product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD19 Monoclonal Antibody (HIB19), APC, eBioscience™
catalog :
17-0199-41
quantity :
25 Tests
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
HIB19
reactivity :
human
application :
flow cytometry
more info or order :
citations: 97
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 5b
Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, et al. Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration. Cell Death Dis. 2020;11:973 pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
Zhu N, Wang H, Wang B, Wei J, Shan W, Feng J, et al. A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Int. 2016;2016:5687589 pubmed publisher
Tran H, Herz C, Ruf P, Stetter R, Lamy E. Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes. Front Immunol. 2018;9:2949 pubmed publisher
Annunziata P, Cioni C, Masi G, Tassi M, Marotta G, Severi S. Fingolimod reduces circulating tight-junction protein levels and in vitro peripheral blood mononuclear cells migration in multiple sclerosis patients. Sci Rep. 2018;8:15371 pubmed publisher
Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, et al. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9:1136 pubmed publisher
Böiers C, Richardson S, Laycock E, Zriwil A, Turati V, Brown J, et al. A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1. Dev Cell. 2018;44:362-377.e7 pubmed publisher
Wang W, Yan L, Liu Z, Liu L, Lin J, Liu Z, et al. HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells. Nat Commun. 2017;8:363 pubmed publisher
Magri G, Comerma L, Pybus M, Sintes J, Lligé D, Segura Garzón D, et al. Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals. Immunity. 2017;47:118-134.e8 pubmed publisher
Vladimer G, Snijder B, Krall N, Bigenzahn J, Huber K, Lardeau C, et al. Global survey of the immunomodulatory potential of common drugs. Nat Chem Biol. 2017;13:681-690 pubmed publisher
Dendrou C, Cortes A, Shipman L, Evans H, Attfield K, Jostins L, et al. Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity. Sci Transl Med. 2016;8:363ra149 pubmed
Lu X, Chen Q, Rong Y, Yang G, Li C, Xu N, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016;7:12719 pubmed publisher
Yao Y, Deng Q, Song W, Zhang H, Li Y, Yang Y, et al. MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia. Stem Cell Reports. 2016;7:249-62 pubmed publisher
Jacoby E, Nguyen S, Fountaine T, Welp K, Gryder B, Qin H, et al. CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Nat Commun. 2016;7:12320 pubmed publisher
Zhu N, Wang H, Wei J, Wang B, Shan W, Lai X, et al. NR2F2 regulates bone marrow-derived mesenchymal stem cell-promoted proliferation of Reh cells. Mol Med Rep. 2016;14:1351-6 pubmed publisher
Dou D, Calvanese V, Sierra M, Nguyen A, Minasian A, Saarikoski P, et al. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016;18:595-606 pubmed publisher
Tebbe B, Wilde B, Ye Z, Wang J, Wang X, Jian F, et al. Renal Transplant Recipients Treated with Calcineurin-Inhibitors Lack Circulating Immature Transitional CD19+CD24hiCD38hi Regulatory B-Lymphocytes. PLoS ONE. 2016;11:e0153170 pubmed publisher
Wang T, Li C, Xia C, Dong Y, Yang D, Geng Y, et al. Oncogenic NRAS hyper-activates multiple pathways in human cord blood stem/progenitor cells and promotes myelomonocytic proliferation in vivo. Am J Transl Res. 2015;7:1963-73 pubmed
Stockklausner C, Raffel S, Klermund J, Bandapalli O, Beier F, Brümmendorf T, et al. A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. Aging (Albany NY). 2015;7:911-27 pubmed
Lim S, Kim W, Kim Y, Lee S, Koo J, Lee J, et al. dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis. Nat Commun. 2015;6:8244 pubmed publisher
Corkum C, Ings D, Burgess C, Karwowska S, Kroll W, Michalak T. Immune cell subsets and their gene expression profiles from human PBMC isolated by Vacutainer Cell Preparation Tube (CPTâ„¢) and standard density gradient. BMC Immunol. 2015;16:48 pubmed publisher
Katawa G, Layland L, Debrah A, von Horn C, Batsa L, Kwarteng A, et al. Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells. PLoS Negl Trop Dis. 2015;9:e3414 pubmed publisher
Krupna Gaylord M, Liveris D, Love A, Wormser G, Schwartz I, Petzke M. Induction of type I and type III interferons by Borrelia burgdorferi correlates with pathogenesis and requires linear plasmid 36. PLoS ONE. 2014;9:e100174 pubmed publisher
Bornacelly A, Mercado D, Acevedo N, Caraballo L. The strength of the antibody response to the nematode Ascaris lumbricoides inversely correlates with levels of B-Cell Activating Factor (BAFF). BMC Immunol. 2014;15:22 pubmed publisher
Wang D, Feng X, Lu L, Konkel J, Zhang H, Chen Z, et al. A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus. Arthritis Rheumatol. 2014;66:2234-45 pubmed publisher
Ueno S, Lu J, He J, Li A, Zhang X, Ritz J, et al. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol. 2014;42:307-316.e8 pubmed publisher
Compeer E, Flinsenberg T, Boon L, Hoekstra M, Boes M. Tubulation of endosomal structures in human dendritic cells by Toll-like receptor ligation and lymphocyte contact accompanies antigen cross-presentation. J Biol Chem. 2014;289:520-8 pubmed publisher
Thiesen S, Janciauskiene S, Uronen Hansson H, Agace W, Hogerkorp C, Spee P, et al. CD14(hi)HLA-DR(dim) macrophages, with a resemblance to classical blood monocytes, dominate inflamed mucosa in Crohn's disease. J Leukoc Biol. 2014;95:531-41 pubmed publisher
Krishnan S, Wilson E, Sheikh V, Rupert A, Mendoza D, Yang J, et al. Evidence for innate immune system activation in HIV type 1-infected elite controllers. J Infect Dis. 2014;209:931-9 pubmed publisher
Abbott R, Quinn L, Leese A, Scholes H, Pachnio A, Rickinson A. CD8+ T cell responses to lytic EBV infection: late antigen specificities as subdominant components of the total response. J Immunol. 2013;191:5398-409 pubmed publisher
Lee D, Waschbisch A, Lämmer A, Doerfler A, Schwab S, Linker R. Immunological and clinical consequences of splenectomy in a multiple sclerosis patient treated with natalizumab. J Neuroinflammation. 2013;10:123 pubmed publisher
Chang J, Kim S, Koo J, Lane P, Yoon S, Park A, et al. The chronicity of tonsillitis is significantly correlated with an increase in an LTi cell portion. Inflammation. 2014;37:132-41 pubmed
Derkow K, Bauer J, Hecker M, Paap B, Thamilarasan M, Koczan D, et al. Multiple sclerosis: modulation of toll-like receptor (TLR) expression by interferon-? includes upregulation of TLR7 in plasmacytoid dendritic cells. PLoS ONE. 2013;8:e70626 pubmed publisher
Li F, Schreeder D, Li R, Wu J, Davis R. FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation. Eur J Immunol. 2013;43:2980-92 pubmed publisher
Zhang Y, Liu H, Wang L, Yang F, Hu Y, Ren X, et al. Comparative study of the cytokine/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease. PLoS ONE. 2013;8:e67430 pubmed publisher
Kwon B, Hong S, Shin K, Choi E, Hwang J, Lee S. Innate type 2 immunity is associated with eosinophilic pleural effusion in primary spontaneous pneumothorax. Am J Respir Crit Care Med. 2013;188:577-85 pubmed publisher
Pupovac A, Stokes L, Sluyter R. CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation. Purinergic Signal. 2013;9:609-19 pubmed publisher
Danso Abeam D, Zhang J, Dooley J, Staats K, Van Eyck L, Van Brussel T, et al. Olmsted syndrome: exploration of the immunological phenotype. Orphanet J Rare Dis. 2013;8:79 pubmed publisher
Lindau D, Mussard J, Wagner B, Ribon M, Rönnefarth V, Quettier M, et al. Primary blood neutrophils express a functional cell surface Toll-like receptor 9. Eur J Immunol. 2013;43:2101-13 pubmed publisher
Ueda Hayakawa I, Tanimura H, Osawa M, Iwasaka H, Ohe S, Yamazaki F, et al. Elevated serum BAFF levels in patients with sarcoidosis: association with disease activity. Rheumatology (Oxford). 2013;52:1658-66 pubmed publisher
Méndez Reguera A, Pérez Montesinos G, Alcántara Hernández M, Martínez Estrada V, Cazarin Barrientos J, Rojas Espinosa O, et al. Pathogenic CCR6+ dendritic cells in the skin lesions of discoid lupus patients: a role for damage-associated molecular patterns. Eur J Dermatol. 2013;23:169-82 pubmed publisher
Xibing G, Xiaojuan Y, Juanhua W, Zhong H. Relationship between HBV genotypes B, C and follicular helper T cells in patients with chronic hepatitis B and its significance. Hepat Mon. 2013;13:e6221 pubmed publisher
Hedges J, Kimmel E, Snyder D, Jerome M, Jutila M. Solute carrier 11A1 is expressed by innate lymphocytes and augments their activation. J Immunol. 2013;190:4263-73 pubmed publisher
Labuda L, Ateba Ngoa U, Feugap E, Heeringa J, van der Vlugt L, Pires R, et al. Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. PLoS Negl Trop Dis. 2013;7:e2094 pubmed publisher
Melton A, Melrose J, Alajoki L, Privat S, Cho H, Brown N, et al. Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation. PLoS ONE. 2013;8:e58966 pubmed publisher
Cheng Y, Yan S, Zhao W, Huang Q, Lian L, Wei W. The effect of BLyS on the activity of peripheral B lymphocytes mediated by BLyS receptors in patients with systemic lupus erythematosus. Scand J Clin Lab Invest. 2013;73:141-7 pubmed publisher
Lopatnikova J, Vasilyev F, Alshevskaya A, Sennikov S. Quantitative flow cytometric analysis of expression of tumor necrosis factor receptor types I and II on mononuclear cells. J Recept Signal Transduct Res. 2013;33:49-55 pubmed publisher
Hostmann A, Kapp K, Beutner M, Ritz J, Loddenkemper C, Ignatius R, et al. Dendritic cells from human mesenteric lymph nodes in inflammatory and non-inflammatory bowel diseases: subsets and function of plasmacytoid dendritic cells. Immunology. 2013;139:100-8 pubmed publisher
Miki Y, Gion Y, Mukae Y, Hayashi A, Sato H, Yoshino T, et al. Morphologic, flow cytometric, functional, and molecular analyses of S100B positive lymphocytes, unique cytotoxic lymphocytes containing S100B protein. Eur J Haematol. 2013;90:99-110 pubmed publisher
Vicetti Miguel R, Maryak S, Cherpes T. Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis. J Immunol Methods. 2012;384:191-5 pubmed publisher
Alkanani A, Rewers M, Dong F, Waugh K, Gottlieb P, Zipris D. Dysregulated Toll-like receptor-induced interleukin-1? and interleukin-6 responses in subjects at risk for the development of type 1 diabetes. Diabetes. 2012;61:2525-33 pubmed
Qi Y, Operario D, Georas S, Mosmann T. The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin. PLoS ONE. 2012;7:e39072 pubmed publisher
Hamilton E, Pearce L, Morgan L, Robinson S, Ware V, Brennan P, et al. Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells. Br J Haematol. 2012;158:589-99 pubmed publisher
So N, Ostrowski M, Gray Owen S. Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae. J Immunol. 2012;188:4008-22 pubmed publisher
van der Vlugt L, Labuda L, Ozir Fazalalikhan A, Lievers E, Gloudemans A, Liu K, et al. Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PLoS ONE. 2012;7:e30883 pubmed publisher
Paíno T, Ocio E, Paiva B, San Segundo L, Garayoa M, Gutierrez N, et al. CD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype. Haematologica. 2012;97:1110-4 pubmed publisher
Brindley S, Lanham A, Karrer F, Tucker R, Fontenot A, Mack C. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012;55:1130-8 pubmed publisher
Hippen K, Bucher C, Schirm D, Bearl A, Brender T, Mink K, et al. Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes. Blood. 2012;119:619-28 pubmed publisher
Gotoh K, Ito Y, Maruo S, Takada K, Mizuno T, Teranishi M, et al. Replication of Epstein-Barr virus primary infection in human tonsil tissue explants. PLoS ONE. 2011;6:e25490 pubmed publisher
Duchez S, Rodrigues M, Bertrand F, Valitutti S. Reciprocal polarization of T and B cells at the immunological synapse. J Immunol. 2011;187:4571-80 pubmed publisher
Aly L, Yousef S, Schippling S, Jelcic I, Breiden P, Matschke J, et al. Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome. Brain. 2011;134:2687-702 pubmed publisher
Landrigan A, Wong M, Utz P. CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism. J Immunol. 2011;187:3033-43 pubmed publisher
Kim S, Han S, Withers D, Gaspal F, Bae J, Baik S, et al. CD117? CD3? CD56? OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues. Eur J Immunol. 2011;41:1563-72 pubmed publisher
Petterson T, Mansson A, Riesbeck K, Cardell L. Nucleotide-binding and oligomerization domain-like receptors and retinoic acid inducible gene-like receptors in human tonsillar T lymphocytes. Immunology. 2011;133:84-93 pubmed publisher
Saiya Cork K, Collins R, Parkin B, Ouillette P, Kuizon E, Kujawski L, et al. A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. Clin Cancer Res. 2011;17:2679-92 pubmed publisher
Imbeault M, Ouellet M, Giguère K, Bertin J, Bélanger D, Martin G, et al. Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment. J Virol. 2011;85:2189-200 pubmed publisher
Andres A, Dennis M, Kretzschmar W, Cannons J, Lee Lin S, Hurle B, et al. Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet. 2010;6:e1001157 pubmed publisher
Kapp K, Maul J, Hostmann A, Mundt P, Preiss J, Wenzel A, et al. Modulation of systemic antigen-specific immune responses by oral antigen in humans. Eur J Immunol. 2010;40:3128-37 pubmed publisher
Song J, Willinger T, Rongvaux A, Eynon E, Stevens S, Manz M, et al. A mouse model for the human pathogen Salmonella typhi. Cell Host Microbe. 2010;8:369-76 pubmed publisher
Petterson T, Jendholm J, Mansson A, Bjartell A, Riesbeck K, Cardell L. Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors. J Leukoc Biol. 2011;89:177-87 pubmed publisher
Meier D, Cagnola H, Ramisch D, Rumbo C, Chirdo F, Docena G, et al. Analysis of immune cells draining from the abdominal cavity as a novel tool to study intestinal transplant immunobiology. Clin Exp Immunol. 2010;162:138-45 pubmed publisher
Gladkikh A, Potashnikova D, Korneva E, Khudoleeva O, Vorobjev I. Cyclin D1 expression in B-cell lymphomas. Exp Hematol. 2010;38:1047-57 pubmed publisher
Alvarez I, Pasquinelli V, Jurado J, Abbate E, Musella R, de la Barrera S, et al. Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis. J Infect Dis. 2010;202:524-32 pubmed publisher
Magnusson M, Brisslert M, Zendjanchi K, Lindh M, Bokarewa M. Epstein-Barr virus in bone marrow of rheumatoid arthritis patients predicts response to rituximab treatment. Rheumatology (Oxford). 2010;49:1911-9 pubmed publisher
Matthews K, Lim Z, Pearce L, Pagliuca A, Alejandro Madrigal J, Mufti G, et al. Rapid recovery of lymphocyte subsets is not associated with protection from relapse of myelodysplastic syndromes and acute myeloid leukaemia after haematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab. Br J Haematol. 2010;149:879-89 pubmed publisher
Moura R, Weinmann P, Pereira P, Caetano Lopes J, Canhao H, Sousa E, et al. Alterations on peripheral blood B-cell subpopulations in very early arthritis patients. Rheumatology (Oxford). 2010;49:1082-92 pubmed publisher
Diou J, Tardif M, Barat C, Tremblay M. Dendritic cells derived from hemozoin-loaded monocytes display a partial maturation phenotype that promotes HIV-1 trans-infection of CD4+ T cells and virus replication. J Immunol. 2010;184:2899-907 pubmed publisher
Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, et al. Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood. 2010;115:995-1005 pubmed publisher
Brudek T, Christensen T, Aagaard L, Petersen T, Hansen H, Møller Larsen A. B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity. Retrovirology. 2009;6:104 pubmed publisher
Hayes G, Busch R, Voogt J, Siah I, Gee T, Hellerstein M, et al. Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: validation of a simplified method suitable for multi-center clinical studies. Leuk Res. 2010;34:809-15 pubmed publisher
Pilling D, Vakil V, Gomer R. Improved serum-free culture conditions for the differentiation of human and murine fibrocytes. J Immunol Methods. 2009;351:62-70 pubmed publisher
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Horlock C, Stott B, Dyson J, Ogg G, McPherson T, Jones L, et al. ELISPOT and functional T cell analyses using HLA mono-specific target cells. J Immunol Methods. 2009;350:150-60 pubmed publisher
Iikuni N, Lourenço E, Hahn B, La Cava A. Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus. J Immunol. 2009;183:1518-22 pubmed publisher
Luo N, Wu Y, Chen Y, Yang Z, Guo S, Fei L, et al. Upregulated BclG(L) expression enhances apoptosis of peripheral blood CD4+ T lymphocytes in patients with systemic lupus erythematosus. Clin Immunol. 2009;132:349-61 pubmed publisher
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009;182:7518-26 pubmed publisher
Matthews K, Lim Z, Afzali B, Pearce L, Abdallah A, Kordasti S, et al. Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab. Haematologica. 2009;94:956-66 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD19 Monoclonal Antibody (HIB19), APC, eBioscience™
Catalog # :
17-0199-41
Quantity :
25 Tests
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.125 µg)/test
Species :
Human
Clone :
HIB19
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.125 µg)/test
Aliases :
AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA