CD85j (ILT2) Monoclonal Antibody (HP-F1), APC, eBioscience™ | Invitrogen 17-5129-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD85j (ILT2) Monoclonal Antibody (HP-F1), APC, eBioscience™

catalog :

17-5129-42

quantity :

100 Tests

price :

US 402

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

HP-F1

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Djurisic S, Skibsted L, Hviid T. A Phenotypic Analysis of Regulatory T Cells and Uterine NK Cells from First Trimester Pregnancies and Associations with HLA-G. Am J Reprod Immunol. 2015;74:427-44 pubmed publisher
	Liu F, Cocker A, Pugh J, Djaoud Z, Parham P, Guethlein L. Natural LILRB1 D1-D2 variants show frequency differences in populations and bind to HLA class I with various avidities. Immunogenetics. 2022;74:513-525 pubmed publisher
	Perri V, Gianchecchi E, Cifaldi L, Pellegrino M, Giorda E, Andreani M, et al. Identification of GAD65 AA 114-122 reactive 'memory-like' NK cells in newly diagnosed Type 1 diabetic patients by HLA-class I pentamers. PLoS ONE. 2017;12:e0189615 pubmed publisher
	Neuper T, Ellwanger K, Schwarz H, Kufer T, Duschl A, Horejs Hoeck J. NOD1 modulates IL-10 signalling in human dendritic cells. Sci Rep. 2017;7:1005 pubmed publisher
	Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs A, et al. Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G. Oncoimmunology. 2017;6:e1250050 pubmed publisher
	Cheent K, Jamil K, Cassidy S, Liu M, Mbiribindi B, Mulder A, et al. Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. Proc Natl Acad Sci U S A. 2013;110:16981-6 pubmed publisher
	Li F, Schreeder D, Li R, Wu J, Davis R. FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation. Eur J Immunol. 2013;43:2980-92 pubmed publisher
	Li C, Tóth I, Schulze zur Wiesch J, Pereyra F, Rychert J, Rosenberg E, et al. Functional characterization of HLA-G? regulatory T cells in HIV-1 infection. PLoS Pathog. 2013;9:e1003140 pubmed publisher
	Li N, Fu L, Uchtenhagen H, Achour A, Burshtyn D. Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18. Eur J Immunol. 2013;43:1042-52 pubmed publisher
	Maloveste S, Chen D, Gostick E, Vivian J, Plishka R, Iyengar R, et al. Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cells. J Immunol. 2012;189:4338-48 pubmed publisher
	Lamar D, Weyand C, Goronzy J. Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages. Blood. 2010;115:3278-86 pubmed publisher
	Ingram W, Chan L, Guven H, Darling D, Kordasti S, Hardwick N, et al. Human CD80/IL2 lentivirus-transduced acute myeloid leukaemia (AML) cells promote natural killer (NK) cell activation and cytolytic activity: implications for a phase I clinical study. Br J Haematol. 2009;145:749-60 pubmed publisher
	Morel E, Bellón T. HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j. J Immunol. 2008;181:2368-81 pubmed
	Hernández Caselles T, Martinez Esparza M, Pérez Oliva A, Quintanilla Cecconi A, García Alonso A, Alvarez López D, et al. A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. J Leukoc Biol. 2006;79:46-58 pubmed
	Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, et al. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med. 1997;186:1809-18 pubmed

product information

Product Type :

Antibody

Product Name :

CD85j (ILT2) Monoclonal Antibody (HP-F1), APC, eBioscience™

Catalog # :

17-5129-42

Quantity :

100 Tests

Price :

US 402

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.25 µg)/test

Species :

Human

Clone :

HP-F1

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.25 µg)/test

Aliases :

CD85 antigen-like family member J; CD85j; Ig-like transcript 2; ILT2; ILT-2; Immunoglobulin-like transcript 2; leucocyte Ig-like receptor B1; leukocyte immunoglobulin like receptor B1; leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin-like receptor subfamily B member 3-like; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; LILRB1; LIR1; LIR-1; LOC100912456; MIR7; MIR-7; Monocyte/macrophage immunoglobulin-like receptor 7; myeloid inhibitory receptor 7; PIRB; PIR-B

more info or order :

Invitrogen product webpage