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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD49d (Integrin alpha 4) Monoclonal Antibody (MRa4-1), APC, eBioscience
catalog :
17-1490-82
quantity :
100 µg
price :
US 309
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
MRa4-1
reactivity :
rat
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 6
Published Application/Species/Sample/DilutionReference
  • flow cytometry; rat; 1:50
Fu X, Tong Z, Li Q, Niu Q, Zhang Z, Tong X, et al. Induction of adipose-derived stem cells into Schwann-like cells and observation of Schwann-like cell proliferation. Mol Med Rep. 2016;14:1187-93 pubmed publisher
Wingerd K, Goodman N, Tresser J, Smail M, Leu S, Rohan S, et al. Alpha 4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart. J Neurosci. 2002;22:10772-80 pubmed
Palecanda A, Briskin M, Issekutz T. Rat mast cell lines bind to the vascular cell adhesion molecule-1 (VCAM-1) and the mucosal addressin cell adhesion molecule-1 (MAdCAM-1). J Immunol. 1997;158:2904-10 pubmed
Tsuzuki Y, Miura S, Suematsu M, Kurose I, Shigematsu T, Kimura H, et al. alpha 4 integrin plays a critical role in early stages of T lymphocyte migration in Peyer's patches of rats. Int Immunol. 1996;8:287-95 pubmed
Yasuda M, Hasunuma Y, Adachi H, Sekine C, Sakanishi T, Hashimoto H, et al. Expression and function of fibronectin binding integrins on rat mast cells. Int Immunol. 1995;7:251-8 pubmed
Springer T. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301-14 pubmed
product information
Product Type :
Antibody
Product Name :
CD49d (Integrin alpha 4) Monoclonal Antibody (MRa4-1), APC, eBioscience
Catalog # :
17-1490-82
Quantity :
100 µg
Price :
US 309
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Rat
Applications :
Flow Cytometry: 0.5 µg/test
Species :
Rat
Clone :
MRa4-1
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 µg/test
Aliases :
269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; IA4; integrin alpha 4; integrin alpha-4; integrin alpha4B; Integrin alpha-IV; integrin subunit alpha 4; integrin, alpha 4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Itga4; Itga4B; ITGA-IV; LPAM subunit alpha; lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA