exp Med. 2000;191:1341-54 pubmed

product information

Product Type :

Antibody

Product Name :

Ly-49H Monoclonal Antibody (3D10), APC, eBioscience™

Catalog # :

17-5886-82

Quantity :

100µg

Price (USD) :

239.00 USD

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 µg/test

Species :

Mouse

Clone :

3D10

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Ly49H is a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly49H, like Ly49D, lacks the characteristic ITAM (immunoreceptor tyrosine-based inhibitory motif) and contains an arginine in the transmembrane domain implying these molecules act as activation receptors. Ly49H is expressed in a subset of NK cells but not NKT (NK1.1/CD3+) cells. Natural killer cells can express several Ly49 proteins.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 µg/test

Aliases :

Cmv1; Cmv-1; cytomegalovirus resistance 1; killer cell lectin-like receptor 8; killer cell lectin-like receptor, subfamily A, member 8; Klra8; Ly49H; Ly-49h; Ly49-h; Ly49u ; Lymphocyte antigen 49h; T-cell surface glycoprotein Ly-49H

more info or order :

Invitrogen product webpage