TCR V alpha 2 Monoclonal Antibody (B20.1), APC, eBioscience™ | Invitrogen 17-5812-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 2 Monoclonal Antibody (B20.1), APC, eBioscience™

catalog :

17-5812-80

quantity :

25µg

price :

110.00 USD

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

B20.1

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:100; loading ...; fig 3c	Stebegg M, Bignon A, Hill D, Silva Cayetano A, Krueger C, Vanderleyden I, et al. Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination. elife. 2020;9: pubmed publisher
	Prendergast K, Daniels N, Petersen T, Hermans I, Kirman J. Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection. Front Immunol. 2018;9:953 pubmed publisher
	Xu Y, Liu Y, Yang C, Kang L, Wang M, Hu J, et al. Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses. Immunology. 2016;149:157-71 pubmed publisher
	Jenkinson W, Nakamura K, White A, Jenkinson E, Anderson G. Normal T cell selection occurs in CD205-deficient thymic microenvironments. PLoS ONE. 2012;7:e53416 pubmed publisher
	Jaensson Gyllenbäck E, Kotarsky K, Zapata F, Persson E, Gundersen T, Blomhoff R, et al. Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells. Mucosal Immunol. 2011;4:438-47 pubmed publisher
	Graham D, Akilesh H, Gmyrek G, Piccio L, Gilfillan S, Sim J, et al. ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood. 2010;116:3208-18 pubmed publisher
	Elftman M, Hunzeker J, Mellinger J, Bonneau R, Norbury C, Truckenmiller M. Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function. J Immunol. 2010;184:1867-75 pubmed publisher
	Bedoret D, Wallemacq H, Marichal T, Desmet C, Quesada Calvo F, Henry E, et al. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest. 2009;119:3723-38 pubmed publisher
	Seedhom M, Jellison E, Daniels K, Welsh R. High frequencies of virus-specific CD8+ T-cell precursors. J Virol. 2009;83:12907-16 pubmed publisher
	Gregoire C, Rebai N, Schweisguth F, Necker A, Mazza G, Auphan N, et al. Engineered secreted T-cell receptor alpha beta heterodimers. Proc Natl Acad Sci U S A. 1991;88:8077-81 pubmed
	Pircher H, Rebai N, Groettrup M, Gregoire C, Speiser D, Happ M, et al. Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody. Eur J Immunol. 1992;22:399-404 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 2 Monoclonal Antibody (B20.1), APC, eBioscience™

Catalog # :

17-5812-80

Quantity :

25µg

Price (USD) :

110.00 USD

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

B20.1

Isotype :

IgG2a, lambda

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

TCRVA; TCRVA2; V alpha 2; V alpha-2 TCR; Va 2; Va2; Valpha 2; Valpha2

more info or order :

Invitrogen product webpage