product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD14 Monoclonal Antibody (61D3), APC, eBioscience™
catalog :
17-0149-42
quantity :
100 Tests
price :
US 309.00
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
61D3
reactivity :
human
application :
flow cytometry
more info or order :
citations: 130
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2a
Liu Q, Ou Q, Chen H, Gao Y, Liu Y, Xu Y, et al. Differential expression and predictive value of monocyte scavenger receptor CD163 in populations with different tuberculosis infection statuses. BMC Infect Dis. 2019;19:1006 pubmed publisher
  • flow cytometry; human; 1:20; loading ...; fig 4a
Hong D, Ding J, Li O, He Q, Ke M, Zhu M, et al. Human-induced pluripotent stem cell-derived macrophages and their immunological function in response to tuberculosis infection. Stem Cell Res Ther. 2018;9:49 pubmed publisher
  • flow cytometry; human; loading ...; fig s3a
Taylor J, Cash M, Santostefano K, Nakanishi M, Terada N, Wallet M. CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages. J Leukoc Biol. 2018;: pubmed publisher
  • flow cytometry; human; loading ...; fig s6m
Kunimoto H, Meydan C, Nazir A, Whitfield J, Shank K, Rapaport F, et al. Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity. Cancer Cell. 2018;33:44-59.e8 pubmed publisher
  • flow cytometry; human
Yoon K, Byun S, Kwon E, Hwang S, Chu K, Hiraki M, et al. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015;349:1261669 pubmed publisher
Xia Y, Gao Y, Wang B, Zhang H, Zhang Q. Optimizing the Method of Cell Separation from Bile of Patients with Cholangiocarcinoma for Flow Cytometry. Gastroenterol Res Pract. 2019;2019:5436961 pubmed publisher
Wang T, Yan R, Xu X, Yu H, Wu J, Yang Y, et al. Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells. Mol Med Rep. 2019;19:4719-4726 pubmed publisher
Huang Y, Su R, Sheng Y, Dong L, Dong Z, Xu H, et al. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell. 2019;35:677-691.e10 pubmed publisher
Tcymbarevich I, Eloranta J, Rossel J, Obialo N, Spalinger M, Cosin Roger J, et al. The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation. BMC Gastroenterol. 2019;19:2 pubmed publisher
Dagur R, Branch Woods A, Mathews S, Joshi P, Quadros R, Harms D, et al. Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection. BMC Immunol. 2019;20:2 pubmed publisher
Kan B, Michalski C, Fu H, Au H, Lee K, Marchant E, et al. Cellular metabolism constrains innate immune responses in early human ontogeny. Nat Commun. 2018;9:4822 pubmed publisher
Mohr F, Przibilla S, Leonhardt F, Stemberger C, Dreher S, Müller T, et al. Efficient immunoaffinity chromatography of lymphocytes directly from whole blood. Sci Rep. 2018;8:16731 pubmed publisher
Bera R, Chiu M, Huang Y, Liang D, Lee Y, Shih L. Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells. Neoplasia. 2018;20:1106-1120 pubmed publisher
Xiao T, Wu S, Yan C, Zhao C, Jin H, Yan N, et al. Butyrate upregulates the TLR4 expression and the phosphorylation of MAPKs and NK-κB in colon cancer cell in vitro. Oncol Lett. 2018;16:4439-4447 pubmed publisher
Siebert J, Hamann L, Verolet C, Gameiro C, Grillet S, Siegrist C, et al. Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein 180L Single-Nucleotide Polymorphism Is Associated With Susceptibility to Recurrent Pneumococcal Lower Respiratory Tract Infections in Children. Front Immunol. 2018;9:1780 pubmed publisher
Brochez L, Meireson A, Chevolet I, Sundahl N, Ost P, Kruse V. Challenging PD-L1 expressing cytotoxic T cells as a predictor for response to immunotherapy in melanoma. Nat Commun. 2018;9:2921 pubmed publisher
Adriani M, Nytrova P, Mbogning C, Hässler S, Medek K, Jensen P, et al. Monocyte NOTCH2 expression predicts IFN-β immunogenicity in multiple sclerosis patients. JCI Insight. 2018;3: pubmed publisher
