TCR V alpha 2 Monoclonal Antibody (B20.1), APC, eBioscience | Invitrogen 17-5812-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 2 Monoclonal Antibody (B20.1), APC, eBioscience

catalog :

17-5812-82

quantity :

100 ug

price :

US 379.00

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

B20.1

reactivity :

mouse

application :

flow cytometry

citations: 17

Reference
Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher
Flosbach M, Oberle S, Scherer S, Zecha J, von Hoesslin M, Wiede F, et al. PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. Cell Rep. 2020;32:107957 pubmed publisher
Sidwell T, Liao Y, Garnham A, Vasanthakumar A, Gloury R, Blume J, et al. Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis. Nat Commun. 2020;11:252 pubmed publisher
Preite S, Cannons J, Radtke A, Vujkovic Cvijin I, Gomez Rodriguez J, Volpi S, et al. Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity. Nat Immunol. 2018;19:986-1000 pubmed publisher
Prendergast K, Daniels N, Petersen T, Hermans I, Kirman J. Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection. Front Immunol. 2018;9:953 pubmed publisher
Lamothe R, Kolte P, Vo T, Ferrari J, Gelsinger T, Wong J, et al. Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:281 pubmed publisher
Purroy C, Fairchild R, Tanaka T, Baldwin W, Manrique J, Madsen J, et al. Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival. J Am Soc Nephrol. 2017;28:2377-2392 pubmed publisher
Aguet F, Upadhyayula S, Gaudin R, Chou Y, Cocucci E, He K, et al. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 2016;27:3418-3435 pubmed
Xu Y, Liu Y, Yang C, Kang L, Wang M, Hu J, et al. Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses. Immunology. 2016;149:157-71 pubmed publisher
Jenkinson W, Nakamura K, White A, Jenkinson E, Anderson G. Normal T cell selection occurs in CD205-deficient thymic microenvironments. PLoS ONE. 2012;7:e53416 pubmed publisher
Jaensson Gyllenbäck E, Kotarsky K, Zapata F, Persson E, Gundersen T, Blomhoff R, et al. Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells. Mucosal Immunol. 2011;4:438-47 pubmed publisher
Graham D, Akilesh H, Gmyrek G, Piccio L, Gilfillan S, Sim J, et al. ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood. 2010;116:3208-18 pubmed publisher
Elftman M, Hunzeker J, Mellinger J, Bonneau R, Norbury C, Truckenmiller M. Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function. J Immunol. 2010;184:1867-75 pubmed publisher
Bedoret D, Wallemacq H, Marichal T, Desmet C, Quesada Calvo F, Henry E, et al. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest. 2009;119:3723-38 pubmed publisher
Seedhom M, Jellison E, Daniels K, Welsh R. High frequencies of virus-specific CD8+ T-cell precursors. J Virol. 2009;83:12907-16 pubmed publisher
Gregoire C, Rebai N, Schweisguth F, Necker A, Mazza G, Auphan N, et al. Engineered secreted T-cell receptor alpha beta heterodimers. Proc Natl Acad Sci U S A. 1991;88:8077-81 pubmed
Pircher H, Rebai N, Groettrup M, Gregoire C, Speiser D, Happ M, et al. Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody. Eur J Immunol. 1992;22:399-404 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 2 Monoclonal Antibody (B20.1), APC, eBioscience

Catalog # :

17-5812-82

Quantity :

100 ug

Price :

US 379.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

B20.1

Isotype :

IgG2a, lambda

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

TCRVA; TCRVA2; V alpha 2; V alpha-2 TCR; Va 2; Va2; Valpha 2; Valpha2