CD366 (TIM3) Monoclonal Antibody (F38-2E2), APC, eBioscience™ | Invitrogen 17-3109-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD366 (TIM3) Monoclonal Antibody (F38-2E2), APC, eBioscience™

catalog :

17-3109-42

quantity :

100 Tests

price :

US 404

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

F38-2E2

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1:100; loading ...	Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562:605-609 pubmed publisher
flow cytometry; human; fig 6	Pachnio A, Ciáurriz M, Begum J, Lal N, Zuo J, Beggs A, et al. Cytomegalovirus Infection Leads to Development of High Frequencies of Cytotoxic Virus-Specific CD4+ T Cells Targeted to Vascular Endothelium. PLoS Pathog. 2016;12:e1005832 pubmed publisher
flow cytometry; human; loading ...	Weist B, Wehler P, El Ahmad L, Schmueck Henneresse M, Millward J, Nienen M, et al. A revised strategy for monitoring BKV-specific cellular immunity in kidney transplant patients. Kidney Int. 2015;88:1293-1303 pubmed publisher
	Cascone T, Leung C, Weissferdt A, Pataer A, Carter B, Godoy M, et al. Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial. Nat Med. 2023;29:593-604 pubmed publisher
	Wang X, Yu X, Li W, Neeli P, Liu M, Li L, et al. Expanding anti-CD38 immunotherapy for lymphoid malignancies. J Exp Clin Cancer Res. 2022;41:210 pubmed publisher
	Xiong J, Wang N, Zhong H, Cui B, Cheng S, Sun R, et al. SLC1A1 mediated glutamine addiction and contributed to natural killer T-cell lymphoma progression with immunotherapeutic potential. EBioMedicine. 2021;72:103614 pubmed publisher
	Yu L, Liu X, Wang X, Yan F, Wang P, Jiang Y, et al. TIGIT+ TIM-3+ NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinoma. Oncoimmunology. 2021;10:1942673 pubmed publisher
	YEKU O, Rao T, Laster I, Kononenko A, Purdon T, Wang P, et al. Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition. Front Immunol. 2021;12:663379 pubmed publisher
	Wang D, Prager B, Gimple R, Aguilar B, Alizadeh D, Tang H, et al. CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies. Cancer Discov. 2021;11:1192-1211 pubmed publisher
	Mitchell K, Diao L, Karpinets T, Negrao M, Tran H, Parra E, et al. Neutrophil expansion defines an immunoinhibitory peripheral and intratumoral inflammatory milieu in resected non-small cell lung cancer: a descriptive analysis of a prospectively immunoprofiled cohort. J Immunother Cancer. 2020;8: pubmed publisher
	Rovituso D, Scheffler L, Wunsch M, Kleinschnitz C, Dörck S, Ulzheimer J, et al. CEACAM1 mediates B cell aggregation in central nervous system autoimmunity. Sci Rep. 2016;6:29847 pubmed publisher
	Forget M, Malu S, Liu H, Toth C, Maiti S, Kale C, et al. Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma. J Immunother. 2014;37:448-60 pubmed publisher
	Ma C, Li G, Cheng Y, Wang J, Ying R, Shi L, et al. Cis association of galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling. PLoS ONE. 2013;8:e72488 pubmed publisher
	Gooden M, Wiersma V, Samplonius D, Gerssen J, van Ginkel R, Nijman H, et al. Galectin-9 activates and expands human T-helper 1 cells. PLoS ONE. 2013;8:e65616 pubmed publisher
	Hastings W, Anderson D, Kassam N, Koguchi K, Greenfield E, Kent S, et al. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009;39:2492-501 pubmed publisher
	Su E, Lin J, Kane L. TIM-1 and TIM-3 proteins in immune regulation. Cytokine. 2008;44:9-13 pubmed publisher
	Koguchi K, Anderson D, Yang L, O Connor K, Kuchroo V, Hafler D. Dysregulated T cell expression of TIM3 in multiple sclerosis. J Exp Med. 2006;203:1413-8 pubmed

product information

Product Type :

Antibody

Product Name :

CD366 (TIM3) Monoclonal Antibody (F38-2E2), APC, eBioscience™

Catalog # :

17-3109-42

Quantity :

100 Tests

Price :

US 404

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.06 µg)/test

Species :

Human

Clone :

F38-2E2

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.06 µg)/test

Aliases :

CD366; FLJ14428; Havcr2; HAVcr-2; Hepatitis A virus cellular receptor 2; hepatitis A virus cellular receptor 2 homolog; kidney injury molecule-3; KIM-3; sCD366; soluble CD366; soluble TIM 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin family member 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; TIM-3; TIMD3; TIMD-3

more info or order :

Invitrogen product webpage