This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD123 Monoclonal Antibody (5B11), APC, eBioscience
catalog :
17-1231-82
quantity :
100 ug
price :
US 325.00
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
5B11

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 7
Reference
Campbell I, Miescher S, Branch D, Mott P, Lazarus A, Han D, et al. Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils. J Immunol. 2014;192:5031-8 pubmed publisher
Khodoun M, Kucuk Z, Strait R, Krishnamurthy D, Janek K, Clay C, et al. Rapid desensitization of mice with anti-Fc?RIIb/Fc?RIII mAb safely prevents IgG-mediated anaphylaxis. J Allergy Clin Immunol. 2013;132:1375-87 pubmed publisher
Kuonen F, Laurent J, Secondini C, Lorusso G, Stehle J, Rausch T, et al. Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy. Clin Cancer Res. 2012;18:4365-74 pubmed
Anthony R, Kobayashi T, Wermeling F, Ravetch J. Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway. Nature. 2011;475:110-3 pubmed publisher
Meindl S, Schmidt U, Vaculik C, Elbe Bürger A. Characterization, isolation, and differentiation of murine skin cells expressing hematopoietic stem cell markers. J Leukoc Biol. 2006;80:816-26 pubmed
Ichihara M, Hara T, Takagi M, Cho L, Gorman D, Miyajima A. Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. EMBO J. 1995;14:939-50 pubmed
Mueller D, Chen Z, Schwartz R, Gorman D, Kennedy M. Subset of CD4+ T cell clones expressing IL-3 receptor alpha-chains uses IL-3 as a cofactor in autocrine growth. J Immunol. 1994;153:3014-27 pubmed
product information
Product Type :
Antibody
Product Name :
CD123 Monoclonal Antibody (5B11), APC, eBioscience
Catalog # :
17-1231-82
Quantity :
100 ug
Price :
US 325.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
5B11
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. IL-3Ra is responsible for the transmission of signal of Interleukin-3. IL-3Ra and IL-3Rb chain heterodimerization is induced by Interleukin-3, which is required for receptor activation but not high affinity binding. IL-3Ra is also reported that IL-3Ra subunits are overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells and are thus potential targets for novel therapeutic agents.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
CD123; CD123 antigen; CDw123; Cyrl; cytokine receptor-like protein CYRL; hIL-3Ra; Il-3 alpha subunit; IL-3 receptor alpha chain; IL-3 receptor alpha SP2 isoform; IL-3 receptor subunit alpha; IL3R; IL-3R subunit alpha; Il3ra; IL-3RA; IL-3R-alpha; IL3RAY; IL3RX; IL3RY; interleukin 3 receptor subunit alpha; interleukin 3 receptor, alpha; interleukin 3 receptor, alpha (low affinity); interleukin 3 receptor, alpha chain; interleukin-3 receptor class II alpha chain; Interleukin-3 receptor subunit alpha; Sut-1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA