CD45RO Monoclonal Antibody (UCHL1), APC, eBioscience™ | Invitrogen 17-0457-41 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45RO Monoclonal Antibody (UCHL1), APC, eBioscience™

catalog :

17-0457-41

quantity :

25 Tests

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

UCHL1

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 42

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 3b	Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed publisher
	Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed publisher
	Alfaro C, Echeveste J, Rodriguez Ruiz M, Solorzano J, Perez Gracia J, Idoate M, et al. Functional expression of CD137 (4-1BB) on T helper follicular cells. Oncoimmunology. 2015;4:e1054597 pubmed
	Sutavani R, Bradley R, Ramage J, Jackson A, Durrant L, Spendlove I. CD55 costimulation induces differentiation of a discrete T regulatory type 1 cell population with a stable phenotype. J Immunol. 2013;191:5895-903 pubmed publisher
	Valentine M, Song K, Maresh G, Mack H, Huaman M, Polacino P, et al. Expression of the memory marker CD45RO on helper T cells in macaques. PLoS ONE. 2013;8:e73969 pubmed publisher
	Fang L, Lowther D, Meizlish M, Anderson R, Bruce J, Devine L, et al. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro Oncol. 2013;15:1479-90 pubmed publisher
	Kumar S, Naqvi R, Ali R, Rani R, Khanna N, Rao D. CD4+CD25+ T regs with acetylated FoxP3 are associated with immune suppression in human leprosy. Mol Immunol. 2013;56:513-20 pubmed publisher
	Jenks J, Seki S, Kanai T, Huang J, Morgan A, Scalco R, et al. Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells. Clin Immunol. 2013;148:227-36 pubmed publisher
	Gooden M, Wiersma V, Samplonius D, Gerssen J, van Ginkel R, Nijman H, et al. Galectin-9 activates and expands human T-helper 1 cells. PLoS ONE. 2013;8:e65616 pubmed publisher
	Kamburova E, Koenen H, Borgman K, ten Berge I, Joosten I, Hilbrands L. A single dose of rituximab does not deplete B cells in secondary lymphoid organs but alters phenotype and function. Am J Transplant. 2013;13:1503-11 pubmed publisher
	Feuth T, Arends J, Fransen J, Nanlohy N, van Erpecum K, Siersema P, et al. Complementary role of HCV and HIV in T-cell activation and exhaustion in HIV/HCV coinfection. PLoS ONE. 2013;8:e59302 pubmed publisher
	Nikiforow S, Kim H, Bindra B, McDonough S, Glotzbecker B, Armand P, et al. Phase I study of alemtuzumab for therapy of steroid-refractory chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2013;19:804-11 pubmed publisher
	Chang S, Thomas M, Sova P, Green R, Palermo R, Katze M. Next-generation sequencing of small RNAs from HIV-infected cells identifies phased microrna expression patterns and candidate novel microRNAs differentially expressed upon infection. MBio. 2013;4:e00549-12 pubmed publisher
	Na I, Wittenbecher F, Dziubianau M, Herholz A, Mensen A, Kunkel D, et al. Rabbit antithymocyte globulin (thymoglobulin) impairs the thymic output of both conventional and regulatory CD4+ T cells after allogeneic hematopoietic stem cell transplantation in adult patients. Haematologica. 2013;98:23-30 pubmed publisher
	Sage P, Varghese L, Martinelli R, Sciuto T, Kamei M, Dvorak A, et al. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol. 2012;188:3686-99 pubmed publisher
	Cuda C, Li S, Liang S, Yin Y, Potula H, Xu Z, et al. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol. 2012;188:604-14 pubmed publisher
	Fogal B, Yi T, Wang C, Rao D, Lebastchi A, Kulkarni S, et al. Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161+ CD4+ regulatory T cells. J Immunol. 2011;187:6268-80 pubmed publisher
	Simhadri V, Mariano J, Zhou Q, DeBell K, Borrego F. Differential expression of CD300a/c on human TH1 and TH17 cells. BMC Immunol. 2011;12:62 pubmed publisher
	Hildebrandt M, Dijkstra D, Gollasch H, Daemen K, Stevanovic Meyer M, Ludwig W. Apheresis-related enrichment of CD26++ T lymphocytes: phenotypic characterization and correlation with unfavorable outcome in autologous hematopoietic progenitor cell transplantation. Transfusion. 2012;52:765-76 pubmed publisher
	Aly L, Yousef S, Schippling S, Jelcic I, Breiden P, Matschke J, et al. Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome. Brain. 2011;134:2687-702 pubmed publisher
	Landrigan A, Wong M, Utz P. CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism. J Immunol. 2011;187:3033-43 pubmed publisher
	Ciccone E, Greenwald J, Lee P, Biancotto A, Read S, Yao M, et al. CD4+ T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors. J Virol. 2011;85:5880-8 pubmed publisher
	Collins A, Hewitt S, Chaumeil J, Sellars M, Micsinai M, Allinne J, et al. RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation. Immunity. 2011;34:303-14 pubmed publisher
	Mackroth M, Malhotra I, Mungai P, Koech D, Muchiri E, King C. Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigens. J Immunol. 2011;186:2780-91 pubmed publisher
	Llanos Cuentas A, Calderon W, Cruz M, Ashman J, Alves F, Coler R, et al. A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with sodium stibogluconate for the treatment of mucosal leishmaniasis. Vaccine. 2010;28:7427-35 pubmed publisher
	Kaur G, Goodall J, Jarvis L, Hill Gaston J. Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells--identification of Foxp3?7 in human regulatory T cells. Mol Immunol. 2010;48:321-32 pubmed publisher
	Narayanan S, Silva R, Peruzzi G, Alvarez Y, Simhadri V, DeBell K, et al. Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS ONE. 2010;5:e10636 pubmed publisher
	Beriou G, Bradshaw E, Lozano E, Costantino C, Hastings W, Orban T, et al. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010;185:46-54 pubmed publisher
	Huarte E, Fisher J, Turk M, Mellinger D, Foster C, Wolf B, et al. Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma. Cancer Lett. 2009;285:80-8 pubmed publisher
	Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
	Sereti I, Dunham R, Spritzler J, Aga E, Proschan M, Medvik K, et al. IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood. 2009;113:6304-14 pubmed publisher
	Gang C, Jiahui Y, Huaizhou W, Qing C, Dongbao Z, Qian S. Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4(+) and CD8(+) T-cell dysfunction in patients with active SLE. Cell Immunol. 2009;258:83-9 pubmed publisher
	Horlock C, Stott B, Dyson P, Morishita M, Coombes R, Savage P, et al. The effects of trastuzumab on the CD4+CD25+FoxP3+ and CD4+IL17A+ T-cell axis in patients with breast cancer. Br J Cancer. 2009;100:1061-7 pubmed publisher
	Thakkar N, Pirrone V, Passic S, Zhu W, Kholodovych V, Welsh W, et al. Specific interactions between the viral coreceptor CXCR4 and the biguanide-based compound NB325 mediate inhibition of human immunodeficiency virus type 1 infection. Antimicrob Agents Chemother. 2009;53:631-8 pubmed publisher
	Azevedo R, Soares M, Barata J, Tendeiro R, Serra Caetano A, Victorino R, et al. IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner. Blood. 2009;113:2999-3007 pubmed publisher
	Figueroa Tentori D, Querol S, Dodi I, Madrigal A, Duggleby R. High purity and yield of natural Tregs from cord blood using a single step selection method. J Immunol Methods. 2008;339:228-35 pubmed publisher
	Chiba H, Ishii G, Ito T, Aoyagi K, Sasaki H, Nagai K, et al. CD105-positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors. Stem Cells. 2008;26:2523-30 pubmed publisher
	Butte M, Pena Cruz V, Kim M, Freeman G, Sharpe A. Interaction of human PD-L1 and B7-1. Mol Immunol. 2008;45:3567-72 pubmed publisher
	Thakral D, Dobbins J, Devine L, Kavathas P. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. J Immunol. 2008;180:7431-42 pubmed
	van Mierlo G, Scherer H, Hameetman M, Morgan M, Flierman R, Huizinga T, et al. Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol. 2008;180:2747-51 pubmed
	Saada J, Pinchuk I, Barrera C, Adegboyega P, Suarez G, Mifflin R, et al. Subepithelial myofibroblasts are novel nonprofessional APCs in the human colonic mucosa. J Immunol. 2006;177:5968-79 pubmed
	Bossaller L, Burger J, Draeger R, Grimbacher B, Knoth R, Plebani A, et al. ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. J Immunol. 2006;177:4927-32 pubmed

product information

Product Type :

Antibody

Product Name :

CD45RO Monoclonal Antibody (UCHL1), APC, eBioscience™

Catalog # :

17-0457-41

Quantity :

25 Tests

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 5 µL (0.03 µg)/test

Species :

Human

Clone :

UCHL1

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 µL (0.03 µg)/test

Aliases :

B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen

more info or order :

Invitrogen product webpage