CD134 (OX40) Monoclonal Antibody (ACT35 (ACT-35)), APC, eBioscience | Invitrogen 17-1347-42 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD134 (OX40) Monoclonal Antibody (ACT35 (ACT-35)), APC, eBioscience

catalog :

17-1347-42

quantity :

100 Tests

price :

US 327.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

ACT35 (ACT-35)

reactivity :

human

application :

flow cytometry

citations: 8

Reference
Gu xe9 rin A, Moncada V xe9 lez M, Jackson K, Ogishi M, Rosain J, Mancini M, et al. Helper T cell immunity in humans with inherited CD4 deficiency. J Exp Med. 2024;221: pubmed publisher
Theodoraki M, Laban S, Jackson E, Lotfi R, Schuler P, Brunner C, et al. Changes in circulating exosome molecular profiles following surgery/(chemo)radiotherapy: early detection of response in head and neck cancer patients. Br J Cancer. 2021;125:1677-1686 pubmed publisher
Turcotte S, Gros A, Hogan K, Tran E, Hinrichs C, Wunderlich J, et al. Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy. J Immunol. 2013;191:2217-25 pubmed publisher
Kshirsagar S, Binder E, Riedl M, Wechselberger G, Steichen E, Edelbauer M. Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. Arthritis Rheum. 2013;65:2996-3006 pubmed publisher
Heninger A, Theil A, Wilhelm C, Petzold C, Huebel N, Kretschmer K, et al. IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol. 2012;189:5649-58 pubmed publisher
Pratico E, Sullenger B, Nair S. Identification and characterization of an agonistic aptamer against the T cell costimulatory receptor, OX40. Nucleic Acid Ther. 2013;23:35-43 pubmed publisher
Triplett T, Curti B, Bonafede P, Miller W, Walker E, Weinberg A. Defining a functionally distinct subset of human memory CD4+ T cells that are CD25POS and FOXP3NEG. Eur J Immunol. 2012;42:1893-905 pubmed publisher
Kashiwakura J, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho M, et al. Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest. 2012;122:218-28 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD134 (OX40) Monoclonal Antibody (ACT35 (ACT-35)), APC, eBioscience

Catalog # :

17-1347-42

Quantity :

100 Tests

Price :

US 327.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL (0.125 ug)/test

Species :

Human

Clone :

ACT35 (ACT-35)

Isotype :

IgG1, kappa

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system. When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents. OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer. They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL (0.125 ug)/test

Aliases :

ACT35; ACT35 antigen; ATC35 antigen; CD134; CD134 antigen; IMD16; Ly-70; lymphoid activation antigene ACT35; MRC OX40; Ox40; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 receptor; TNF receptor superfamily member 4; Tnfrsf4; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4; tumor necrosis factor superfamily, member 4; Txgp1; Txgp1l