CD284 (TLR4) Monoclonal Antibody (HT52), Functional Grade, eBioscience | Invitrogen 16-9879-85 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD284 (TLR4) Monoclonal Antibody (HT52), Functional Grade, eBioscience

catalog :

16-9879-85

quantity :

500 ug

price :

US 574.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HT52

reactivity :

human

application :

flow cytometry

citations: 8

Reference
van Montfoort N, van der Aa E, van den Bosch A, Brouwers H, Vanwolleghem T, Janssen H, et al. Hepatitis B Virus Surface Antigen Activates Myeloid Dendritic Cells via a Soluble CD14-Dependent Mechanism. J Virol. 2016;90:6187-6199 pubmed publisher
Salvi V, Scutera S, Rossi S, Zucca M, Alessandria M, Greco D, et al. Dual regulation of osteopontin production by TLR stimulation in dendritic cells. J Leukoc Biol. 2013;94:147-58 pubmed publisher
Kanevskiy L, Telford W, Sapozhnikov A, Kovalenko E. Lipopolysaccharide induces IFN-? production in human NK cells. Front Immunol. 2013;4:11 pubmed publisher
de Graaf R, Kloppenburg G, Kitslaar P, Bruggeman C, Stassen F. Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4. Microbes Infect. 2006;8:1859-65 pubmed
Mirlashari M, Lyberg T. Expression and involvement of Toll-like receptors (TLR)2, TLR4, and CD14 in monocyte TNF-alpha production induced by lipopolysaccharides from Neisseria meningitidis. Med Sci Monit. 2003;9:BR316-24 pubmed
Tabeta K, Yamazaki K, Akashi S, Miyake K, Kumada H, Umemoto T, et al. Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts. Infect Immun. 2000;68:3731-5 pubmed
Akashi S, Ogata H, Kirikae F, Kirikae T, Kawasaki K, Nishijima M, et al. Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2. Biochem Biophys Res Commun. 2000;268:172-7 pubmed
Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med. 1999;189:1777-82 pubmed

product information

Product Type :

Antibody

Product Name :

CD284 (TLR4) Monoclonal Antibody (HT52), Functional Grade, eBioscience

Catalog # :

16-9879-85

Quantity :

500 ug

Price :

US 574.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 0.25 ug/test, Functional Assay: Assay-Dependent

Species :

Human

Clone :

HT52

Isotype :

IgG1

Storage :

4 C

Description :

TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.25 ug/test, Functional Assay: Assay-Dependent

Aliases :

ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein