CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), APC, eBioscience | Invitrogen 17-0083-81 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), APC, eBioscience

catalog :

17-0083-81

quantity :

50 µg

price :

US 182

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

eBioH35-17.2 (H35-17.2)

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 28

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 1a, 1b	Lu L, Li T, Feng X, Liu Z, Liu Y, Chao T, et al. Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice. PLoS Pathog. 2022;18:e1010596 pubmed publisher
flow cytometry; mouse; loading ...; fig 4c, 5c	Cornelissen L, Blanas A, van der Horst J, Kruijssen L, Zaal A, O Toole T, et al. Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis. Int J Cancer. 2019;144:2290-2302 pubmed publisher
flow cytometry; mouse	Jurkin J, Henkel T, Nielsen A, Minnich M, Popow J, Kaufmann T, et al. The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells. EMBO J. 2014;33:2922-36 pubmed publisher
flow cytometry; mouse; fig 2	Harimoto H, Shimizu M, Nakagawa Y, Nakatsuka K, Wakabayashi A, Sakamoto C, et al. Inactivation of tumor-specific CD8? CTLs by tumor-infiltrating tolerogenic dendritic cells. Immunol Cell Biol. 2013;91:545-55 pubmed publisher
	Lin Y, Liu S, Wu W, Shen Y, Wang Y, Liao C, et al. miR-4759 suppresses breast cancer through immune checkpoint blockade. Comput Struct Biotechnol J. 2022;20:241-251 pubmed publisher
	Weng H, Huang H, Wu H, Qin X, Zhao B, Dong L, et al. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2018;22:191-205.e9 pubmed publisher
	Yoshizawa A, Bi K, Keskin D, Zhang G, Reinhold B, Reinherz E. TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells. Eur J Immunol. 2018;48:128-150 pubmed publisher
	Macpherson K, Sompol P, Kannarkat G, Chang J, Sniffen L, Wildner M, et al. Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice. Neurobiol Dis. 2017;102:81-95 pubmed publisher
	Zamarin D, Holmgaard R, Ricca J, Plitt T, Palese P, Sharma P, et al. Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity. Nat Commun. 2017;8:14340 pubmed publisher
	Chen L, Yi X, Goswami S, Ahn Y, Roybal J, Yang Y, et al. Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression. Oncoimmunology. 2016;5:e1234570 pubmed publisher
	Gravano D, Al Kuhlani M, Davini D, Sanders P, Manilay J, Hoyer K. CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure. J Autoimmun. 2016;75:58-67 pubmed publisher
	Gabriel S, Bon N, Chen J, Wekerle T, Bushell A, Fehr T, et al. Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance. Front Immunol. 2016;7:73 pubmed publisher
	Wu L, Wu M, DE LA MAZA L, Yun Z, Yu J, Zhao Y, et al. Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model. Oncotarget. 2015;6:12468-80 pubmed
	Wang H, Sun R, Li Y, Yang Y, Xiao F, Zhang Y, et al. HGF Gene Modification in Mesenchymal Stem Cells Reduces Radiation-Induced Intestinal Injury by Modulating Immunity. PLoS ONE. 2015;10:e0124420 pubmed publisher
	Liu G, Sun D, Wu H, Zhang M, Huan H, Xu J, et al. Distinct Contributions of CD4+ and CD8+ T Cells to Pathogenesis of Trypanosoma brucei Infection in the Context of Gamma Interferon and Interleukin-10. Infect Immun. 2015;83:2785-95 pubmed publisher
	Chen L, Gibbons D, Goswami S, Cortez M, Ahn Y, Byers L, et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun. 2014;5:5241 pubmed publisher
	Pioli P, Dahlem T, Weis J, Weis J. Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency. PLoS ONE. 2013;8:e69216 pubmed publisher
	Carrero J, Calderon B, Towfic F, Artyomov M, Unanue E. Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse. PLoS ONE. 2013;8:e59701 pubmed publisher
	Park S, Jing X, Gupta D, Dziarski R. Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. J Immunol. 2013;190:3480-92 pubmed publisher
	Bouvier I, Jusforgues Saklani H, Lim A, Lemaitre F, Lemercier B, Auriau C, et al. Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery. Front Immunol. 2011;2:71 pubmed publisher
	Li Z, Huang H, Li Y, Jiang X, Chen P, Arnovitz S, et al. Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. Blood. 2012;119:2314-24 pubmed publisher
	Iyori M, Zhang T, Pantel H, Gagne B, Sentman C. TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells. J Immunol. 2011;187:3087-95 pubmed publisher
	Giannattasio G, Ohta S, Boyce J, Xing W, Balestrieri B, Boyce J. The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation. J Immunol. 2011;187:1486-95 pubmed publisher
	Menzel U, Ktistaki E, Tolaini M, Veiga Fernandes H, Kioussis D. Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages. Proc Natl Acad Sci U S A. 2010;107:16928-33 pubmed publisher
	Shang L, Thirunarayanan N, Viejo Borbolla A, Martin A, Bogunovic M, Marchesi F, et al. Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine. Gastroenterology. 2009;137:1006-18, 1018.e1-3 pubmed publisher
	Thoma Uszynski S, Emoto M, Kaufmann S. CD8alphaalpha T cells in lesions of Listeria monocytogenes-infected beta2m-deficient mice. Microb Pathog. 1997;23:101-6 pubmed
	Tarleton R, Sun J, Zhang L, Postan M. Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas' disease. Infect Immun. 1994;62:1820-9 pubmed
	Lefrancois L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J Immunol. 1991;147:1746-51 pubmed

product information

Product Type :

Antibody

Product Name :

CD8b Monoclonal Antibody (eBioH35-17.2 (H35-17.2)), APC, eBioscience

Catalog # :

17-0083-81

Quantity :

50 µg

Price :

US 182

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.5 µg/test

Species :

Mouse

Clone :

eBioH35-17.2 (H35-17.2)

Isotype :

IgG2b, kappa

Storage :

4° C, store in dark, DO NOT FREEZE!

Description :

The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.5 µg/test

Aliases :

CD8; CD8 antigen 37 kDa chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8a; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; CD8B1; CD8beta; CD8BP; LEU2; Leu-2; LY3; Ly-3; Ly-C; Lymphocyte antigen 3; Lyt3; Lyt-3; MAL; OX-8 membrane antigen; p32; P37; T lymphocyte surface glycoprotein beta chain; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-3

more info or order :

Invitrogen product webpage