TCR V beta 5.1/5.2 Monoclonal Antibody (MR9-4), APC, eBioscience | Invitrogen 17-5796-82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 5.1/5.2 Monoclonal Antibody (MR9-4), APC, eBioscience

catalog :

17-5796-82

quantity :

100 ug

price :

US 464.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

MR9-4

application :

flow cytometry

citations: 5

Reference
Menga A, Serra M, Todisco S, Riera Domingo C, Ammarah U, Ehling M, et al. Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages. EMBO Mol Med. 2020;12:e11210 pubmed publisher
van Stipdonk M, Hardenberg G, Bijker M, Lemmens E, Droin N, Green D, et al. Dynamic programming of CD8+ T lymphocyte responses. Nat Immunol. 2003;4:361-5 pubmed
Dillon S, Jameson S, Fink P. V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition. J Immunol. 1994;152:1790-801 pubmed
Woodland D, Happ M, Bill J, Palmer E. Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells. Science. 1990;247:964-7 pubmed
Kanagawa O, Utsunomiya Y, Bill J, Palmer E, Moore M, Carbone F. Conformational difference of T cell antigen receptors revealed by monoclonal antibodies to mouse V beta 5 T cell receptor for antigen determinants. J Immunol. 1991;147:1307-14 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 5.1/5.2 Monoclonal Antibody (MR9-4), APC, eBioscience

Catalog # :

17-5796-82

Quantity :

100 ug

Price :

US 464.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 ug/test

Species :

Mouse

Clone :

MR9-4

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 ug/test

Aliases :

TCR V beta5.1; TCR V beta5.2; TCRV beta 5.1; TCRV beta 5.2; TCRV beta5.1; TCRV beta5.2; Vb5.1; Vb5.2; Vbeta5.1; Vbeta5.2