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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD69 Monoclonal Antibody (H1.2F3), APC, eBioscience
catalog :
17-0691-82
quantity :
100 µg
price :
US 331.00
clonality :
monoclonal
host :
hamsters
conjugate :
APC
clone name :
H1.2F3
reactivity :
mouse
application :
flow cytometry
more info or order :
citations: 86
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...; fig 8a, 8b
Stoff M, Ebbecke T, Ciurkiewicz M, Pavasutthipaisit S, Mayer Lambertz S, St xf6 rk T, et al. C-type lectin receptor DCIR contributes to hippocampal injury in acute neurotropic virus infection. Sci Rep. 2021;11:23819 pubmed publisher
  • flow cytometry; mouse; 1:6; fig s2c
Gu C, Borjabad A, Hadas E, Kelschenbach J, Kim B, Chao W, et al. EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. PLoS Pathog. 2018;14:e1007061 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3j
Zhao J, Chen C, Guo M, Tao Y, Cui P, Zhou Y, et al. MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol. 2016;7:389 pubmed
  • flow cytometry; mouse
Pohar J, Lainšček D, Fukui R, Yamamoto C, Miyake K, Jerala R, et al. Species-Specific Minimal Sequence Motif for Oligodeoxyribonucleotides Activating Mouse TLR9. J Immunol. 2015;195:4396-405 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Joly A, Deepti A, Seignez A, Goloudina A, Hebrard S, Schmitt E, et al. The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development. Oncogene. 2016;35:2842-51 pubmed publisher
Yu L, Zhou B, Zhu Y, Li L, Zhong Y, Zhu L, et al. HSF1 promotes CD69+ Treg differentiation to inhibit colitis progression. Theranostics. 2023;13:1892-1905 pubmed publisher
Vaitaitis G, Wagner D. Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15. J Biol Chem. 2023;299:104625 pubmed publisher
Akasaka D, Iguchi S, Kaneko R, Yoshiga Y, Kajiwara D, Nakachi Y, et al. Novel Bruton's tyrosine kinase inhibitor TAS5315 suppresses the progression of inflammation and joint destruction in rodent collagen-induced arthritis. PLoS ONE. 2023;18:e0282117 pubmed publisher
Zhao J, Jia L, Tao Y, Zhao X, Yang J, Lu Y, et al. TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance. Inflamm Res. 2023;72:531-540 pubmed publisher
Kovacs M, Cowan M, Babcock I, Sibley L, Still K, Batista S, et al. Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain. elife. 2022;11: pubmed publisher
Li J, Huang F, Jiang Y, Zhao J, Wan J, Hao S. A novel costimulatory molecule gene-modified leukemia cell-derived exosome-targeted CD4+ T cell vaccine efficiently enhances anti-leukemia immunity. Front Immunol. 2022;13:1043484 pubmed publisher
Li N, Wu J, Qi M, Wang Z, Zhang S, Li X, et al. CP-25 exerts a protective effect against ConA-induced hepatitis via regulating inflammation and immune response. Front Pharmacol. 2022;13:1041671 pubmed publisher
Jiang W, Wang X, Su Y, Cai L, Li J, Liang J, et al. Intranasal Immunization With a c-di-GMP-Adjuvanted Acellular Pertussis Vaccine Provides Superior Immunity Against Bordetella pertussis in a Mouse Model. Front Immunol. 2022;13:878832 pubmed publisher
Zhang T, Wang Y, Li Q, Lin L, Xu C, Xue Y, et al. Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity. Oncogene. 2022;41:1866-1881 pubmed publisher
Basu J, Zha J, Nicolas E, Coulton M, Czyzewicz P, Hua X, et al. An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice. Commun Biol. 2022;5:84 pubmed publisher
Yu H, Yang W, Huang J, Miao X, Wang B, Ren X, et al. GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure. Cell Death Dis. 2021;13:1 pubmed publisher
Han Q, Mu Y, Zhao H, Zhao R, Guo Q, Su Y, et al. Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells. World J Gastroenterol. 2021;27:3581-3594 pubmed publisher
Sangaletti S, Botti L, Gulino A, Lecis D, Bassani B, Portararo P, et al. SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis. iScience. 2021;24:102510 pubmed publisher
Sasai M, Ma J, Okamoto M, Nishino K, Nagaoka H, Takashima E, et al. Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells. J Exp Med. 2021;218: pubmed publisher
Lin P, Liang C, Yao B, Chen H, Pan C, Wu L, et al. Robust induction of TRMs by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses. Mol Ther Methods Clin Dev. 2021;21:299-314 pubmed publisher
Kim H, Park J, Park J, Yasmin F, Kim C, Oh S, et al. Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy. J Hematol Oncol. 2021;14:43 pubmed publisher
Vonderhaar E, Barnekow N, McAllister D, McOlash L, Eid M, Riese M, et al. STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol. 2021;12:41-58 pubmed publisher
Dubois V, Chatagnon J, Thiriard A, Bauderlique Le Roy H, Debrie A, Coutte L, et al. Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage. NPJ Vaccines. 2021;6:6 pubmed publisher
Acharya T, Tiwari A, Majhi R, Goswami C. TRPM8 channel augments T-cell activation and proliferation. Cell Biol Int. 2021;45:198-210 pubmed publisher
Kim H, Park J, Fatima Y, Kausar M, Park J, Jun C. Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity. Front Immunol. 2020;11:591054 pubmed publisher
Yewdell W, Kim Y, Chowdhury P, Lau C, Smolkin R, Belcheva K, et al. A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization. Immunity. 2020;53:952-970.e11 pubmed publisher
Mao L, Zhou Y, Chen L, Hu L, Liu S, Zheng W, et al. Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury. Cell Biosci. 2020;10:121 pubmed publisher
Shao B, Wang L, Yu Y, Chen L, Gan N, Huang W. Effects of CD4+ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation. Exp Ther Med. 2020;20:84 pubmed publisher
Pasciuto E, Burton O, Roca C, Lagou V, Rajan W, Theys T, et al. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. 2020;182:625-640.e24 pubmed publisher
Li S, Liu Y, He Y, Rong W, Zhang M, Li L, et al. Podocytes present antigen to activate specific T cell immune responses in inflammatory renal disease. J Pathol. 2020;252:165-177 pubmed publisher
Liu Y, Bockermann R, Hadi M, Safari I, Carrion B, Kveiborg M, et al. ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation. Cell Mol Immunol. 2020;: pubmed publisher
Ho J, Angel M, Ma Y, Sloan E, Wang G, Martínez Romero C, et al. Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection. Cell. 2020;181:1502-1517.e23 pubmed publisher
Markman J, Porritt R, Wakita D, Lane M, Martinon D, Noval Rivas M, et al. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun. 2020;11:1613 pubmed publisher
Hajaj E, Eisenberg G, Klein S, Frankenburg S, Merims S, Ben David I, et al. SLAMF6​ deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint. elife. 2020;9: pubmed publisher
Klepsch V, Pommermayr M, Humer D, Brigo N, Hermann Kleiter N, Baier G. Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy. Cell Commun Signal. 2020;18:8 pubmed publisher
Chang L, Wang L, Ling N, Peng H, Chen M. Increase in liver γδ T cells with concurrent augmentation of IFN-β production during the early stages of a mouse model of acute experimental hepatitis B virus infection. Exp Ther Med. 2020;19:67-78 pubmed publisher
Tong D, Zhang L, Ning F, Xu Y, Hu X, Shi Y. Contact-dependent delivery of IL-2 by dendritic cells to CD4 T cells in the contraction phase promotes their long-term survival. Protein Cell. 2020;11:108-123 pubmed publisher
Leng T, Akther H, Hackstein C, Powell K, King T, Friedrich M, et al. TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions. Cell Rep. 2019;28:3077-3091.e5 pubmed publisher
Zhu X, Zhang W, Guo J, Zhang X, Li L, Wang T, et al. Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells. Cell Rep. 2019;27:1205-1220.e4 pubmed publisher
Du Q, Hoover A, Dozmorov I, Raj P, Khan S, Molina E, et al. MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary. Dev Cell. 2019;49:618-631.e5 pubmed publisher
Andersen T, Huszthy P, Gopalakrishnan R, Jacobsen J, Fauskanger M, Tveita A, et al. Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules. NPJ Vaccines. 2019;4:9 pubmed publisher
Funk K, Klein R. CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis. J Neuroinflammation. 2019;16:22 pubmed publisher
Li S, Hong Z, Wang Z, Li F, Mei J, Huang L, et al. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Rep. 2018;25:3405-3421.e7 pubmed publisher
Chan S, Filézac de L Etang A, Rangell L, Caplazi P, Lowe J, Romeo V. A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples. PLoS ONE. 2018;13:e0207619 pubmed publisher
Wilgenburg B, Loh L, Chen Z, Pediongco T, Wang H, Shi M, et al. MAIT cells contribute to protection against lethal influenza infection in vivo. Nat Commun. 2018;9:4706 pubmed publisher
Chen E, Brzostek J, Gascoigne N, Rybakin V. Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation. Sci Rep. 2018;8:10046 pubmed publisher
Weng T, Wu H, Li C, Hung Y, Chang Y, Chen Y, et al. Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation. Sci Rep. 2018;8:8216 pubmed publisher
Si Y, Wen Y, Kelly S, Chong A, Collier J. Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses. J Control Release. 2018;282:120-130 pubmed publisher
Sun C, Lan P, Han Q, Huang M, Zhang Z, Xu G, et al. Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion. Nat Commun. 2018;9:1241 pubmed publisher
Gaya M, Barral P, Burbage M, Aggarwal S, Montaner B, Warren Navia A, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172:517-533.e20 pubmed publisher
Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, et al. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27 pubmed publisher
Vonk M, Wagenaar L, Pieters R, Knippels L, Willemsen L, Smit J, et al. The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models. Clin Transl Allergy. 2017;7:35 pubmed publisher
Wang Q, Ning H, Peng H, Wei L, Hou R, Hoft D, et al. Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses. Nat Commun. 2017;8:867 pubmed publisher
Chu F, Hu Y, Zhou Y, Guo M, Lu J, Zheng W, et al. MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway. Clin Exp Immunol. 2017;: pubmed publisher
White A, Baik S, Parnell S, Holland A, Brombacher F, Jenkinson W, et al. A type 2 cytokine axis for thymus emigration. J Exp Med. 2017;214:2205-2216 pubmed publisher
de Wolf A, van Aalst S, Ludwig I, Bodinham C, Lewis D, van der Zee R, et al. Regulatory T cell frequencies and phenotypes following anti-viral vaccination. PLoS ONE. 2017;12:e0179942 pubmed publisher
Winkler H, Kornprobst J, Wick P, von Moos L, Trantakis I, Schraner E, et al. MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica. Part Fibre Toxicol. 2017;14:21 pubmed publisher
Li C, Ying W, Huang Z, Brehm T, Morin A, Vella A, et al. IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages. Endocrinology. 2017;158:2837-2847 pubmed publisher
Seignez A, Joly A, Chaumonnot K, Hazoume A, Sanka M, Marcion G, et al. Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease. JCI Insight. 2017;2:e90531 pubmed publisher
Baranek T, Morello E, Valayer A, Aimar R, Bréa D, Henry C, et al. FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection. Front Immunol. 2017;8:123 pubmed publisher
Ying W, Wollam J, Ofrecio J, Bandyopadhyay G, El Ouarrat D, Lee Y, et al. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest. 2017;127:1019-1030 pubmed publisher
Chi H, Hua K, Lin Y, Chu C, Hsieh C, Hsu Y, et al. IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis. J Am Soc Nephrol. 2017;28:2022-2037 pubmed publisher
Pohar J, Yamamoto C, Fukui R, Cajnko M, Miyake K, Jerala R, et al. Selectivity of Human TLR9 for Double CpG Motifs and Implications for the Recognition of Genomic DNA. J Immunol. 2017;198:2093-2104 pubmed publisher
Zhou Y, Weng X, Dou R, Tan X, Zhang T, Fang J, et al. Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice. Acta Pharmacol Sin. 2017;38:201-210 pubmed publisher
Fernandez Orth J, Ehling P, Ruck T, Pankratz S, Hofmann M, Landgraf P, et al. 14-3-3 Proteins regulate K2P 5.1 surface expression on T lymphocytes. Traffic. 2017;18:29-43 pubmed publisher
Allison K, Sajti E, Collier J, Gosselin D, Troutman T, Stone E, et al. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. elife. 2016;5: pubmed publisher
Menendez C, Jinkins J, Carr D. Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency. J Immunol. 2016;197:1262-75 pubmed publisher
Meininger I, Griesbach R, Hu D, Gehring T, Seeholzer T, Bertossi A, et al. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells. Nat Commun. 2016;7:11292 pubmed publisher
Tan Y, Alkhamees B, Jia D, Li L, Couture J, Figeys D, et al. MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation. Stem Cell Reports. 2015;5:741-52 pubmed publisher
Ying W, Tseng A, Chang R, Morin A, Brehm T, Triff K, et al. MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation. J Clin Invest. 2015;125:4149-59 pubmed publisher
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Binsfeld M, Beguin Y, Belle L, Otjacques E, Hannon M, Briquet A, et al. Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation. PLoS ONE. 2014;9:e113764 pubmed publisher
Hou H, Liu W, Wu S, Lu Y, Peng J, Zhu Y, et al. Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock. PLoS ONE. 2014;9:e110585 pubmed publisher
Dema B, Charles N, Pellefigues C, Ricks T, Suzuki R, Jiang C, et al. Immunoglobulin E plays an immunoregulatory role in lupus. J Exp Med. 2014;211:2159-68 pubmed publisher
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Schijf M, Kerperien J, Bastiaans J, Szklany K, Meerding J, Hofman G, et al. Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice. PLoS ONE. 2013;8:e75148 pubmed publisher
Silva Filho J, Souza M, Ferreira Dasilva C, Silva L, Costa M, Padua T, et al. Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection. PLoS ONE. 2013;8:e62999 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD69 Monoclonal Antibody (H1.2F3), APC, eBioscience
Catalog # :
17-0691-82
Quantity :
100 µg
Price :
US 331.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test
Species :
Mouse
Clone :
H1.2F3
Isotype :
IgG
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD69 (AIM, Active Inducer Molecule) is a gp28/34 disulfide bonded homodimer with a molecular weight of 60 kDa under non-reducing conditions. CD69 contains one or two N linked oligosacaride and the molecule is present on activated platelets. In normal peripheral blood a variable percentage of cells express the CD69 antigen, and it is involved in lymphocyte signal transduction. Expression CD69 is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. Alternative splicing results in multiple transcript variants of CD69. Diseases associated with CD69 dysfunction include coccidiodomycosis and asthma.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test
Aliases :
5830438K24Rik; Activation inducer molecule; activation inducer molecule (AIM/CD69); AI452015; AIM; BL-AC/P26; CD69; CD69 antigen; CD69 antigen (p60, early T-cell activation antigen); CD69 molecule; CLEC2C; C-type lectin domain family 2 member C; C-type lectin domain family 2, member C; EA1; early activation antigen CD69; early lymphocyte activation antigen; early T-cell activation antigen p60; GP32/28; leukocyte surface antigen Leu-23; MLR-3; VEA; Very Early Activation Antigen
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA