TCR V alpha 24 J alpha 18 Monoclonal Antibody (6B11), APC, eBioscience | Invitrogen 17-5806-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 24 J alpha 18 Monoclonal Antibody (6B11), APC, eBioscience

catalog :

17-5806-42

quantity :

100 Tests

price :

US 365.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

6B11

reactivity :

human

application :

flow cytometry

citations: 13

Reference
Pean P, Nouhin J, Ratana M, Madec Y, Borand L, Marcy O, et al. High Activation of γδ T Cells and the γδ2pos T-Cell Subset Is Associated With the Onset of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, ANRS 12153 CAPRI NK. Front Immunol. 2019;10:2018 pubmed publisher
Lin G, Field J, Yu J, Ken R, Neuberg D, Nathan D, et al. NF-?B is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors. PLoS ONE. 2013;8:e74664 pubmed publisher
Venken K, Decruy T, Aspeslagh S, Van Calenbergh S, Lambrecht B, Elewaut D. Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells. J Immunol. 2013;191:2174-83 pubmed publisher
Zeng S, Ghnewa Y, O Reilly V, Lyons V, Atzberger A, Hogan A, et al. Human invariant NKT cell subsets differentially promote differentiation, antibody production, and T cell stimulation by B cells in vitro. J Immunol. 2013;191:1666-76 pubmed publisher
Hofmann S, Bosma A, Bruckner Tuderman L, Vukmanovic Stejic M, Jury E, Isenberg D, et al. Invariant natural killer T cells are enriched at the site of cutaneous inflammation in lupus erythematosus. J Dermatol Sci. 2013;71:22-8 pubmed publisher
Tang X, Jo J, Tan A, Sandalova E, Chia A, Tan K, et al. IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol. 2013;190:3142-52 pubmed publisher
Field J, Lin G, Okam M, Majerus E, Keefer J, Onyekwere O, et al. Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson. Blood. 2013;121:3329-34 pubmed publisher
O Reilly V, Zeng S, Bricard G, Atzberger A, Hogan A, Jackson J, et al. Distinct and overlapping effector functions of expanded human CD4+, CD8?+ and CD4-CD8?- invariant natural killer T cells. PLoS ONE. 2011;6:e28648 pubmed publisher
Kim H, Eyheramonho M, Pichavant M, Gonzalez Cambaceres C, Matangkasombut P, Cervio G, et al. A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans. J Clin Invest. 2011;121:1111-8 pubmed publisher
Liu L, Lu J, Chao P, Lin L, Zhang Z, Yang T. Lower prevalence of circulating invariant natural killer T (iNKT) cells in patients with acute myocardial infarction undergoing primary coronary stenting. Int Immunopharmacol. 2011;11:480-4 pubmed publisher
Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, et al. Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders. Blood. 2009;114:3208-15 pubmed publisher
Montoya C, Pollard D, Martinson J, Kumari K, Wasserfall C, Mulder C, et al. Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11. Immunology. 2007;122:1-14 pubmed
Thomas S, Hou R, Boyson J, Means T, Hess C, Olson D, et al. CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol. 2003;171:2571-80 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 24 J alpha 18 Monoclonal Antibody (6B11), APC, eBioscience

Catalog # :

17-5806-42

Quantity :

100 Tests

Price :

US 365.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.5 ug)/test

Species :

Human

Clone :

6B11

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.5 ug)/test

Aliases :

Va24; Valpha24