CD62P (P-Selectin) Monoclonal Antibody (Psel.KO2.3), APC, eBioscience | Invitrogen 17-0626-80 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD62P (P-Selectin) Monoclonal Antibody (Psel.KO2.3), APC, eBioscience

catalog :

17-0626-80

quantity :

25 µg

price :

US 186

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

Psel.KO2.3

reactivity :

human, mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...	Cserép C, Pósfai B, Lénárt N, Fekete R, László Z, Lele Z, et al. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science. 2020;367:528-537 pubmed publisher
flow cytometry; mouse; loading ...; fig s6d	Lefrançais E, Ortiz Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah D, et al. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017;544:105-109 pubmed publisher
	Jeong S, Park J, Ryu Y, Kim W, Lee I, Kim J, et al. Myristica fragrans Extract Inhibits Platelet Desialylation and Activation to Ameliorate Sepsis-Associated Thrombocytopenia in a Murine CLP-Induced Sepsis Model. Int J Mol Sci. 2023;24: pubmed publisher
	Van Bael J, Vandenbulcke A, Ahmed Belkacem A, Guichou J, Pawlotsky J, Samyn J, et al. Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity. Int J Mol Sci. 2023;24: pubmed publisher
	Wang B, Xia M, Chen T, Li M, Shi D, Wang X, et al. Loss of Tet2 affects platelet function but not coagulation in mice. Blood Sci. 2020;2:129-136 pubmed publisher
	Peng H, Wu H, Zhang G, Zhang W, Guo Y, Chang L, et al. Expression and Clinical Prognostic Value of Platelet NLRP3 in Acute Coronary Syndrome. Int J Gen Med. 2020;13:791-802 pubmed publisher
	Ortiz Muñoz G, Yu M, Lefrançais E, Mallavia B, Valet C, Tian J, et al. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020;130:2041-2053 pubmed publisher
	Rondina M, Voora D, Simon L, Schwertz H, Harper J, Lee O, et al. Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a Platelet SELP Splice QTL. Circ Res. 2020;126:501-516 pubmed publisher
	Mendelson A, Strat A, Bao W, Rosston P, Fallon G, Ohrn S, et al. Mesenchymal stromal cells lower platelet activation and assist in platelet formation in vitro. JCI Insight. 2019;4: pubmed publisher
	Orsini F, Fumagalli S, Császár E, Toth K, De Blasio D, Zangari R, et al. Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α. Arterioscler Thromb Vasc Biol. 2018;38:2678-2690 pubmed publisher
	Qi Y, Chen W, Liang X, Xu K, Gu X, Wu F, et al. Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. J Hematol Oncol. 2018;11:117 pubmed publisher
	Liu D, Kou X, Chen C, Liu S, Liu Y, Yu W, et al. Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors. Cell Res. 2018;28:918-933 pubmed publisher
	Qiu C, Wang Y, Zhao H, Qin L, Shi Y, Zhu X, et al. The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis. Nat Commun. 2017;8:15426 pubmed publisher
	Kraakman M, Lee M, Al Sharea A, Dragoljevic D, Barrett T, Montenont E, et al. Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes. J Clin Invest. 2017;127:2133-2147 pubmed publisher
	Torres Filho I, Torres L, Valdez C, Salgado C, Cap A, Dubick M. Refrigerated platelets stored in whole blood up to 5 days adhere to thrombi formed during hemorrhagic hypotension in rats. J Thromb Haemost. 2017;15:163-175 pubmed publisher
	Vogel S, Bodenstein R, Chen Q, Feil S, Feil R, Rheinlaender J, et al. Platelet-derived HMGB1 is a critical mediator of thrombosis. J Clin Invest. 2015;125:4638-54 pubmed publisher
	Schwarzenberger C, Sradnick J, Lerea K, Goligorsky M, Nieswandt B, Hugo C, et al. Platelets are relevant mediators of renal injury induced by primary endothelial lesions. Am J Physiol Renal Physiol. 2015;308:F1238-46 pubmed publisher
	Faraday N, Schunke K, Saleem S, Fu J, Wang B, Zhang J, et al. Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils. PLoS ONE. 2013;8:e71447 pubmed publisher
	Matsumoto M, Shigeta A, Miyasaka M, Hirata T. CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner. J Immunol. 2008;181:3628-35 pubmed
	Massaguer A, Engel P, Perez Del Pulgar S, Bosch J, Pizcueta P. Production and characterization of monoclonal antibodies against conserved epitopes of P-selectin (CD62P). Tissue Antigens. 2000;56:117-28 pubmed

product information

Product Type :

Antibody

Product Name :

CD62P (P-Selectin) Monoclonal Antibody (Psel.KO2.3), APC, eBioscience

Catalog # :

17-0626-80

Quantity :

25 µg

Price :

US 186

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 0.25 µg/test

Species :

Human, Mouse

Clone :

Psel.KO2.3

Isotype :

IgG1, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type 1 transmembrane glycoprotein, and is one of the most commonly studied proteins that regulate cell rolling. P-selectin is stored in the Weibel-Palade bodies of endothelial cells, as well as in a-granules of platelets. From there, it can be rapidly brought to the cell surface after exposure to thrombin, histamine, complement 5a, Ca21 ionophores, or adenosine diphosphate. P-selectin protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. P-selectin plays an important role in adhesive processes between leucocytes and endothelial cells, and is a calcium dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens found on neutrophils and monocytes. P-selectin is constitutively expressed in inflammation and contributes to atherogenesis, thrombosis and tissue destruction. Clinically, P-selectin is used to distinguish heparin induced thrombocytopenia with and without thrombosis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test

Aliases :

CD62; CD62 antigen-like family member P; CD62P; CD62P antigen; CD62P; CD62 homolog; FLJ45155; GMP140; GMP-140; GMRP; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; Grmp; LECAM3; leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; PSEL; PSELECT; P-selectin; P-selectin precursor; RP1-86F14.2; selectin P; selectin P (granule membrane protein 140kDa, antigen CD62); selectin, platelet; Selp

more info or order :

Invitrogen product webpage