Lee S, Adriani G, Ceccarello E, Pavesi A, Tan A, Bertoletti A, et al. Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model. Front Immunol. 2018;9:416 pubmed publisher
Park J, Cho H, Oh H, Kim J, Seo S. AURKA Suppresses Leukemic THP-1 Cell Differentiation through Inhibition of the KDM6B Pathway. Mol Cells. 2018;41:444-453 pubmed publisher
Ong S, Hadadi E, Dang T, Yeap W, Tan C, Ng T, et al. The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. Cell Death Dis. 2018;9:266 pubmed publisher
Ventura Ferreira M, Bienert M, Muller K, Rath B, Goecke T, Opländer C, et al. Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta. Stem Cell Res Ther. 2018;9:28 pubmed publisher
Wong T, Miller C, Jotte M, Bagegni N, Baty J, Schmidt A, et al. Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential. Nat Commun. 2018;9:455 pubmed publisher
Zhao H, Wang X, Yi P, Si Y, Tan P, He J, et al. KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression. Nat Commun. 2017;8:1428 pubmed publisher
Cunha J, Carvalho L, Bianco Junior C, Andrade M, Pratt Riccio L, Riccio E, et al. Increased Plasmodium falciparum Parasitemia in Non-splenectomized Saimiri sciureus Monkeys Treated with Clodronate Liposomes. Front Cell Infect Microbiol. 2017;7:408 pubmed publisher
Cobb D, Kim O, Golden Mason L, Rosen H, Hahn Y. Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2017;: pubmed publisher
Chang A, Dao T, Gejman R, Jarvis C, Scott A, Dubrovsky L, et al. A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens. J Clin Invest. 2017;127:2705-2718 pubmed publisher
Ménager M, Littman D. Quantitative Measurements of HIV-1 and Dextran Capture by Human Monocyte-derived Dendritic Cells (MDDCs). Bio Protoc. 2016;6: pubmed publisher
Li J, Mao Q, He J, She H, Zhang Z, Yin C. Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism. Stem Cell Res Ther. 2017;8:55 pubmed publisher
Tsai C, Lin Y, Huang C, Shih C, Tsai Y, Tsao N, et al. Thrombomodulin regulates monocye differentiation via PKC? and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016;6:38421 pubmed publisher
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Petrova P, Viller N, Wong M, Pang X, Lin G, Dodge K, et al. TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding. Clin Cancer Res. 2017;23:1068-1079 pubmed publisher
Cantoni C, Cignarella F, Ghezzi L, Mikesell B, Bollman B, Berrien Elliott M, et al. Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Acta Neuropathol. 2017;133:61-77 pubmed publisher
Lu X, Chen Q, Rong Y, Yang G, Li C, Xu N, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016;7:12719 pubmed publisher
Morton P, Hicks A, Ortiz Zapater E, Raghavan S, Pike R, Noble A, et al. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers. Sci Rep. 2016;6:26321 pubmed publisher
Natrajan M, Komori M, Kosa P, Johnson K, Wu T, Franklin R, et al. Pioglitazone regulates myelin phagocytosis and multiple sclerosis monocytes. Ann Clin Transl Neurol. 2015;2:1071-84 pubmed publisher
Hirako I, Gallego Marin C, Ataide M, Andrade W, Gravina H, Rocha B, et al. DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients. MBio. 2015;6:e01605-15 pubmed publisher
Natrajan M, de la Fuente A, Crawford A, Linehan E, Nuñez V, Johnson K, et al. Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain. 2015;138:3581-97 pubmed publisher
Sakthivel P, Grunewald J, Eklund A, Bruder D, Wahlström J. Pulmonary sarcoidosis is associated with high-level inducible co-stimulator (ICOS) expression on lung regulatory T cells--possible implications for the ICOS/ICOS-ligand axis in disease course and resolution. Clin Exp Immunol. 2016;183:294-306 pubmed publisher
Swindle E, Brown J, Radinger M, Deleo F, Metcalfe D. Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus. Immunology. 2015;146:470-85 pubmed publisher
Ly J, Lagman M, Saing T, Singh M, Tudela E, Morris D, et al. Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals. J Interferon Cytokine Res. 2015;35:875-87 pubmed publisher
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Patil S, Ogunniyi A, Calatroni A, Tadigotla V, Ruiter B, Ma A, et al. Peanut oral immunotherapy transiently expands circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects. J Allergy Clin Immunol. 2015;136:125-134.e12 pubmed publisher
Chevolet I, Speeckaert R, Schreuer M, Neyns B, Krysko O, Bachert C, et al. Characterization of the in vivo immune network of IDO, tryptophan metabolism, PD-L1, and CTLA-4 in circulating immune cells in melanoma. Oncoimmunology. 2015;4:e982382 pubmed
Lagman M, Ly J, Saing T, Kaur Singh M, Vera Tudela E, Morris D, et al. Investigating the causes for decreased levels of glutathione in individuals with type II diabetes. PLoS ONE. 2015;10:e0118436 pubmed publisher
Chevolet I, Speeckaert R, Schreuer M, Neyns B, Krysko O, Bachert C, et al. Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma. J Transl Med. 2015;13:9 pubmed publisher
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Johnston J, Nickerson J, Daroszewski J, Mogg T, Burton G. Biologically active polymers from spontaneous carotenoid oxidation: a new frontier in carotenoid activity. PLoS ONE. 2014;9:e111346 pubmed publisher
Antonelli L, Leoratti F, Costa P, Rocha B, Diniz S, Tada M, et al. The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria. PLoS Pathog. 2014;10:e1004393 pubmed publisher
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Aucher A, Rudnicka D, Davis D. MicroRNAs transfer from human macrophages to hepato-carcinoma cells and inhibit proliferation. J Immunol. 2013;191:6250-60 pubmed publisher
Ben Haij N, Leghmari K, Planès R, Thieblemont N, Bahraoui E. HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-? and IL-10. Retrovirology. 2013;10:123 pubmed publisher
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Singh V, Prajeeth C, Gudi V, Benardais K, Voss E, Stangel M. 2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells. Clin Exp Immunol. 2013;173:288-97 pubmed publisher
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Spaan M, Groothuismink Z, Koning L, Roomer R, Janssen H, de Knegt R, et al. Erythropoietin administration suppresses human monocyte function in vitro and during therapy-induced anemia in HCV patients. Antiviral Res. 2013;98:469-75 pubmed publisher
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Fossati Jimack L, Ling G, Cortini A, Szajna M, Malik T, McDonald J, et al. Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. PLoS ONE. 2013;8:e57082 pubmed publisher
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Yakubenko V, Hsi L, Cathcart M, Bhattacharjee A. From macrophage interleukin-13 receptor to foam cell formation: mechanisms for ?M?2 integrin interference. J Biol Chem. 2013;288:2778-88 pubmed publisher
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Li W, Katz B, Spinola S. Haemophilus ducreyi-induced interleukin-10 promotes a mixed M1 and M2 activation program in human macrophages. Infect Immun. 2012;80:4426-34 pubmed publisher
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Søndergaard J, Brix S. Isolation of IL-12p70-competent human monocyte-derived dendritic cells. J Immunol Methods. 2012;386:112-6 pubmed publisher
Shen C, Jia Y, Tian R, Ding M, Zhang C, Wang J. Translation of Pur-? is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection. FASEB J. 2012;26:4755-64 pubmed publisher
Son H, Kim J, Hahn Y, Seo S. Negative regulation of JAK2 by H3K9 methyltransferase G9a in leukemia. Mol Cell Biol. 2012;32:3681-94 pubmed publisher
Leoratti F, Trevelin S, Cunha F, Rocha B, Costa P, Gravina H, et al. Neutrophil paralysis in Plasmodium vivax malaria. PLoS Negl Trop Dis. 2012;6:e1710 pubmed publisher
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McGovern J, Nguyen D, Notley C, Mauri C, Isenberg D, Ehrenstein M. Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy. Arthritis Rheum. 2012;64:3129-38 pubmed publisher
Bjerg L, Brosbøl Ravnborg A, Tørring C, Dige A, Bundgaard B, Petersen T, et al. Altered frequency of T regulatory cells is associated with disability status in relapsing-remitting multiple sclerosis patients. J Neuroimmunol. 2012;249:76-82 pubmed publisher
Ambarus C, Noordenbos T, de Hair M, Tak P, Baeten D. Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis. Arthritis Res Ther. 2012;14:R74 pubmed publisher
Nair A, Kanda V, Bush Joseph C, Verma N, Chubinskaya S, Mikecz K, et al. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. Arthritis Rheum. 2012;64:2268-77 pubmed publisher
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Osterholt H, Lundeland B, Sonerud T, Saugstad O, Nakstad B. The impact of hyaluronan on monocyte Toll-like receptor expression in term infant cord blood. Acta Paediatr. 2012;101:706-13 pubmed publisher
Liverani E, Banerjee S, Roberts W, Naseem K, Perretti M. Prednisolone exerts exquisite inhibitory properties on platelet functions. Biochem Pharmacol. 2012;83:1364-73 pubmed publisher
Zhang Y, Morgan M, Chen K, Choksi S, Liu Z. Induction of autophagy is essential for monocyte-macrophage differentiation. Blood. 2012;119:2895-905 pubmed publisher
Santer D, Wiedeman A, Teal T, Ghosh P, Elkon K. Plasmacytoid dendritic cells and C1q differentially regulate inflammatory gene induction by lupus immune complexes. J Immunol. 2012;188:902-15 pubmed publisher
Brindley S, Lanham A, Karrer F, Tucker R, Fontenot A, Mack C. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012;55:1130-8 pubmed publisher
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Landrigan A, Wong M, Utz P. CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism. J Immunol. 2011;187:3033-43 pubmed publisher
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Li W, Katz B, Spinola S. Haemophilus ducreyi lipooligosaccharides induce expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase via type I interferons and tumor necrosis factor alpha in human dendritic cells. Infect Immun. 2011;79:3338-47 pubmed publisher
Peng C, Liu B, de Knegt R, Janssen H, Boonstra A. The response to TLR ligation of human CD16?CD14? monocytes is weakly modulated as a consequence of persistent infection with the hepatitis C virus. Mol Immunol. 2011;48:1505-11 pubmed publisher
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Kina K, Masuda H, Nakayama H, Nagatsuka Y, Nabetani T, Hirabayashi Y, et al. The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. J Immunol. 2011;186:5323-32 pubmed publisher
von Scheele I, Larsson K, Dahlen B, Billing B, Skedinger M, Lantz A, et al. Toll-like receptor expression in smokers with and without COPD. Respir Med. 2011;105:1222-30 pubmed publisher
Zhang Y, Li J, Lou J, Zhou Y, Bo L, Zhu J, et al. Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients. Crit Care. 2011;15:R70 pubmed publisher
Kwajah M M S, Mustafa N, Holme A, Pervaiz S, Schwarz H. Biphasic activity of CD137 ligand-stimulated monocytes on T cell apoptosis and proliferation. J Leukoc Biol. 2011;89:707-20 pubmed publisher
Lammers K, Khandelwal S, Chaudhry F, Kryszak D, Puppa E, Casolaro V, et al. Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease. Immunology. 2011;132:432-40 pubmed publisher
Kapp K, Maul J, Hostmann A, Mundt P, Preiss J, Wenzel A, et al. Modulation of systemic antigen-specific immune responses by oral antigen in humans. Eur J Immunol. 2010;40:3128-37 pubmed publisher
Hu H, Zhu L, Huang Z, Ji Q, Chatterjee M, Zhang W, et al. Platelets enhance lymphocyte adhesion and infiltration into arterial thrombus. Thromb Haemost. 2010;104:1184-92 pubmed publisher
Zhang H, Zhao C, Li X, Zhu Y, Gan C, Wang Y, et al. Study of monocyte membrane proteome perturbation during lipopolysaccharide-induced tolerance using iTRAQ-based quantitative proteomic approach. Proteomics. 2010;10:2780-9 pubmed publisher
Sahlander K, Larsson K, Palmberg L. Increased serum levels of soluble ST2 in birch pollen atopics and individuals working in laboratory animal facilities. J Occup Environ Med. 2010;52:214-8 pubmed publisher
Clancy R, Alvarez D, Komissarova E, Barrat F, Swartz J, Buyon J. Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block. J Immunol. 2010;184:2148-55 pubmed publisher
Marino J, Tan C, Taylor A, Bentley C, Van De Wiele C, Ranne R, et al. Differential IL-7 responses in developing human thymocytes. Hum Immunol. 2010;71:329-33 pubmed publisher
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Wang W, Xu M, Zhang Y, He B. Fenoterol, a beta(2)-adrenoceptor agonist, inhibits LPS-induced membrane-bound CD14, TLR4/CD14 complex, and inflammatory cytokines production through beta-arrestin-2 in THP-1 cell line. Acta Pharmacol Sin. 2009;30:1522-8 pubmed publisher
ten Berge B, Muskens F, Kleinjan A, Hammad H, Hoogsteden H, Lambrecht B, et al. A novel method for isolating dendritic cells from human bronchoalveolar lavage fluid. J Immunol Methods. 2009;351:13-23 pubmed publisher
Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, et al. Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders. Blood. 2009;114:3208-15 pubmed publisher
Jin Z, Nagakubo D, Shirakawa A, Nakayama T, Shigeta A, Hieshima K, et al. CXCR7 is inducible by HTLV-1 Tax and promotes growth and survival of HTLV-1-infected T cells. Int J Cancer. 2009;125:2229-35 pubmed publisher
Shinoda Y, Hieda K, Koyanagi Y, Suzuki Y. Efficient transduction of cytotoxic and anti-HIV-1 genes by a gene-regulatable lentiviral vector. Virus Genes. 2009;39:165-75 pubmed publisher
Svensson M. Isolation and culture of human hematopoietic progenitors for studies of dendritic cell biology. Methods Mol Biol. 2009;531:187-202 pubmed publisher
Shun C, Yeh C, Chang C, Wu S, Lien H, Chen J, et al. Activation of human valve interstitial cells by a viridians streptococci modulin induces chemotaxis of mononuclear cells. J Infect Dis. 2009;199:1488-96 pubmed publisher
Conroy A, Serghides L, Finney C, Owino S, Kumar S, Gowda D, et al. C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. PLoS ONE. 2009;4:e4953 pubmed publisher
Cupedo T, Crellin N, Papazian N, Rombouts E, Weijer K, Grogan J, et al. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol. 2009;10:66-74 pubmed publisher
Schmid M, Varner J. Chapter 15. Methods to study myeloid cell roles in angiogenesis. Methods Enzymol. 2008;445:343-71 pubmed publisher
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product information
Product Type :
Antibody
Product Name :
CD14 Monoclonal Antibody (61D3), APC, eBioscience™
Catalog # :
17-0149-42
Quantity :
100 Tests
Price :
US 309.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: 5 µL (0.25 µg)/test
Species :
Human
Clone :
61D3
Isotype :
IgG1, kappa
Storage :
4° C, store in dark, DO NOT FREEZE!
Description :
CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 µL (0.25 µg)/test
Aliases :
CD 14; CD14; CD14 antigen; CD14 molecule; cd14 monocyte; lipopolysaccharide receptor; lipoprotein receptor; LPSR antibody; monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14, membrane-bound form; Monocyte differentiation antigen CD14, urinary form; monocyte differentiation antigen CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein; myeloid membrane glycoprotein precursor; sCD14; soluble CD14
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA