This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD281 (TLR1) Monoclonal Antibody (GD2.F4), Functional Grade, eBioscience
catalog :
16-9911-82
quantity :
100 ug
price :
US 389.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
GD2.F4

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
citations: 16
Reference
He Q, Yu C, Wu G, Wang K, Ni Y, Guo X, et al. A novel alternative for pyrogen detection based on a transgenic cell line. Signal Transduct Target Ther. 2024;9:33 pubmed publisher
Giannakopoulos S, Strange D, Jiyarom B, Abdelaal O, Bradshaw A, Nerurkar V, et al. In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury. PLoS Pathog. 2023;19:e1011409 pubmed publisher
Harbuzariu A, Nti A, Harp K, Cespedes J, Driss A, Stiles J. Neuregulin-1/ErbB4 signaling modulates Plasmodium falciparum HRP2-induced damage to brain cortical organoids. iScience. 2022;25:104407 pubmed publisher
da Rocha Sobrinho H, Saar Gomes R, da Silva D, Quixabeira V, Joosten L, Ribeiro De Barros Cardoso C, et al. Toll-like receptor 10 controls TLR2-induced cytokine production in monocytes from patients with Parkinson's disease. J Neurosci Res. 2021;99:2511-2524 pubmed publisher
Bzowska M, Nogieć A, Bania K, Zygmunt M, Zarebski M, Dobrucki J, et al. Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages. J Leukoc Biol. 2017;102:763-774 pubmed publisher
Snodgrass R, Huang S, Choi I, Rutledge J, Hwang D. Inflammasome-mediated secretion of IL-1? in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol. 2013;191:4337-47 pubmed publisher
Ranoa D, Kelley S, Tapping R. Human lipopolysaccharide-binding protein (LBP) and CD14 independently deliver triacylated lipoproteins to Toll-like receptor 1 (TLR1) and TLR2 and enhance formation of the ternary signaling complex. J Biol Chem. 2013;288:9729-41 pubmed publisher
Hart B, Tapping R. Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria. J Immunol. 2012;189:5347-55 pubmed publisher
Colmont C, Raby A, Dioszeghy V, LeBouder E, Foster T, Jones S, et al. Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors. Nephrol Dial Transplant. 2011;26:4079-90 pubmed publisher
Zhu J, Krishnegowda G, Li G, Gowda D. Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1. Exp Parasitol. 2011;128:205-11 pubmed publisher
Lin Y, Liang Y, Tseng Y, Huang H, Chou S, Hseu R, et al. An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and MAPK pathways. J Leukoc Biol. 2009;86:877-89 pubmed publisher
Peiser M, Koeck J, Kirschning C, Wittig B, Wanner R. Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity. J Leukoc Biol. 2008;83:1118-27 pubmed publisher
Razonable R, Henault M, Watson H, Paya C. Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism. Antimicrob Agents Chemother. 2005;49:3546-9 pubmed
Razonable R, Henault M, Lee L, Laethem C, Johnston P, Watson H, et al. Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2. Antimicrob Agents Chemother. 2005;49:1617-21 pubmed
Han S, Kim J, Martin M, Michalek S, Nahm M. Pneumococcal lipoteichoic acid (LTA) is not as potent as staphylococcal LTA in stimulating Toll-like receptor 2. Infect Immun. 2003;71:5541-8 pubmed
Sandor F, Latz E, Re F, Mandell L, Repik G, Golenbock D, et al. Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling. J Cell Biol. 2003;162:1099-110 pubmed
product information
Product Type :
Antibody
Product Name :
CD281 (TLR1) Monoclonal Antibody (GD2.F4), Functional Grade, eBioscience
Catalog # :
16-9911-82
Quantity :
100 ug
Price :
US 389.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Control: Assay-Dependent, Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Species :
Human
Clone :
GD2.F4
Isotype :
IgG1, kappa
Storage :
4 C
Description :
TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
Format :
Liquid
Applications w/Dilutions :
Control: Assay-Dependent, Flow Cytometry: 1 ug/test, Functional Assay: Assay-Dependent
Aliases :
CD281; KIAA0012; rsc786; TIL; TIL. LPRS5; TLR1; toll like receptor 1; Toll/interleukin-1 receptor-like protein; toll-like receptor 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA