This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD63 Monoclonal Antibody (NVG-2), APC, eBioscience
catalog :
17-0631-82
quantity :
100 ug
price :
US 366.00
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
NVG-2

The same clone is also sold as:
reactivity :
mouse
application :
flow cytometry
citations: 10
Reference
Zhang Y, Li Y, Liu P, Gong D, Zhou H, Li W, et al. Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin. J Extracell Vesicles. 2021;10:e12078 pubmed publisher
Kobayashi T, Shimabukuro Demoto S, Tsutsui H, Toyama Sorimachi N. Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis. PLoS Biol. 2019;17:e3000530 pubmed publisher
Lirussi D, Ebensen T, Schulze K, Trittel S, Durán V, Liebich I, et al. Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway. EBioMedicine. 2017;22:100-111 pubmed publisher
John Lin C, Yu K, Hatcher A, Huang T, Lee H, Carlson J, et al. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017;20:396-405 pubmed publisher
Köberle M, Kaesler S, Kempf W, Wölbing F, Biedermann T. Tetraspanins in mast cells. Front Immunol. 2012;3:106 pubmed publisher
Ley K. CD63 positions CD62P for rolling. Blood. 2011;118:4012-3 pubmed publisher
Verjan Garcia N, Umemoto E, Saito Y, Yamasaki M, Hata E, Matozaki T, et al. SIRP?/CD172a regulates eosinophil homeostasis. J Immunol. 2011;187:2268-77 pubmed publisher
Duffield A, Kamsteeg E, Brown A, Pagel P, Caplan M. The tetraspanin CD63 enhances the internalization of the H,K-ATPase beta-subunit. Proc Natl Acad Sci U S A. 2003;100:15560-5 pubmed
Escola J, Kleijmeer M, Stoorvogel W, Griffith J, Yoshie O, Geuze H. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem. 1998;273:20121-7 pubmed
Maecker H, Todd S, Levy S. The tetraspanin superfamily: molecular facilitators. FASEB J. 1997;11:428-42 pubmed
product information
Product Type :
Antibody
Product Name :
CD63 Monoclonal Antibody (NVG-2), APC, eBioscience
Catalog # :
17-0631-82
Quantity :
100 ug
Price :
US 366.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 ug/test
Species :
Mouse
Clone :
NVG-2
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 ug/test
Aliases :
C75951; CD 63; Cd63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Cd63 molecule; CD63 protein; granulophysin; LAMP-3; Lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; mast cell antigen AD1; ME491; melanoma 1 antigen; melanoma-associated antigen ME491; melanoma-associated antigen MLA1; MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; TSPAN30; tspan-30
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA