CD163 Monoclonal Antibody (eBioGHI/61 (GHI/61)), APC, eBioscience | Invitrogen 17-1639-42 product information

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product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD163 Monoclonal Antibody (eBioGHI/61 (GHI/61)), APC, eBioscience

catalog :

17-1639-42

quantity :

100 Tests

price :

US 375.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

eBioGHI/61 (GHI/61)

reactivity :

human

application :

flow cytometry

citations: 33

Reference
Yu B, de Vos D, Guo X, Peng S, Xie W, Peppelenbosch M, et al. IL-6 facilitates cross-talk between epithelial cells and tumor- associated macrophages in Helicobacter pylori-linked gastric carcinogenesis. Neoplasia. 2024;50:100981 pubmed publisher
Zhou B, Xu Y, Xu L, Kong Y, Li K, Chen B, et al. Inhibition of inflammation and infiltration of M2 macrophages in NSCLC through the ATF3/CSF1 axis: Role of miR-27a-3p. Int J Exp Pathol. 2023;104:292-303 pubmed publisher
Wang W, Li X, Qin X, Miao Y, Zhang Y, Li S, et al. Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity. Br J Haematol. 2023;202:328-343 pubmed publisher
Thaweerattanasinp T, Wanitchang A, Saenboonrueng J, Srisutthisamphan K, Wanasen N, Sungsuwan S, et al. SARS-CoV-2 Delta (B.1.617.2) variant replicates and induces syncytia formation in human induced pluripotent stem cell-derived macrophages. Peerj. 2023;11:e14918 pubmed publisher
Falc xf3 n Cama V, Montero Gonz xe1 lez T, Acosta Medina E, Guillen Nieto G, Berlanga Acosta J, Fern xe1 ndez Ortega C, et al. Evidence of SARS-CoV-2 infection in postmortem lung, kidney, and liver samples, revealing cellular targets involved in COVID-19 pathogenesis. Arch Virol. 2023;168:96 pubmed publisher
Fang J, Ou Q, Wu B, Li S, Wu M, Qiu J, et al. TcpC Inhibits M1 but Promotes M2 Macrophage Polarization via Regulation of the MAPK/NF-κB and Akt/STAT6 Pathways in Urinary Tract Infection. Cells. 2022;11: pubmed publisher
Zhao G, Ding L, Yu H, Wang W, Wang H, Hu Y, et al. M2-like tumor-associated macrophages transmit exosomal miR-27b-3p and maintain glioblastoma stem-like cell properties. Cell Death Discov. 2022;8:350 pubmed publisher
Zhang H, Wang Y, Zhao Y, Liu T, Wang Z, Zhang N, et al. PTX3 mediates the infiltration, migration, and inflammation-resolving-polarization of macrophages in glioblastoma. CNS Neurosci Ther. 2022;28:1748-1766 pubmed publisher
Yamaguchi Y, Gibson J, Ou K, Lopez L, Ng R, Leggett N, et al. PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages. J Immunother Cancer. 2022;10: pubmed publisher
Yan X, He Y, Yang S, Zeng T, Hua Y, Bao S, et al. A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and progression. Cell Death Discov. 2022;8:196 pubmed publisher
Jiang H, Zhou L, Shen N, Ning X, Wu D, Jiang K, et al. M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway. Cell Death Dis. 2022;13:183 pubmed publisher
Schimek V, Strasser K, Beer A, Göber S, Walterskirchen N, Brostjan C, et al. Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment. Cell Death Dis. 2022;13:113 pubmed publisher
Higham A, Baker J, Jackson N, Shah R, Lea S, Singh D. Dysregulation of the CD163-Haptoglobin Axis in the Airways of COPD Patients. Cells. 2021;11: pubmed publisher
Janosz E, Hetzel M, Spielmann H, Tumpara S, Rossdam C, Schwabbauer M, et al. Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo. Gene Ther. 2021;28:477-493 pubmed publisher
Zhang D, Huang J, Wang F, Ding H, Cui Y, Yang Y, et al. BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions. Cell Death Dis. 2021;12:495 pubmed publisher
Taleska Stupica G, Sostaric M, Bozhinovska M, Rupert L, Bosnić Z, Jerin A, et al. Extracorporeal Hemadsorption versus Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial. Cardiovasc Ther. 2020;2020:7834173 pubmed publisher
Schmitz T, Jannasch M, Weigel T, Moseke C, Gbureck U, Groll J, et al. Nanotopographical Coatings Induce an Early Phenotype-Specific Response of Primary Material-Resident M1 and M2 Macrophages. Materials (Basel). 2020;13: pubmed publisher
Haake K, Neehus A, Buchegger T, Kühnel M, Blank P, Philipp F, et al. Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway. Cells. 2020;9: pubmed publisher
Chen Y, Arndtz K, Webb G, Corrigan M, Akiror S, Liaskou E, et al. Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis. JHEP Rep. 2019;1:369-376 pubmed publisher
Wilcz Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, et al. Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. EMBO Mol Med. 2020;12:e10491 pubmed publisher
Wang S, Liu X, Huang R, Zheng Y, Wang N, Yang B, et al. XIAOPI Formula Inhibits Breast Cancer Stem Cells via Suppressing Tumor-Associated Macrophages/C-X-C Motif Chemokine Ligand 1 Pathway. Front Pharmacol. 2019;10:1371 pubmed publisher
Shi S, Lee E, Lin Y, Chen L, Zheng H, He X, et al. Recruitment of monocytes and epigenetic silencing of intratumoral CYP7B1 primarily contribute to the accumulation of 27-hydroxycholesterol in breast cancer. Am J Cancer Res. 2019;9:2194-2208 pubmed
Ackermann M, Kempf H, Hetzel M, Hesse C, Hashtchin A, Brinkert K, et al. Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections. Nat Commun. 2018;9:5088 pubmed publisher
Zhao X, Tang X, Guo N, An Y, Chen X, Shi C, et al. Biochanin a Enhances the Defense Against Salmonella enterica Infection Through AMPK/ULK1/mTOR-Mediated Autophagy and Extracellular Traps and Reversing SPI-1-Dependent Macrophage (MΦ) M2 Polarization. Front Cell Infect Microbiol. 2018;8:318 pubmed publisher
Wu H, Xu X, Li J, Gong J, Li M. TIM‑4 blockade of KCs combined with exogenous TGF‑β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts. Int J Mol Med. 2018;42:346-358 pubmed publisher
Yan J, Tie G, Wang S, Tutto A, DeMarco N, Khair L, et al. Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages. Nat Commun. 2018;9:33 pubmed publisher
Zhu Z, Ding J, Ma Z, Iwashina T, Tredget E. Alternatively activated macrophages derived from THP-1 cells promote the fibrogenic activities of human dermal fibroblasts. Wound Repair Regen. 2017;25:377-388 pubmed publisher
Garcia Mesa Y, Jay T, Checkley M, Luttge B, Dobrowolski C, Valadkhan S, et al. Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system. J Neurovirol. 2017;23:47-66 pubmed publisher
Liu L, Li D, Chen S, Zhao R, Pang D, Li D, et al. B7-H4 expression in human infiltrating ductal carcinoma?associated macrophages. Mol Med Rep. 2016;14:2135-42 pubmed publisher
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Law S, Micklem K, Shaw J, Zhang X, Dong Y, Willis A, et al. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur J Immunol. 1993;23:2320-5 pubmed
Pulford K, Micklem K, McCarthy S, Cordell J, Jones M, Mason D. A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4. Immunology. 1992;75:588-95 pubmed

product information

Product Type :

Antibody

Product Name :

CD163 Monoclonal Antibody (eBioGHI/61 (GHI/61)), APC, eBioscience

Catalog # :

17-1639-42

Quantity :

100 Tests

Price :

US 375.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.5 ug)/test

Species :

Human

Clone :

eBioGHI/61 (GHI/61)

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein, a member of the scavenger receptor cysteine-rich superfamily, and a receptor for the hemoglobin-haptoglobin complex. CD163 protects tissues from free hemoglobin-mediated oxidative damage, and may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. Specifically, CD163 is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhan's cells. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant. CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, and exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype. Further, CD163 also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.5 ug)/test

Aliases :

CD163; CD163 antigen; CD163 molecule; CD163v2; CD163v3; Hemoglobin scavenger receptor; M130; macrophage-associated antigen; MM130; putative CD163 antigen; SCARI1; Scavenger receptor cysteine-rich type 1 protein M130; sCD163; Soluble CD163; Soluble sCD163