MHC Class II I-Ad Monoclonal Antibody (AMS-32.1), APC, eBioscience | Invitrogen 17-5323-80 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MHC Class II I-Ad Monoclonal Antibody (AMS-32.1), APC, eBioscience

catalog :

17-5323-80

quantity :

25 µg

price :

US 104

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

AMS-32.1

reactivity :

mouse

application :

flow cytometry

citations: 8

Reference
Huang F, Pan N, Wei Y, Zhao J, Aldarouish M, Wang X, et al. Effects of Combinatorial Ubiquitinated Protein-Based Nanovaccine and STING Agonist in Mice With Drug-Resistant and Metastatic Breast Cancer. Front Immunol. 2021;12:707298 pubmed publisher
Korpela S, Hinz T, Oweida A, Kim J, Calhoun J, Ferris R, et al. Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response. J Transl Med. 2021;19:43 pubmed publisher
Shapiro M, Yeh W, Longfield J, Gallagher J, Infante C, Wellford S, et al. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Front Immunol. 2020;11:2180 pubmed publisher
Durán Lobato M, Carrillo Conde B, Khairandish Y, Peppas N. Surface-modified P(HEMA-co-MAA) nanogel carriers for oral vaccine delivery: design, characterization, and in vitro targeting evaluation. Biomacromolecules. 2014;15:2725-34 pubmed publisher
van der Merwe M, Abdelsamed H, Seth A, Ong T, Vogel P, Pillai A. Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation. J Immunol. 2013;191:5764-76 pubmed publisher
Yi W, Seth N, Martillotti T, Wucherpfennig K, Sant Angelo D, Denzin L. Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest. 2010;120:1324-36 pubmed publisher
Martinic M, Rülicke T, Althage A, Odermatt B, Höchli M, Lamarre A, et al. Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC. Proc Natl Acad Sci U S A. 2003;100:1861-6 pubmed
Lorber M, Loken M, Stall A, Fitch F. I-A antigens on cloned alloreactive murine T lymphocytes are acquired passively. J Immunol. 1982;128:2798-803 pubmed

product information

Product Type :

Antibody

Product Name :

MHC Class II I-Ad Monoclonal Antibody (AMS-32.1), APC, eBioscience

Catalog # :

17-5323-80

Quantity :

25 µg

Price :

US 104

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Mouse

Clone :

AMS-32.1

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; IAb; I-Abeta; major histocompatibility complex class II beta chain; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1