MARCO Monoclonal Antibody (PLK-1), APC, eBioscience | Invitrogen 17-5447-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MARCO Monoclonal Antibody (PLK-1), APC, eBioscience

catalog :

17-5447-42

quantity :

100 Tests

price :

US 402.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

PLK-1

The same clone is also sold as:

OriGene: AM26207PU-N

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Durlanik S, Fundel Clemens K, Viollet C, Huber H, Lenter M, Kitt K, et al. CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1. Sci Rep. 2021;11:14849 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MARCO Monoclonal Antibody (PLK-1), APC, eBioscience

Catalog # :

17-5447-42

Quantity :

100 Tests

Price :

US 402.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.06 ug)/test

Species :

Human

Clone :

PLK-1

Isotype :

IgG3

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

MARCO, also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family. As a part of the innate antimicrobial immune system, MARCO can bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. Due to its expression in tumor infiltrating macrophages, and its role in inhibiting immune responses within tumor environment, MARCO has been indicated as a potential target for cancer immunotherapy.

Immunogen :

Human alveolar macrophages

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.06 ug)/test

Aliases :

AI323439; Ly112; macrophage receptor MARCO; Macrophage receptor with collagenous structure; MARCO; SCARA2; Scavenger receptor class A member 2; scavenger receptor class A, member 2; SR-A6