TCR V alpha 11 Monoclonal Antibody (RR8-1), APC, eBioscience | Invitrogen 17-5800-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 11 Monoclonal Antibody (RR8-1), APC, eBioscience

catalog :

17-5800-82

quantity :

100 ug

price :

US 339.00

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

RR8-1

reactivity :

mouse

application :

flow cytometry

citations: 8

Reference
Lee M, Tuohy P, Kim C, Lichauco K, Parrish H, Van Doorslaer K, et al. Enhancing and inhibitory motifs regulate CD4 activity. elife. 2022;11: pubmed publisher
Krishnamurthy B, Chee J, Jhala G, Fynch S, Graham K, Santamaria P, et al. Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells. Diabetes. 2012;61:425-35 pubmed publisher
Rausch M, Irvine K, Antony P, Restifo N, Cresswell P, Hastings K. GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1. J Immunol. 2010;185:2828-35 pubmed publisher
Morris G, Allen P. Cutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease. J Immunol. 2009;182:6639-43 pubmed publisher
Tsang J, Tanriver Y, Jiang S, Xue S, Ratnasothy K, Chen D, et al. Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. J Clin Invest. 2008;118:3619-28 pubmed publisher
Aifantis I, Bassing C, Garbe A, Sawai K, Alt F, von Boehmer H. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med. 2006;203:1543-50 pubmed
Terrence K, Pavlovich C, Matechak E, Fowlkes B. Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells. J Exp Med. 2000;192:537-48 pubmed
Jameson S, Nakajima P, Brooks J, Heath W, Kanagawa O, Gascoigne N. The T cell receptor V alpha 11 gene family. Analysis of allelic sequence polymorphism and demonstration of J alpha region-dependent recognition by allele-specific antibodies. J Immunol. 1991;147:3185-93 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 11 Monoclonal Antibody (RR8-1), APC, eBioscience

Catalog # :

17-5800-82

Quantity :

100 ug

Price :

US 339.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 ug/test

Species :

Mouse

Clone :

RR8-1

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/test

Aliases :

TCR V alpha11; TCRV alpha 11; TCRV alpha11; Va11; Valpha11