This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), APC, eBioscience
catalog :
17-5874-81
quantity :
50 ug
price :
US 267.00
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
DTA-1

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 80
Reference
Xu L, Huang Q, Wang H, Hao Y, Bai Q, Hu J, et al. The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells. Immunity. 2017;47:538-551.e5 pubmed publisher
Ali N, Zirak B, Rodriguez R, Pauli M, Truong H, Lai K, et al. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017;169:1119-1129.e11 pubmed publisher
Dey M, Chang A, Wainwright D, Ahmed A, Han Y, Balyasnikova I, et al. Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model. J Neuroimmunol. 2014;266:33-42 pubmed publisher
Schmitt E, Haribhai D, Jeschke J, Co D, Ziegelbauer J, Yan K, et al. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol. 2013;191:5460-76 pubmed publisher
Lee J, Jeon E, Kim N, Nam Y, Im K, Lim J, et al. The synergistic immunoregulatory effects of culture-expanded mesenchymal stromal cells and CD4(+)25(+)Foxp3+ regulatory T cells on skin allograft rejection. PLoS ONE. 2013;8:e70968 pubmed publisher
Huang H, Dawicki W, Lu M, Nayyar A, Zhang X, Gordon J. Regulatory dendritic cell expression of MHCII and IL-10 are jointly requisite for induction of tolerance in a murine model of OVA-asthma. Allergy. 2013;68:1126-35 pubmed publisher
Jhunjhunwala S, Chen L, Nichols E, Thomson A, Raimondi G, Little S. All-trans retinoic acid and rapamycin synergize with transforming growth factor-?1 to induce regulatory T cells but confer different migratory capacities. J Leukoc Biol. 2013;94:981-9 pubmed publisher
Karlsson F, Martinez N, Gray L, Zhang S, Tsunoda I, Grisham M. Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation. Inflamm Bowel Dis. 2013;19:2282-94 pubmed publisher
Hu Z, Zhang W, Usherwood E. Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect. J Immunol. 2013;191:312-22 pubmed publisher
Ehrentraut H, Clambey E, McNamee E, Brodsky K, Ehrentraut S, Poth J, et al. CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J. 2013;27:2207-19 pubmed publisher
Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, et al. Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity. J Invest Dermatol. 2013;133:702-711 pubmed publisher
Schmitt E, Haribhai D, Williams J, Aggarwal P, Jia S, Charbonnier L, et al. IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. J Immunol. 2012;189:5638-48 pubmed publisher
Krishnamoorthy N, Khare A, Oriss T, Raundhal M, Morse C, Yarlagadda M, et al. Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma. Nat Med. 2012;18:1525-30 pubmed publisher
Baru A, Untucht C, Ganesh V, Hesse C, Mayer C, Sparwasser T. Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice. PLoS ONE. 2012;7:e44760 pubmed publisher
Cuss S, Green E. Abrogation of CD40-CD154 signaling impedes the homeostasis of thymic resident regulatory T cells by altering the levels of IL-2, but does not affect regulatory T cell development. J Immunol. 2012;189:1717-25 pubmed publisher
Carrier Y, Whitters M, Miyashiro J, LaBranche T, Ramon H, Benoit S, et al. Enhanced GITR/GITRL interactions augment IL-27 expression and induce IL-10-producing Tr-1 like cells. Eur J Immunol. 2012;42:1393-404 pubmed publisher
Diao J, Mikhailova A, Tang M, Gu H, Zhao J, Cattral M. Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells. Blood. 2012;119:4919-27 pubmed publisher
Sule G, Suzuki M, Guse K, Cela R, Rodgers J, Lee B. Cytokine-conditioned dendritic cells induce humoral tolerance to protein therapy in mice. Hum Gene Ther. 2012;23:769-80 pubmed publisher
