CD278 (ICOS) Monoclonal Antibody (C398.4A), Functional Grade, eBioscience | Invitrogen 16-9949-050 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD278 (ICOS) Monoclonal Antibody (C398.4A), Functional Grade, eBioscience

catalog :

16-9949-050

quantity :

50 mg

price :

US 13750

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

C398.4A

reactivity :

mouse, rat, rhesus macaque

application :

flow cytometry

citations: 8

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 6e	Gryzik S, Hoang Y, Lischke T, Mohr E, Venzke M, Kadner I, et al. Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception. elife. 2020;9: pubmed publisher
	Schrock D, Leddon S, Hughson A, Miller J, Lacy Hulbert A, Fowell D. Pivotal role for αV integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
	Knolle M, Chin S, Rana B, Englezakis A, Nakagawa R, Fallon P, et al. MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity. Front Immunol. 2018;9:2232 pubmed publisher
	Cho S, Lee H, Yu I, Choi Y, Huang H, Hashemifar S, et al. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 2018;9:2757 pubmed publisher
	Hao Y, Wang Y, Liu X, Yang X, Wang P, Tian Q, et al. The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4+ T Cells During Viral Infection. Front Immunol. 2018;9:1127 pubmed publisher
	Gullicksrud J, Li F, Xing S, Zeng Z, Peng W, Badovinac V, et al. Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection. J Immunol. 2017;199:911-919 pubmed publisher
	Brahmakshatriya V, Kuang Y, Devarajan P, Xia J, Zhang W, Vong A, et al. IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo. J Immunol. 2017;198:2819-2833 pubmed publisher
	Stone E, Pepper M, Katayama C, Kerdiles Y, Lai C, Emslie E, et al. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 2015;42:239-251 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD278 (ICOS) Monoclonal Antibody (C398.4A), Functional Grade, eBioscience

Catalog # :

16-9949-050

Quantity :

50 mg

Price :

US 13750

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Armenian Hamster

Reactivity :

Mouse, Rat, Rhesus Monkey

Applications :

Flow Cytometry: 0.25 µg/test, Functional Assay: Assay-Dependent

Species :

Mouse, Rat, Rhesus Monkey

Clone :

C398.4A

Isotype :

IgG

Storage :

4° C

Description :

CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 µg/test, Functional Assay: Assay-Dependent

Aliases :

Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115