This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD137 (4-1BB) Monoclonal Antibody (17B5), APC, eBioscience
catalog :
17-1371-82
quantity :
100 ug
price :
US 337.00
clonality :
monoclonal
host :
Syrian golden hamster
conjugate :
APC
clone name :
17B5

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 22
Reference
Mel xe9 ndez A, Velasco C xe1 rdenas R, Lagies S, Strietz J, Siukstaite L, Thomas O, et al. Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells. Cell Mol Life Sci. 2022;79:513 pubmed publisher
Zahm C, Moseman J, Delmastro L, G Mcneel D. PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacy. Oncoimmunology. 2021;10:1912892 pubmed publisher
Goubet A, Wheeler R, Fluckiger A, Qu B, Lemaitre F, Iribarren K, et al. Multifaceted modes of action of the anticancer probiotic Enterococcus hirae. Cell Death Differ. 2021;28:2276-2295 pubmed publisher
Bhatt D, Kang B, Sawant D, Zheng L, PEREZ K, Huang Z, et al. STARTRAC analyses of scRNAseq data from tumor models reveal T cell dynamics and therapeutic targets. J Exp Med. 2021;218: pubmed publisher
Choi E, Lee M, Song J, Kim K, Lee J, Yang J, et al. Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning. Sci Rep. 2020;10:12001 pubmed publisher
Choi H, Deng J, Li S, Silk T, Dong L, Brea E, et al. Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer. Cell Rep. 2019;27:806-819.e5 pubmed publisher
Zahm C, Colluru V, McNeel D. Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells. Cancer Immunol Res. 2017;5:630-641 pubmed publisher
Devaud C, Westwood J, John L, Flynn J, Paquet Fifield S, Duong C, et al. Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy. Mol Ther. 2014;22:18-27 pubmed publisher
Chen Y, Forsberg M, Khaja S, Ciecko A, Hessner M, Geurts A. Gene targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes. 2014;63:68-74 pubmed publisher
Lee S, Kim Y, Hwang S, Kim Y, Han I, Vinay D, et al. 4-1BB signal stimulates the activation, expansion, and effector functions of ?? T cells in mice and humans. Eur J Immunol. 2013;43:1839-48 pubmed publisher
Hagman D, Kuzma J, Larson I, Foster Schubert K, Kuan L, Cignarella A, et al. Characterizing and quantifying leukocyte populations in human adipose tissue: impact of enzymatic tissue processing. J Immunol Methods. 2012;386:50-9 pubmed publisher
Verbrugge I, Hagekyriakou J, Sharp L, Galli M, West A, McLaughlin N, et al. Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies. Cancer Res. 2012;72:3163-74 pubmed publisher
Osterbur J, Sprague L, Muccioli M, Pate M, Mansfield K, McGinty J, et al. Adhesion to substrates induces dendritic cell endothelization and decreases immunological response. Immunobiology. 2013;218:64-75 pubmed publisher
Shen C, He Y, Cheng K, Zhang D, Miao S, Zhang A, et al. Killer artificial antigen-presenting cells deplete alloantigen-specific T cells in a murine model of alloskin transplantation. Immunol Lett. 2011;138:144-55 pubmed publisher
Hamano R, Huang J, Yoshimura T, Oppenheim J, Chen X. TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40. Eur J Immunol. 2011;41:2010-20 pubmed publisher
Jiang D, Schwarz H. Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein. PLoS ONE. 2010;5:e15565 pubmed publisher
Gültner S, Kuhlmann T, Hesse A, Weber J, Riemer C, Baier M, et al. Reduced Treg frequency in LFA-1-deficient mice allows enhanced T effector differentiation and pathology in EAE. Eur J Immunol. 2010;40:3403-12 pubmed publisher
Alves B, Leong J, Tamang D, Elliott V, Edelnant J, Redelman D, et al. Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol. 2009;86:701-12 pubmed publisher
Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K, Ishikawa S. Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol. 2008;173:1682-92 pubmed publisher
Jiang D, Chen Y, Schwarz H. CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol. 2008;181:3923-32 pubmed
Shao Z, Sun F, Koh D, Schwarz H. Characterisation of soluble murine CD137 and its association with systemic lupus. Mol Immunol. 2008;45:3990-9 pubmed publisher
Zheng G, Wang B, Chen A. The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol. 2004;173:2428-34 pubmed
product information
Product Type :
Antibody
Product Name :
CD137 (4-1BB) Monoclonal Antibody (17B5), APC, eBioscience
Catalog # :
17-1371-82
Quantity :
100 ug
Price :
US 337.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Syrian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse
Clone :
17B5
Isotype :
IgG
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA