CD194 (CCR4) Monoclonal Antibody (D8SEE), APC, eBioscience™ | Invitrogen 17-1949-41 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD194 (CCR4) Monoclonal Antibody (D8SEE), APC, eBioscience™

catalog :

17-1949-41

quantity :

25Tests

price :

153.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

D8SEE

reactivity :

human

application :

flow cytometry

citations: 7

Reference
Vladimer G, Snijder B, Krall N, Bigenzahn J, Huber K, Lardeau C, et al. Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol. 2017;13:681-690 pubmed publisher
Schmidt R, Jutz S, Goldhahn K, Witzeneder N, Gerner M, Trapin D, et al. Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation. Sci Rep. 2017;7:42191 pubmed publisher
de Oliveira Pinto L, Marinho C, Povoa T, de Azeredo E, de Souza L, Barbosa L, et al. Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue fever. PLoS ONE. 2012;7:e38527 pubmed publisher
Stolberg V, Chiu B, Schmidt B, Kunkel S, Sandor M, Chensue S. CC chemokine receptor 4 contributes to innate NK and chronic stage T helper cell recall responses during Mycobacterium bovis infection. Am J Pathol. 2011;178:233-44 pubmed publisher
Sells R, Hwang S. Paradoxical increase in skin inflammation in the absence of CCR4. J Invest Dermatol. 2010;130:2697-9 pubmed publisher
Tikhonova I, Costanzi S. Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy. Curr Pharm Des. 2009;15:4003-16 pubmed
Andrew D, Ruffing N, Kim C, Miao W, Heath H, Li Y, et al. C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential. J Immunol. 2001;166:103-11 pubmed

product information

Product Type :

Antibody

Product Name :

CD194 (CCR4) Monoclonal Antibody (D8SEE), APC, eBioscience™

Catalog # :

17-1949-41

Quantity :

25Tests

Price (USD) :

153.00 USD

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.125 µg)/test

Species :

Human

Clone :

D8SEE

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.125 µg)/test

Aliases :

C-C chemokine receptor 4; C-C chemokine receptor type 4; C-C CKR-4; C-C motif chemokine receptor 4; CC-CKR-4; Ccr4; CCR-4; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; CHEMR1; ChemR13; CKR4; CMKBR4; fusin; HGCN:14099; K5-5; LESTR; leukocyte-expressed seven-transmembrane-domain receptor; MGC88293; Sdf1r