Arginase 1 Monoclonal Antibody (A1exF5), APC, eBioscience™ | Invitrogen 17-3697-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Arginase 1 Monoclonal Antibody (A1exF5), APC, eBioscience™

catalog :

17-3697-80

quantity :

25 µg

price :

US 144

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

A1exF5

reactivity :

human, mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:50; loading ...; fig s3b	Yang C, Lei L, Collins J, Briones M, Ma L, Sturdevant G, et al. Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor. Nat Commun. 2021;12:5454 pubmed publisher
	Brigo N, Pfeifhofer Obermair C, Demetz E, Tymoszuk P, Weiss G. Flow Cytometric Characterization of Macrophages Infected in vitro with Salmonella enterica Serovar Typhimurium Expressing Red Fluorescent Protein. Bio Protoc. 2022;12:e4440 pubmed publisher
	Gao T, Huang F, Wang W, Xie Y, Wang B. Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages. Cell Mol Biol Lett. 2022;27:27 pubmed publisher
	Dichtl S, Sanin D, Koss C, Willenborg S, Petzold A, Tanzer M, et al. Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF. Life Sci Alliance. 2022;5: pubmed publisher
	Trofimova O, Korotkaja K, Skrastina D, Jansons J, Spunde K, Isaguliants M, et al. Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model. Vaccines (Basel). 2021;9: pubmed publisher
	Dichtl S, Lindenthal L, Zeitler L, Behnke K, Schlösser D, Strobl B, et al. Lactate and IL6 define separable paths of inflammatory metabolic adaptation. Sci Adv. 2021;7: pubmed publisher
	Deng J, Tan S, Liu R, Yu W, Chen H, Tang N, et al. Chinese Medicine Formula PSORI-CM02 Alleviates Psoriatic Dermatitis via M-MDSCs and Th17 Crosstalk. Front Pharmacol. 2020;11:563433 pubmed publisher
	Hu Q, Peng J, Jiang L, Li W, Su Q, Zhang J, et al. Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. Cell Death Dis. 2020;11:925 pubmed publisher
	Mirando A, Patil A, Rafie C, Christmas B, Pandey N, Stearns V, et al. Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide. Oncoimmunology. 2020;9:1760685 pubmed publisher
	Lee H, Ko J, Kim H, Jeong H, Oh J. Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation. JCI Insight. 2020;5: pubmed publisher
	Davidson S, Efremova M, Riedel A, Mahata B, Pramanik J, Huuhtanen J, et al. Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. Cell Rep. 2020;31:107628 pubmed publisher
	Sharma M, Schlegel M, Afonso M, Brown E, RAHMAN K, Weinstock A, et al. Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression. Circ Res. 2020;127:335-353 pubmed publisher
	Lamkin D, Srivastava S, Bradshaw K, Betz J, Muy K, Wiese A, et al. C/EBPβ regulates the M2 transcriptome in β-adrenergic-stimulated macrophages. Brain Behav Immun. 2019;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Arginase 1 Monoclonal Antibody (A1exF5), APC, eBioscience™

Catalog # :

17-3697-80

Quantity :

25 µg

Price :

US 144

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1.0 µg/test

Species :

Human, Mouse

Clone :

A1exF5

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Immunogen :

E.coli-derived recombinant mouse Arginase 1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1.0 µg/test

Aliases :

AI; A-I; AI type I arginase; AI256583; ARG1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase

more info or order :

Invitrogen product webpage