TCR V alpha 3.2 Monoclonal Antibody (RR3-16), APC, eBioscience | Invitrogen 17-5799-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 3.2 Monoclonal Antibody (RR3-16), APC, eBioscience

catalog :

17-5799-82

quantity :

100 ug

price :

US 354.00

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

RR3-16

reactivity :

mouse

application :

flow cytometry

citations: 9

Reference
Prasad M, Wojciech L, Brzostek J, Hu J, Chua Y, Tung D, et al. Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice. Front Immunol. 2021;12:644483 pubmed publisher
Grishkan I, Ntranos A, Calabresi P, Gocke A. Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells. Cell Immunol. 2013;284:68-74 pubmed publisher
Gong Y, Wang Z, Liang Z, Duan H, Ouyang L, Yu Q, et al. Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells. PLoS ONE. 2012;7:e47435 pubmed publisher
Friend S, Peterson L, Kedl R, Dragone L. SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells. Immunol Res. 2013;55:116-24 pubmed publisher
Duarte J, Carrié N, Oliveira V, Almeida C, Agua Doce A, Rodrigues L, et al. T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis. J Immunol. 2012;189:1680-8 pubmed publisher
Jäger A, Dardalhon V, Sobel R, Bettelli E, Kuchroo V. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol. 2009;183:7169-77 pubmed publisher
Morris G, Allen P. Cutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease. J Immunol. 2009;182:6639-43 pubmed publisher
RICHMAN S, Aggen D, Dossett M, Donermeyer D, Allen P, Greenberg P, et al. Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments. Mol Immunol. 2009;46:902-16 pubmed publisher
Utsunomiya Y, Bill J, Palmer E, Gollob K, Takagaki Y, Kanagawa O. Analysis of a monoclonal rat antibody directed to the alpha-chain variable region (V alpha 3) of the mouse T cell antigen receptor. J Immunol. 1989;143:2602-8 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 3.2 Monoclonal Antibody (RR3-16), APC, eBioscience

Catalog # :

17-5799-82

Quantity :

100 ug

Price :

US 354.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 ug/test

Species :

Mouse

Clone :

RR3-16

Isotype :

IgG2b, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 ug/test

Aliases :

TCR V alpha3.2; TCRV alpha 3.2; TCRV alpha3.2; Va3.2; Valpha3.2