Teodorovic L, Riccardi C, Torres R, Pelanda R. Murine B cell development and antibody responses to model antigens are not impaired in the absence of the TNF receptor GITR. PLoS ONE. 2012;7:e31632 pubmed publisher
Karwot R, Ubel C, Bopp T, Schmitt E, Finotto S. Increased immunosuppressive function of CD4(+)CD25(+)Foxp3(+)GITR+ T regulatory cells from NFATc2((-/-)) mice controls allergen-induced experimental asthma. Immunobiology. 2012;217:905-11 pubmed publisher
Ganeshan K, Bryce P. Regulatory T cells enhance mast cell production of IL-6 via surface-bound TGF-?. J Immunol. 2012;188:594-603 pubmed publisher
Grigoriadis G, Vasanthakumar A, Banerjee A, Grumont R, Overall S, Gleeson P, et al. c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells. PLoS ONE. 2011;6:e26851 pubmed publisher
Takata M, Nakagomi T, Kashiwamura S, Nakano Doi A, Saino O, Nakagomi N, et al. Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke. Cell Death Differ. 2012;19:756-67 pubmed publisher
Wollenberg I, Agua Doce A, Hernandez A, Almeida C, Oliveira V, Faro J, et al. Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells. J Immunol. 2011;187:4553-60 pubmed publisher
Wainwright D, Sengupta S, Han Y, Lesniak M. Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors. Neuro Oncol. 2011;13:1308-23 pubmed publisher
Zietara N, Łyszkiewicz M, Krueger A, Weiss S. ICOS-dependent stimulation of NKT cells by marginal zone B cells. Eur J Immunol. 2011;41:3125-34 pubmed publisher
Van Der Werf N, Redpath S, Phythian Adams A, Azuma M, Allen J, Maizels R, et al. Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo. J Immunol. 2011;187:1411-20 pubmed publisher
Alexander C, Tygrett L, Boyden A, Wolniak K, Legge K, Waldschmidt T. T regulatory cells participate in the control of germinal centre reactions. Immunology. 2011;133:452-68 pubmed publisher
Yokoyama T, Matsuda S, Takae Y, Wada N, Nishikawa T, Amagai M, et al. Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris. Int Immunol. 2011;23:365-73 pubmed publisher
Jing W, Yan X, Hallett W, Gershan J, Johnson B. Depletion of CD25? T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma. Blood. 2011;117:6952-62 pubmed publisher
Francis R, Feng G, Tha In T, Lyons I, Wood K, Bushell A. Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells. Eur J Immunol. 2011;41:726-38 pubmed publisher
Gültner S, Kuhlmann T, Hesse A, Weber J, Riemer C, Baier M, et al. Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE. Eur J Immunol. 2010;40:3403-12 pubmed publisher
Lee H, Lee H, Kwon Y, Lee J, Kim J, Shin M, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. J Immunol. 2010;185:6698-705 pubmed publisher
He C, Prevot N, Boitard C, Avner P, Rogner U. Inhibition of type 1 diabetes by upregulation of the circadian rhythm-related aryl hydrocarbon receptor nuclear translocator-like 2. Immunogenetics. 2010;62:585-92 pubmed publisher
Wang G, Khattar M, Guo Z, Miyahara Y, Linkes S, Sun Z, et al. IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation. Immunol Lett. 2010;132:61-8 pubmed publisher
Teng L, Liu L, Su Y, Yuan X, Li J, Fu Q, et al. Suppression of alloimmunity in mice by regulatory T cells converted with conditioned media. J Surg Res. 2011;171:797-806 pubmed publisher
Chen X, Hamano R, Subleski J, Hurwitz A, Howard O, Oppenheim J. Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells. J Immunol. 2010;185:174-82 pubmed publisher
Zhang H, Podojil J, Chang J, Luo X, Miller S. TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis. J Immunol. 2010;184:6629-36 pubmed publisher
Rolla S, Ria F, Occhipinti S, Di Sante G, Iezzi M, Spadaro M, et al. Erbb2 DNA vaccine combined with regulatory T cell deletion enhances antibody response and reveals latent low-avidity T cells: potential and limits of its therapeutic efficacy. J Immunol. 2010;184:6124-32 pubmed publisher
