T-bet Monoclonal Antibody (eBio4B10 (4B10)), APC, eBioscience | Invitrogen 17-5825-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

T-bet Monoclonal Antibody (eBio4B10 (4B10)), APC, eBioscience

catalog :

17-5825-80

quantity :

25 ug

price :

US 223.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

eBio4B10 (4B10)

reactivity :

human, mouse, rhesus macaque

application :

flow cytometry

citations: 25

Reference
Guo H, Li X, Mao D, Wang H, Wei L, Qu D, et al. Homologous-magnetic dual-targeted metal-organic framework to improve the Anti-hepatocellular carcinoma efficacy of PD-1 inhibitor. J Nanobiotechnology. 2024;22:206 pubmed publisher
Wang L, Zhang X, Zhang H, Lu K, Li M, Li X, et al. Excessive apoptosis of Rip1-deficient T cells leads to premature aging. EMBO Rep. 2023;24:e57925 pubmed publisher
Ro x17e mani x107 C, Lisni x107 B, Pribani x107 Mate x161 i x107 M, Mihali x107 A, Hir x161 l L, Park E, et al. Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells. Nat Commun. 2023;14:6412 pubmed publisher
Chan L, Mehrani Y, Minott J, Bridle B, Karimi K. The Potential of Dendritic-Cell-Based Vaccines to Modulate Type 3 Innate Lymphoid Cell Populations. Int J Mol Sci. 2023;24: pubmed publisher
Viladomiu M, Khounlotham M, Dogan B, Lima S, Elsaadi A, Cardakli E, et al. Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis. Cell Rep. 2022;41:111637 pubmed publisher
Korniotis S, Saichi M, Trichot C, Hoffmann C, Amblard E, Viguier A, et al. GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner. J Cell Sci. 2022;135: pubmed publisher
Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, et al. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022;55:65-81.e9 pubmed publisher
Kalim K, Yang J, Modur V, Nguyen P, Li Y, Zheng Y, et al. Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity. Front Immunol. 2021;12:726393 pubmed publisher
Zhao Z, Wang H, Shi M, Zhu T, Pediongco T, Lim X, et al. Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection. Nat Commun. 2021;12:4355 pubmed publisher
Sia W, Hey Y, Foo R, Wang L, Leeansyah E. Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells. STAR Protoc. 2021;2:100487 pubmed publisher
Li W, Luo Y, Xu H, Ma Q, Yao Q. Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice. J Int Med Res. 2021;49:300060521998471 pubmed publisher
Bonilla W, Kirchhammer N, Marx A, Kallert S, Krzyzaniak M, Lu M, et al. Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack. Cell Rep Med. 2021;2:100209 pubmed publisher
Budhu S, Giese R, Gupta A, Fitzgerald K, Zappasodi R, Schad S, et al. Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma. Cell Rep. 2021;34:108620 pubmed publisher
Zu J, Yao L, Song Y, Cui Y, Guan M, Chen R, et al. Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa. Front Immunol. 2020;11:570888 pubmed publisher
Soon M, Lee H, Engel J, Straube J, Thomas B, Pernold C, et al. Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory. Nat Immunol. 2020;21:1597-1610 pubmed publisher
Marinaik C, Kingstad Bakke B, Lee W, Hatta M, Sonsalla M, Larsen A, et al. Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants. Cell Rep Med. 2020;1:100095 pubmed publisher
Tao L, Farooq M, Gao Y, Zhang L, Niu C, Ajmal I, et al. CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells. Cancers (Basel). 2020;12: pubmed publisher
Si Y, Tian Q, Zhao F, Kelly S, Shores L, Camacho D, et al. Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses. Sci Adv. 2020;6:eaba0995 pubmed publisher
Wang Z, Ji N, Chen Z, Sun Z, Wu C, Yu W, et al. MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation. Allergy Asthma Immunol Res. 2020;12:859-876 pubmed publisher
Liu Y, Bockermann R, Hadi M, Safari I, Carrion B, Kveiborg M, et al. ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation. Cell Mol Immunol. 2020;: pubmed publisher
DiToro D, Harbour S, Bando J, Benavides G, Witte S, Laufer V, et al. Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity. Immunity. 2020;52:650-667.e10 pubmed publisher
Magen A, Nie J, Ciucci T, Tamoutounour S, Zhao Y, Mehta M, et al. Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells. Cell Rep. 2019;29:3019-3032.e6 pubmed publisher
Liu C, Whitener R, Lin A, Xu Y, Chen J, Savinov A, et al. Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes. Front Immunol. 2019;10:952 pubmed publisher
Kim C, Baccarella A, Bayat A, Pepper M, Fontana M. FCRL5+ Memory B Cells Exhibit Robust Recall Responses. Cell Rep. 2019;27:1446-1460.e4 pubmed publisher
Stradner M, Cheung K, Lasorella A, Goldrath A, D Cruz L. Id2 regulates hyporesponsive invariant natural killer T cells. Immunol Cell Biol. 2016;94:640-5 pubmed publisher

product information

Product Type :

Antibody

Product Name :

T-bet Monoclonal Antibody (eBio4B10 (4B10)), APC, eBioscience

Catalog # :

17-5825-80

Quantity :

25 ug

Price :

US 223.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rhesus Monkey

Applications :

Flow Cytometry: 0.25 ug/test

Species :

Human, Mouse, Rhesus Monkey

Clone :

eBio4B10 (4B10)

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 ug/test

Aliases :

HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21