CD27 Monoclonal Antibody (LG.7F9), APC, eBioscience™ | Invitrogen 17-0271-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD27 Monoclonal Antibody (LG.7F9), APC, eBioscience™

catalog :

17-0271-81

quantity :

50 µg

price :

US 309.00

clonality :

monoclonal

host :

hamsters

conjugate :

APC

clone name :

LG.7F9

reactivity :

human, mouse, rat

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 1a	Karmaus P, Chen X, Lim S, Herrada A, Nguyen T, Xu B, et al. Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity. Nature. 2019;565:101-105 pubmed publisher
flow cytometry; mouse; loading ...; fig 1d	Ibitokou S, Dillon B, Sinha M, Szczesny B, Delgadillo A, Reda Abdelrahman D, et al. Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic Infection. J Immunol. 2018;200:643-656 pubmed publisher
	Vink C, Calero Nieto F, Wang X, Maglitto A, Mariani S, Jawaid W, et al. Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells. Cell Rep. 2020;31:107627 pubmed publisher
	Filskov J, Mikkelsen M, Hansen P, Christensen J, Thomsen A, Andersen P, et al. Broadening CD4+ and CD8+ T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes. J Virol. 2017;91: pubmed publisher
	Yang M, Chen S, Du J, He J, Wang Y, Li Z, et al. NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation. Nat Commun. 2016;7:12730 pubmed publisher
	Drennan M, Govindarajan S, Verheugen E, Coquet J, Staal J, McGuire C, et al. NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20. J Exp Med. 2016;213:1973-81 pubmed publisher
	Krneta T, Gillgrass A, Chew M, Ashkar A. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Cell Mol Immunol. 2016;13:628-39 pubmed publisher
	Laidlaw B, Cui W, Amezquita R, Gray S, Guan T, Lu Y, et al. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nat Immunol. 2015;16:871-9 pubmed publisher
	Zhu R, Mancini Bourgine M, Zhang X, Bayard F, Deng Q, Michel M. Plasmid vector-linked maturation of natural killer (NK) cells is coupled to antigen-dependent NK cell activation during DNA-based immunization in mice. J Virol. 2011;85:10201-12 pubmed publisher
	Hsu L, Enzler T, Seita J, Timmer A, Lee C, Lai T, et al. IL-1?-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKK?. Nat Immunol. 2011;12:144-50 pubmed publisher
	Bivas Benita M, Bar L, Gillard G, Kaufman D, Simmons N, Hovav A, et al. Efficient generation of mucosal and systemic antigen-specific CD8+ T-cell responses following pulmonary DNA immunization. J Virol. 2010;84:5764-74 pubmed publisher
	Bhattacharya D, Czechowicz A, Ooi A, Rossi D, Bryder D, Weissman I. Niche recycling through division-independent egress of hematopoietic stem cells. J Exp Med. 2009;206:2837-50 pubmed publisher
	Sheridan B, Cherpes T, Urban J, Kalinski P, Hendricks R. Reevaluating the CD8 T-cell response to herpes simplex virus type 1: involvement of CD8 T cells reactive to subdominant epitopes. J Virol. 2009;83:2237-45 pubmed publisher
	Gilfillan S, Chan C, Cella M, Haynes N, Rapaport A, Boles K, et al. DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med. 2008;205:2965-73 pubmed publisher
	Hovav A, Cayabyab M, Panas M, Santra S, Greenland J, Geiben R, et al. Rapid memory CD8+ T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis. J Virol. 2007;81:74-83 pubmed
	Chen C, Grimbaldeston M, Tsai M, Weissman I, Galli S. Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci U S A. 2005;102:11408-13 pubmed
	Taghon T, David E, Zuniga Pflucker J, Rothenberg E. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 2005;19:965-78 pubmed
	Tesselaar K, Gravestein L, van Schijndel G, Borst J, van Lier R. Characterization of murine CD70, the ligand of the TNF receptor family member CD27. J Immunol. 1997;159:4959-65 pubmed

product information

Product Type :

Antibody

Product Name :

CD27 Monoclonal Antibody (LG.7F9), APC, eBioscience™

Catalog # :

17-0271-81

Quantity :

50 µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 0.06 µg/test

Species :

Human, Mouse, Rat

Clone :

LG.7F9

Isotype :

IgG

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.06 µg/test

Aliases :

CD antigen 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; S152; S152. LPFS2; sCD27; soluble CD27; T cell activation antigen S152; T14; T-cell activation antigen CD27; TNFRSF7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7

more info or order :

Invitrogen product webpage