Vang K, Yang J, Pagán A, Li L, Wang J, Green J, et al. Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development. J Immunol. 2010;184:4074-7 pubmed publisher
Nasta F, Laudisi F, Sambucci M, Rosado M, Pioli C. Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency. J Immunol. 2010;184:3470-7 pubmed publisher
Cavassani K, Carson W, Moreira A, Wen H, Schaller M, Ishii M, et al. The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth. Blood. 2010;115:4403-11 pubmed publisher
Sonawane S, Kim J, Lee M, Lee S, Duff P, Moore D, et al. GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation. 2009;88:1169-77 pubmed publisher
Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt U. Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation. J Immunol. 2009;183:6124-34 pubmed publisher
Blache C, Adriouch S, Calbo S, Drouot L, Dulauroy S, Arnoult C, et al. Cutting edge: CD4-independent development of functional FoxP3+ regulatory T cells. J Immunol. 2009;183:4182-6 pubmed publisher
Chen G, Han G, Feng J, Wang J, Wang R, Xu R, et al. Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells. PLoS ONE. 2009;4:e7034 pubmed publisher
van Olffen R, Koning N, van Gisbergen K, Wensveen F, Hoek R, Boon L, et al. GITR triggering induces expansion of both effector and regulatory CD4+ T cells in vivo. J Immunol. 2009;182:7490-500 pubmed publisher
McGee H, Agrawal D. Naturally occurring and inducible T-regulatory cells modulating immune response in allergic asthma. Am J Respir Crit Care Med. 2009;180:211-25 pubmed publisher
Imai N, Ikeda H, Tawara I, Wang L, Wang L, Nishikawa H, et al. Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression. Cancer Sci. 2009;100:1317-25 pubmed publisher
Kagami S, Owada T, Kanari H, Saito Y, Suto A, Ikeda K, et al. Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells. Int Immunol. 2009;21:679-89 pubmed publisher
Nagahama K, Fehervari Z, Oida T, Yamaguchi T, Ogawa O, Sakaguchi S. Differential control of allo-antigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance. Int Immunol. 2009;21:379-91 pubmed publisher
Imai N, Ikeda H, Tawara I, Shiku H. Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells. Eur J Immunol. 2009;39:241-53 pubmed publisher
DiPaolo R, Shevach E. CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg. Eur J Immunol. 2009;39:234-40 pubmed publisher
Schartner J, Singh A, Dahlberg P, Nettenstrom L, Seroogy C. Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures. Clin Exp Immunol. 2009;155:348-56 pubmed publisher
Saito K, Torii M, Ma N, Tsuchiya T, Wang L, Hori T, et al. Differential regulatory function of resting and preactivated allergen-specific CD4+ CD25+ regulatory T cells in Th2-type airway inflammation. J Immunol. 2008;181:6889-97 pubmed
Liston A, Lu L, O Carroll D, Tarakhovsky A, Rudensky A. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med. 2008;205:1993-2004 pubmed publisher
Laronne Bar On A, Zipori D, Haran Ghera N. Increased regulatory versus effector T cell development is associated with thymus atrophy in mouse models of multiple myeloma. J Immunol. 2008;181:3714-24 pubmed
Inaba H, Steeves M, Nguyen P, Geiger T. In vivo suppression of naive CD4 T cell responses by IL-2- and antigen-stimulated T lymphocytes in the absence of APC competition. J Immunol. 2008;181:3323-35 pubmed
Marshall N, Vorachek W, Steppan L, Mourich D, Kerkvliet N. Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Immunol. 2008;181:2382-91 pubmed
Chen S, Ndhlovu L, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, et al. Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells. Eur J Immunol. 2008;38:2229-40 pubmed publisher
Peng B, Ye P, Blazar B, Freeman G, Rawlings D, Ochs H, et al. Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice. Blood. 2008;112:1662-72 pubmed publisher
Joetham A, Matsubara S, Okamoto M, Takeda K, Miyahara N, Dakhama A, et al. Plasticity of regulatory T cells: subversion of suppressive function and conversion to enhancement of lung allergic responses. J Immunol. 2008;180:7117-24 pubmed
Chen X, Subleski J, Kopf H, Howard O, Männel D, Oppenheim J. Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells. J Immunol. 2008;180:6467-71 pubmed
Lutsiak M, Tagaya Y, Adams A, Schlom J, Sabzevari H. Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells. J Immunol. 2008;180:5871-81 pubmed
Vanoosten R, Griffith T. Activation of tumor-specific CD8+ T Cells after intratumoral Ad5-TRAIL/CpG oligodeoxynucleotide combination therapy. Cancer Res. 2007;67:11980-90 pubmed
Taylor M, Harris A, Babayan S, Bain O, Culshaw A, Allen J, et al. CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo. J Immunol. 2007;179:4626-34 pubmed
Scumpia P, Delano M, Kelly Scumpia K, Weinstein J, Wynn J, Winfield R, et al. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood. 2007;110:3673-81 pubmed
Kapp J, Honjo K, Kapp L, Goldsmith K, Bucy R. Antigen, in the presence of TGF-beta, induces up-regulation of FoxP3gfp+ in CD4+ TCR transgenic T cells that mediate linked suppression of CD8+ T cell responses. J Immunol. 2007;179:2105-14 pubmed
Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, et al. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007;178:4937-46 pubmed
González J, Tamayo E, Santiuste I, Marquina R, Buelta L, Gonzalez Gay M, et al. CD4+CD25+ T cell-dependent inhibition of autoimmunity in transgenic mice overexpressing human Bcl-2 in T lymphocytes. J Immunol. 2007;178:2778-86 pubmed
Hubeau C, Apostolou I, Kobzik L. Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice. J Immunol. 2007;178:1477-87 pubmed
Burchill M, Yang J, Vogtenhuber C, Blazar B, Farrar M. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol. 2007;178:280-90 pubmed
Kapp J, Honjo K, Kapp L, Xu X, Cozier A, Bucy R. TCR transgenic CD8+ T cells activated in the presence of TGFbeta express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol. 2006;18:1549-62 pubmed
Ambrosino E, Spadaro M, Iezzi M, Curcio C, Forni G, Musiani P, et al. Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance. Cancer Res. 2006;66:7734-40 pubmed
Ono M, Shimizu J, Miyachi Y, Sakaguchi S. Control of autoimmune myocarditis and multiorgan inflammation by glucocorticoid-induced TNF receptor family-related protein(high), Foxp3-expressing CD25+ and CD25- regulatory T cells. J Immunol. 2006;176:4748-56 pubmed
Sutmuller R, den Brok M, Kramer M, Bennink E, Toonen L, Kullberg B, et al. Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest. 2006;116:485-94 pubmed
Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, et al. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med. 2005;202:885-91 pubmed
Kataoka H, Takahashi S, Takase K, Yamasaki S, Yokosuka T, Koike T, et al. CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4. Int Immunol. 2005;17:421-7 pubmed
Thorstenson K, Herzovi L, Khoruts A. A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25+CD4 T cells in vivo. Int Immunol. 2005;17:335-42 pubmed
Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol. 2002;3:135-42 pubmed
product information
Product Type :
Antibody
Product Name :
CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), APC, eBioscience
Catalog # :
17-5874-81
Quantity :
50 ug
Price :
US 267.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.06 ug/test
Species :
Mouse
Clone :
DTA-1
Isotype :
IgG2b, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.06 ug/test
Aliases :
Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA