This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TLR4/MD-2 Complex Monoclonal Antibody (MTS510), Functional Grade, eBioscience
catalog :
16-9924-38
quantity :
5 mg
price :
US 3075.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
MTS510

The same clone is also sold as:
reactivity :
mouse
application :
neutralization, flow cytometry
citations: 19
Reference
Hu J, Wang X, Chen X, Fang Y, Chen K, Peng W, et al. Hydroxychloroquine attenuates neuroinflammation following traumatic brain injury by regulating the TLR4/NF-κB signaling pathway. J Neuroinflammation. 2022;19:71 pubmed publisher
Choi J, Lim J, Kim H. Lycopene Inhibits Toll-Like Receptor 4-Mediated Expression of Inflammatory Cytokines in House Dust Mite-Stimulated Respiratory Epithelial Cells. Molecules. 2021;26: pubmed publisher
Quirino Teixeira A, Rozini S, Barbosa Lima G, Coelho D, Carneiro P, Mohana Borges R, et al. Inflammatory signaling in dengue-infected platelets requires translation and secretion of nonstructural protein 1. Blood Adv. 2020;4:2018-2031 pubmed publisher
Yan N, Wen D, Zhao Y, Xu S. Epimedium sagittatum inhibits TLR4/MD-2 mediated NF-κB signaling pathway with anti-inflammatory activity. BMC Complement Altern Med. 2018;18:303 pubmed publisher
Schappe M, Szteyn K, Stremska M, Mendu S, Downs T, Seegren P, et al. Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation. Immunity. 2018;48:59-74.e5 pubmed publisher
Shen W, Zhou J, Wang C, Xu G, Wu Y, Hu Z. High mobility group box 1 induces calcification of aortic valve interstitial cells via toll-like receptor 4. Mol Med Rep. 2017;15:2530-2536 pubmed publisher
Kumazoe M, Nakamura Y, Yamashita M, Suzuki T, Takamatsu K, Huang Y, et al. Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216. J Biol Chem. 2017;292:4077-4088 pubmed publisher
Balusu S, Van Wonterghem E, De Rycke R, Raemdonck K, Stremersch S, Gevaert K, et al. Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles. EMBO Mol Med. 2016;8:1162-1183 pubmed publisher
de La Serre C, de Lartigue G, Raybould H. Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons. Physiol Behav. 2015;139:188-94 pubmed publisher
Yang K, Zhang X, Cao L, Liu X, Liu Z, Wang X, et al. Toll-like receptor 4 mediates inflammatory cytokine secretion in smooth muscle cells induced by oxidized low-density lipoprotein. PLoS ONE. 2014;9:e95935 pubmed publisher
Chang W, Liu J, Liu C, Liu W, Lim Y, Cheng Y, et al. An extract of Rhodobacter sphaeroides reduces cisplatin-induced nephrotoxicity in mice. Toxins (Basel). 2013;5:2353-65 pubmed publisher
Casella C, Mitchell T. Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A. PLoS ONE. 2013;8:e62622 pubmed publisher
Van De Voort T, Felder M, Yang R, Sondel P, Rakhmilevich A. Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice. J Immunother. 2013;36:29-40 pubmed publisher
Herrmann M, Schafer C, Heiss A, Gräber S, Kinkeldey A, Büscher A, et al. Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A. Circ Res. 2012;111:575-84 pubmed publisher
Chen G, Hwang S, Su H, Kuo C, Luo W, Lo K, et al. Defective antiviral responses of induced pluripotent stem cells to baculoviral vector transduction. J Virol. 2012;86:8041-9 pubmed publisher
Slesiona S, Gressler M, Mihlan M, Zaehle C, Schaller M, Barz D, et al. Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages. PLoS ONE. 2012;7:e31223 pubmed publisher
Filardy A, Pires D, Nunes M, Takiya C, Freire de Lima C, Ribeiro Gomes F, et al. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J Immunol. 2010;185:2044-50 pubmed publisher
Chabot S, Wagner J, Farrant S, Neutra M. TLRs regulate the gatekeeping functions of the intestinal follicle-associated epithelium. J Immunol. 2006;176:4275-83 pubmed
Chen D, Texada D, Duggan C, Liang C, Reden T, Kooragayala L, et al. Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells. J Biol Chem. 2005;280:22425-36 pubmed
product information
Product Type :
Antibody
Product Name :
TLR4/MD-2 Complex Monoclonal Antibody (MTS510), Functional Grade, eBioscience
Catalog # :
16-9924-38
Quantity :
5 mg
Price :
US 3075.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Species :
Mouse
Clone :
MTS510
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Aliases :
ARMD10; CD284; Esop1; ESOP-1; hToll; lipopolysaccharide response; Lps; Ly87; Ly96; Ly-96; Lymphocyte antigen 96; Md2; MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; Toll-like receptor 4
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA