CD206 (MMR) Monoclonal Antibody (19.2), APC, eBioscience | Invitrogen 17-2069-42 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD206 (MMR) Monoclonal Antibody (19.2), APC, eBioscience

catalog :

17-2069-42

quantity :

100 Tests

price :

US 347

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

19.2

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig s3l	Fan X, Guo D, Cheung A, Poon Z, Yap C, Goh S, et al. Mesenchymal Stromal Cell (MSC)-Derived Combination of CXCL5 and Anti-CCL24 Is Synergistic and Superior to MSC and Cyclosporine for the Treatment of Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2018;24:1971-1980 pubmed publisher
	Liu Y, Huang B, Lin C, Shen C, Lai S, Chen C, et al. Paliperidone Inhibits Glioblastoma Growth in Mouse Brain Tumor Model and Reduces PD-L1 Expression. Cancers (Basel). 2021;13: pubmed publisher
	Zhang G, Jiao Q, Shen C, Song H, Zhang H, Qiu Z, et al. Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer. Cancer Sci. 2021;112:997-1010 pubmed publisher
	Deng Y, Hu J, He S, Lou B, Ding T, Yang J, et al. Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer. Acta Pharmacol Sin. 2021;42:149-159 pubmed publisher
	Bharat A, Querrey M, Markov N, Kim S, Kurihara C, Garza Castillon R, et al. Lung transplantation for patients with severe COVID-19. Sci Transl Med. 2020;12: pubmed publisher
	Huang B, Liu Y, Lai S, Lin H, Shen C, Yang L, et al. CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions. Int J Mol Sci. 2020;21: pubmed publisher
	McArthur S, Juban G, Gobbetti T, Desgeorges T, Theret M, Gondin J, et al. Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation. J Clin Invest. 2020;130:1156-1167 pubmed publisher
	Bamodu O, Kuo K, Wang C, Huang W, Wu A, Tsai J, et al. Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer. Nutrients. 2019;11: pubmed publisher
	Barruet E, Morales B, Cain C, Ton A, Wentworth K, Chan T, et al. NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. JCI Insight. 2018;3: pubmed publisher
	Guo M, Xiao J, Sheng X, Zhang X, Tie Y, Wang L, et al. Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype. Front Pharmacol. 2018;9:464 pubmed publisher
	Narasimhan P, Akabas L, Tariq S, Huda N, Bennuru S, Sabzevari H, et al. Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion. PLoS Negl Trop Dis. 2018;12:e0006404 pubmed publisher
	Chiang C, Chao T, Su Y, Hsu C, Chien C, Chiu K, et al. Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-?B signaling. Oncotarget. 2017;8:20706-20718 pubmed publisher
	Johnson A, Qin Y, Cozzo A, Freemerman A, Huang M, Zhao L, et al. Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Mol Metab. 2016;5:506-526 pubmed publisher
	Su S, Zhao Q, He C, Huang D, Liu J, Chen F, et al. miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat Commun. 2015;6:8523 pubmed publisher
	Azad A, Rajaram M, Metz W, Cope F, Blue M, Vera D, et al. Î³-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206). J Immunol. 2015;195:2019-29 pubmed publisher
	He L, Marneros A. Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization. J Biol Chem. 2014;289:8019-28 pubmed publisher
	Li W, Katz B, Spinola S. Haemophilus ducreyi-induced interleukin-10 promotes a mixed M1 and M2 activation program in human macrophages. Infect Immun. 2012;80:4426-34 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD206 (MMR) Monoclonal Antibody (19.2), APC, eBioscience

Catalog # :

17-2069-42

Quantity :

100 Tests

Price :

US 347

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.06 µg)/test

Species :

Human

Clone :

19.2

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.06 µg)/test

Aliases :

AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4

more info or order :

Invitrogen product webpage