NOTCH3 Monoclonal Antibody (HMN3-133), APC, eBioscience | Invitrogen 17-5763-82 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NOTCH3 Monoclonal Antibody (HMN3-133), APC, eBioscience

catalog :

17-5763-82

quantity :

100 µg

price :

US 334

clonality :

monoclonal

host :

hamsters

conjugate :

APC

clone name :

HMN3-133

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:80; loading ...	Pribluda A, Daemen A, Lima A, Wang X, Hafner M, Poon C, et al. EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation. elife. 2022;11: pubmed publisher
	Sekine C, Moriyama Y, Koyanagi A, Koyama N, Ogata H, Okumura K, et al. Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands. Int Immunol. 2009;21:295-301 pubmed publisher
	Moriyama Y, Sekine C, Koyanagi A, Koyama N, Ogata H, Chiba S, et al. Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. Int Immunol. 2008;20:763-73 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NOTCH3 Monoclonal Antibody (HMN3-133), APC, eBioscience

Catalog # :

17-5763-82

Quantity :

100 µg

Price :

US 334

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

HMN3-133

Isotype :

IgG

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction (with its cell-bound ligands delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human. NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

AW229011; CADASIL; CADASIL1; CASIL; hpbk; IMF2; LMNS; N3; Neurogenic locus notch homolog protein 3; notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch gene homolog 3; Notch homolog 3; NOTCH3

more info or order :

Invitrogen product webpage