This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD14 Monoclonal Antibody (Sa2-8), APC, eBioscience
catalog :
17-0141-82
quantity :
100 ug
price :
US 377.00
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
Sa2-8
reactivity :
mouse
application :
flow cytometry
citations: 51
Reference
Wang M, Lkhagva E, Kim S, Zhai C, Islam M, Kim H, et al. The gut microbe pair of Oribacterium sp. GMB0313 and Ruminococcus sp. GMB0270 confers complete protection against SARS-CoV-2 infection by activating CD8+ T cell-mediated immunity. Gut Microbes. 2024;16:2342497 pubmed publisher
Liu C, Guo S, Liu R, Guo M, Wang Q, Chai Z, et al. Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis. Neural Regen Res. 2024;19:671-679 pubmed publisher
Wang Y, Jing L, Lei X, Ma Z, Li B, Shi Y, et al. Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition. Stem Cell Res Ther. 2023;14:257 pubmed publisher
Liu T, Huang T, Li J, Li A, Li C, Huang X, et al. Optimization of differentiation and transcriptomic profile of THP-1 cells into macrophage by PMA. PLoS ONE. 2023;18:e0286056 pubmed publisher
Lee S, Lee H, Lee K, Kim M, Kang S, Lee Y, et al. CD8α+ dendritic cells potentiate antitumor and immune activities against murine ovarian cancers. Sci Rep. 2023;13:98 pubmed publisher
Boyce M, Xin Y, Chowdhury O, Shang P, Liu H, Koontz V, et al. Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model. Cells. 2022;11: pubmed publisher
Wu Y, Fan X, Yu H, Liu J, Duan Y, Zhang S, et al. Macrophage polarization is involved in liver fibrosis induced by β 1-adrenoceptor autoantibody. Acta Biochim Biophys Sin (Shanghai). 2022;54:1100-1112 pubmed publisher
Flamant M, Mougenot N, Balse E, Le Fevre L, Atassi F, Gautier E, et al. Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure. Sci Rep. 2021;11:17982 pubmed publisher
Shen T, Chen C, Jhan M, Tseng P, Lin C. CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain. Front Cell Infect Microbiol. 2020;10:557610 pubmed publisher
Xue J, Xu L, Zhu H, Bai M, Li X, Zhao Z, et al. CD14+CD16- monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK. Arthritis Res Ther. 2020;22:221 pubmed publisher
Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d Errico P, et al. A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity. 2019;50:1482-1497.e7 pubmed publisher
Aloor J, Azzam K, Guardiola J, Gowdy K, Madenspacher J, Gabor K, et al. Leucine-rich repeats and calponin homology containing 4 (Lrch4) regulates the innate immune response. J Biol Chem. 2019;294:1997-2008 pubmed publisher
Xiao T, Wu S, Yan C, Zhao C, Jin H, Yan N, et al. Butyrate upregulates the TLR4 expression and the phosphorylation of MAPKs and NK-κB in colon cancer cell in vitro. Oncol Lett. 2018;16:4439-4447 pubmed publisher
Schappe M, Desai B. Measurement of TLR4 and CD14 Receptor Endocytosis Using Flow Cytometry. Bio Protoc. 2018;8: pubmed publisher
Wu H, Xu X, Li J, Gong J, Li M. TIM‑4 blockade of KCs combined with exogenous TGF‑β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts. Int J Mol Med. 2018;42:346-358 pubmed publisher
Bi L, Sun L, Jin Z, Zhang S, Shen Z. MicroRNA-10a/b are regulators of myeloid differentiation and acute myeloid leukemia. Oncol Lett. 2018;15:5611-5619 pubmed publisher
Schappe M, Szteyn K, Stremska M, Mendu S, Downs T, Seegren P, et al. Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation. Immunity. 2018;48:59-74.e5 pubmed publisher
Pal B, Chen Y, Vaillant F, Jamieson P, Gordon L, Rios A, et al. Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling. Nat Commun. 2017;8:1627 pubmed publisher
Zanoni I, Tan Y, Di Gioia M, Springstead J, Kagan J. By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation. Immunity. 2017;47:697-709.e3 pubmed publisher
Mossadegh Keller N, Gentek R, Gimenez G, Bigot S, Mailfert S, Sieweke M. Developmental origin and maintenance of distinct testicular macrophage populations. J Exp Med. 2017;214:2829-2841 pubmed publisher
Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel M, et al. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016;7:292-305 pubmed publisher
Baliram R, Latif R, Morshed S, Zaidi M, Davies T. T3 Regulates a Human Macrophage-Derived TSH-? Splice Variant: Implications for Human Bone Biology. Endocrinology. 2016;157:3658-67 pubmed publisher
Park K, Mima A, Li Q, Rask Madsen C, He P, Mizutani K, et al. Insulin decreases atherosclerosis by inducing endothelin receptor B expression. JCI Insight. 2016;1: pubmed
Tan Y, Zanoni I, Cullen T, Goodman A, Kagan J. Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria. Immunity. 2015;43:909-22 pubmed publisher
Thiele M, Kerschbaumer R, Tam F, Völkel D, Douillard P, Schinagl A, et al. Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions. J Immunol. 2015;195:2343-52 pubmed publisher
Tran C, Stary C, Schilling J, Bentley B, Patel H, Roth D. Role of caveolin-3 in lymphocyte activation. Life Sci. 2015;121:35-9 pubmed publisher
Merritt P, Nero T, Bohman L, Felek S, Krukonis E, Marketon M. Yersinia pestis targets neutrophils via complement receptor 3. Cell Microbiol. 2015;17:666-87 pubmed publisher
Crane M, Daley J, Van Houtte O, Brancato S, Henry W, Albina J. The monocyte to macrophage transition in the murine sterile wound. PLoS ONE. 2014;9:e86660 pubmed publisher
Roehrich M, Spicher A, Milano G, Vassalli G. Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity. Biomed Res Int. 2013;2013:503047 pubmed publisher
Navarro Alvarez N, Yang Y. Lack of CD47 on donor hepatocytes promotes innate immune cell activation and graft loss: a potential barrier to hepatocyte xenotransplantation. Cell Transplant. 2014;23:345-54 pubmed publisher
Jux B, Staratschek Jox A, Penninger J, Schultze J, Kolanus W. Vav1 regulates MHCII expression in murine resting and activated B cells. Int Immunol. 2013;25:307-17 pubmed publisher
Hagman D, Kuzma J, Larson I, Foster Schubert K, Kuan L, Cignarella A, et al. Characterizing and quantifying leukocyte populations in human adipose tissue: impact of enzymatic tissue processing. J Immunol Methods. 2012;386:50-9 pubmed publisher
Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek Burchardt M, Achilles J, et al. Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS ONE. 2011;6:e17314 pubmed publisher
Marchlik E, Thakker P, Carlson T, Jiang Z, Ryan M, Marusic S, et al. Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol. 2010;88:1171-80 pubmed publisher
Tanaka C, Fujimoto M, Hamaguchi Y, Sato S, Takehara K, Hasegawa M. Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway. Arthritis Rheum. 2010;62:1723-32 pubmed publisher
Miellot Gafsou A, Biton J, Bourgeois E, Herbelin A, Boissier M, Bessis N. Early activation of invariant natural killer T cells in a rheumatoid arthritis model and application to disease treatment. Immunology. 2010;130:296-306 pubmed publisher
Oliva C, Turnbough C, Kearney J. CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages. Proc Natl Acad Sci U S A. 2009;106:13957-62 pubmed publisher
Tse M, Lane C, Mott K, Onlamoon N, Hsiao H, Perng G. ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection. J Neuroimmunol. 2009;213:12-9 pubmed publisher
Cui J, Zhu N, Wang Q, Yu M, Feng J, Li Y, et al. p38 MAPK contributes to CD54 expression and the enhancement of phagocytic activity during macrophage development. Cell Immunol. 2009;256:6-11 pubmed publisher
Blumenthal A, Kobayashi T, Pierini L, Banaei N, Ernst J, Miyake K, et al. RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins. Cell Host Microbe. 2009;5:35-46 pubmed publisher
Sun Q, Jin H, Bond J. Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells. Exp Hematol. 2009;37:346-56 pubmed publisher
Nemoto E, Honda T, Kanaya S, Takada H, Shimauchi H. Expression of functional Toll-like receptors and nucleotide-binding oligomerization domain proteins in murine cementoblasts and their upregulation during cell differentiation. J Periodontal Res. 2008;43:585-93 pubmed publisher
Brake D, Smith C. Flow cytometry on the stromal-vascular fraction of white adipose tissue. Methods Mol Biol. 2008;456:221-9 pubmed publisher
Zhu N, Cui J, Qiao C, Li Y, Ma Y, Zhang J, et al. cAMP modulates macrophage development by suppressing M-CSF-induced MAPKs activation. Cell Mol Immunol. 2008;5:153-7 pubmed publisher
Wu X, Yu G, Parks H, Hebert T, Goh B, Dietrich M, et al. Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure. Bone. 2008;42:861-70 pubmed publisher
Wang R, Braughton K, Kretschmer D, Bach T, Queck S, Li M, et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med. 2007;13:1510-4 pubmed
Peng J, Kitchen S, West R, Sigler R, Eisenmann K, Alberts A. Myeloproliferative defects following targeting of the Drf1 gene encoding the mammalian diaphanous related formin mDia1. Cancer Res. 2007;67:7565-71 pubmed
Petursdottir D, Hardardottir I. Dietary fish oil increases the number of splenic macrophages secreting TNF-alpha and IL-10 but decreases the secretion of these cytokines by splenic T cells from mice. J Nutr. 2007;137:665-70 pubmed
Turner J, Langley R, Johnston K, Egerton G, Wanji S, Taylor M. Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner. J Immunol. 2006;177:1240-9 pubmed
Brake D, Smith E, Mersmann H, Smith C, Robker R. ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice. Am J Physiol Cell Physiol. 2006;291:C1232-9 pubmed
Akashi S, Saitoh S, Wakabayashi Y, Kikuchi T, Takamura N, Nagai Y, et al. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med. 2003;198:1035-42 pubmed
product information
Product Type :
Antibody
Product Name :
CD14 Monoclonal Antibody (Sa2-8), APC, eBioscience
Catalog # :
17-0141-82
Quantity :
100 ug
Price :
US 377.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.5 ug/test
Species :
Mouse
Clone :
Sa2-8
Isotype :
IgG2a, kappa
Storage :
4 C, store in dark, DO NOT FREEZE!
Description :
CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.5 ug/test
Aliases :
CD 14; CD14; CD14 antigen; CD14 molecule; cd14 monocyte; lipopolysaccharide receptor; lipoprotein receptor; LPSR antibody; monocyte differentiation antigen CD14; Monocyte differentiation antigen CD14, membrane-bound form; Monocyte differentiation antigen CD14, urinary form; monocyte differentiation antigen CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein; myeloid membrane glycoprotein precursor; sCD14; soluble CD14
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA