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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Ly-6G Monoclonal Antibody (1A8-Ly6g), Functional Grade, eBioscience
catalog :
16-9668-85
quantity :
500 µg
price :
US 359.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
1A8-Ly6g
reactivity :
mouse
application :
flow cytometry, blocking or activating experiments
more info or order :
citations: 55
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig s4
Neuper T, Neureiter D, Sarajlic M, Strandt H, Bauer R, Schwarz H, et al. IL-31 transgenic mice show reduced allergen-induced lung inflammation. Eur J Immunol. 2021;51:191-196 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4
Kim K, Lee J, Ahn S, Won R, Kim S, Jeong S, et al. The methanol extract of Guettarda speciosa Linn. Ameliorates acute lung injury in mice. BMC Complement Med Ther. 2020;20:40 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3h
Chu C, Murdock M, Jing D, Won T, Chung H, Kressel A, et al. The microbiota regulate neuronal function and fear extinction learning. Nature. 2019;574:543-548 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Perry C, Muñoz Rojas A, Meeth K, Kellman L, Amezquita R, Thakral D, et al. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. J Exp Med. 2018;215:877-893 pubmed publisher
  • blocking or activating experiments; mouse; loading ...; fig s4a
Nishi H, Furuhashi K, Cullere X, Saggu G, Miller M, Chen Y, et al. Neutrophil Fc?RIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases. J Clin Invest. 2017;127:3810-3826 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2h
Deniset J, Surewaard B, Lee W, Kubes P. Splenic Ly6Ghigh mature and Ly6Gint immature neutrophils contribute to eradication of S. pneumoniae. J Exp Med. 2017;214:1333-1350 pubmed publisher
  • flow cytometry; mouse; fig 4
Meliopoulos V, Van De Velde L, Van De Velde N, Karlsson E, Neale G, Vogel P, et al. An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens. PLoS Pathog. 2016;12:e1005804 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3f
Crosby E, Clark M, Novais F, Wherry E, Scott P. Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. J Immunol. 2015;195:3301-10 pubmed publisher
Wang S, Zhang Q, Lu D, Fang Y, Yan X, Chen J, et al. GPR84 regulates pulmonary inflammation by modulating neutrophil functions. Acta Pharmacol Sin. 2023;44:1665-1675 pubmed publisher
Zhao T, Liu S, Hanna N, Jalal S, Ding X, Wan J, et al. LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer. J Immunother Cancer. 2023;11: pubmed publisher
Bernis M, Zweyer M, Maes E, Schleehuber Y, Sabir H. Neutrophil Extracellular Traps Release following Hypoxic-Ischemic Brain Injury in Newborn Rats Treated with Therapeutic Hypothermia. Int J Mol Sci. 2023;24: pubmed publisher
Sandri S, Hebeda C, Broering M, de Paula Silva M, Moredo L, de Barros E Silva M, et al. Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis. Cells. 2023;12: pubmed publisher
DeMarco J, Royal J, Severson W, Gabbard J, Hume S, Morton J, et al. CoV-RBD121-NP Vaccine Candidate Protects against Symptomatic Disease following SARS-CoV-2 Challenge in K18-hACE2 Mice and Induces Protective Responses That Prevent COVID-19-Associated Immunopathology. Vaccines (Basel). 2021;9: pubmed publisher
Callejas B, Blyth G, Jendzjowsky N, Wang A, Babbar A, Koro K, et al. Interleukin-4 Programmed Macrophages Suppress Colitis and Do Not Enhance Infectious-Colitis, Inflammation-Associated Colon Cancer or Airway Hypersensitivity. Front Immunol. 2021;12:744738 pubmed publisher
Somebang K, Rudolph J, Imhof I, Li L, Niemi E, Shigenaga J, et al. CCR2 deficiency alters activation of microglia subsets in traumatic brain injury. Cell Rep. 2021;36:109727 pubmed publisher
Manriquez V, Nivoit P, Urbina T, Echenique Rivera H, Melican K, Fernandez gerlinger M, et al. Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils. Nat Commun. 2021;12:4547 pubmed publisher
Lee S, Yang H, Kim W, Lee Y, Lee W, Kong S, et al. STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer. J Immunother Cancer. 2021;9: pubmed publisher
Sun S, Ni S, Li Y, Liu X, Deng J, Chen Z, et al. G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence. Cell Death Dis. 2021;12:594 pubmed publisher
Gusarova G, Das S, Islam M, Westphalen K, Jin G, Shmarakov I, et al. Actin fence therapy with exogenous V12Rac1 protects against acute lung injury. JCI Insight. 2021;6: pubmed publisher
Tan Z, Chiu M, Yan C, Man K, Chen Z. Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment. Mol Ther Oncolytics. 2021;20:373-386 pubmed publisher
Vonderhaar E, Barnekow N, McAllister D, McOlash L, Eid M, Riese M, et al. STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol. 2021;12:41-58 pubmed publisher
Guo Q, Zhao Y, Li J, Liu J, Yang X, Guo X, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021;29:222-235.e4 pubmed publisher
Kawanishi N, Machida S. Alterations of macrophage and neutrophil content in skeletal muscle of aged versus young mice. Muscle Nerve. 2021;63:600-607 pubmed publisher
Jin Z, Sun J, Song Z, Chen K, Nicolas Y, Kc R, et al. Neutrophil extracellular traps promote scar formation in post-epidural fibrosis. NPJ Regen Med. 2020;5:19 pubmed publisher
Bhaskaran N, Faddoul F, Paes da Silva A, Jayaraman S, Schneider E, Mamileti P, et al. IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging. Front Immunol. 2020;11:595936 pubmed publisher
Fang Y, Gu Y, Li L, Zhu L, Qian J, Zhao C, et al. Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b+Ly6G- myeloid cells. Aging (Albany NY). 2020;12:25673-25683 pubmed publisher
Si Y, Tian Q, Zhao F, Kelly S, Shores L, Camacho D, et al. Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses. Sci Adv. 2020;6:eaba0995 pubmed publisher
Ma C, Yang D, Wang B, Wu C, Wu Y, Li S, et al. Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation. Sci Adv. 2020;6:eaaz6717 pubmed publisher
Nuti E, Rossello A, Cuffaro D, Camodeca C, Van Bael J, van der Maat D, et al. Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms. Cells. 2020;9: pubmed publisher
Kumaraswami K, Salei N, Beck S, Rambichler S, Kluever A, Lasch M, et al. A Simple and Effective Flow Cytometry-Based Method for Identification and Quantification of Tissue Infiltrated Leukocyte Subpopulations in a Mouse Model of Peripheral Arterial Disease. Int J Mol Sci. 2020;21: pubmed publisher
Liu T, Yang L, Han X, Ding X, Li J, Yang J. Local sympathetic innervations modulate the lung innate immune responses. Sci Adv. 2020;6:eaay1497 pubmed publisher
Tan Z, Chiu M, Yan C, Wong Y, Huang H, Man K, et al. Antimesothelioma Immunotherapy by CTLA-4 Blockade Depends on Active PD1-Based TWIST1 Vaccination. Mol Ther Oncolytics. 2020;16:302-317 pubmed publisher
Hiroki C, Toller Kawahisa J, Fumagalli M, Cólon D, Figueiredo L, Fonseca B, et al. Neutrophil Extracellular Traps Effectively Control Acute Chikungunya Virus Infection. Front Immunol. 2019;10:3108 pubmed publisher
Park M, Kim H, Lee H, Zabel B, Bae Y. Novel CD11b+Gr-1+Sca-1+ myeloid cells drive mortality in bacterial infection. Sci Adv. 2020;6:eaax8820 pubmed publisher
Rowe S, Wagner N, Li L, Beam J, Wilkinson A, Radlinski L, et al. Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection. Nat Microbiol. 2020;5:282-290 pubmed publisher
Shi L, Wang J, Ding N, Zhang Y, Zhu Y, Dong S, et al. Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Nat Commun. 2019;10:5421 pubmed publisher
Gao W, Zhang X, Yang W, Dou D, Zhang H, Tang Y, et al. Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells. J Immunother Cancer. 2019;7:231 pubmed publisher
De Cicco P, Ercolano G, Rubino V, Terrazzano G, Ruggiero G, Cirino G, et al. Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects. Br J Pharmacol. 2020;177:884-897 pubmed publisher
Lee S, Bae G, Kim Y, Kim H, Lee M, Ghim J, et al. A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Sci Rep. 2019;9:7242 pubmed publisher
Albeituni S, Verbist K, Tedrick P, Tillman H, Picarsic J, Bassett R, et al. Mechanisms of Action of Ruxolitinib in Murine Models of Hemophagocytic Lymphohistiocytosis. Blood. 2019;: pubmed publisher
Jin C, Lagoudas G, Zhao C, Bullman S, Bhutkar A, Hu B, et al. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. 2019;176:998-1013.e16 pubmed publisher
Chinta K, Rahman M, Saini V, Glasgow J, Reddy V, Lever J, et al. Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis. Cell Rep. 2018;25:1938-1952.e5 pubmed publisher
Ramani K, Jawale C, Verma A, Coleman B, Kolls J, Biswas P. Unexpected kidney-restricted role for IL-17 receptor signaling in defense against systemic Candida albicans infection. JCI Insight. 2018;3: pubmed publisher
Fensterheim B, YOUNG J, Luan L, Kleinbard R, Stothers C, Patil N, et al. The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism. J Immunol. 2018;200:3777-3789 pubmed publisher
Dong B, Tong Z, Li R, Chen S, Liu W, Liu W, et al. Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-γ production. PLoS Negl Trop Dis. 2018;12:e0006237 pubmed publisher
Meisel J, Sfyroera G, Bartow McKenney C, Gimblet C, Bugayev J, Horwinski J, et al. Commensal microbiota modulate gene expression in the skin. Microbiome. 2018;6:20 pubmed publisher
Rayes J, Lax S, Wichaiyo S, Watson S, Di Y, Lombard S, et al. The podoplanin-CLEC-2 axis inhibits inflammation in sepsis. Nat Commun. 2017;8:2239 pubmed publisher
Jones G, Smith V, D Orazio S. Listeria monocytogenes Replicate in Bone Marrow-Derived CD11c+ Cells but Not in Dendritic Cells Isolated from the Murine Gastrointestinal Tract. J Immunol. 2017;199:3789-3797 pubmed publisher
King A, Houlihan D, Kavanagh D, Haldar D, Luu N, Owen A, et al. Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. Gastroenterology. 2017;153:233-248.e16 pubmed publisher
Jones G, D Orazio S. Monocytes Are the Predominant Cell Type Associated with Listeria monocytogenes in the Gut, but They Do Not Serve as an Intracellular Growth Niche. J Immunol. 2017;198:2796-2804 pubmed publisher
Zha Q, Wei H, Li C, Liang Y, Xu L, Bai W, et al. ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages. Front Immunol. 2016;7:597 pubmed publisher
Tian Y, Pan D, Chordia M, French B, Kron I, Yang Z. The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE. Basic Res Cardiol. 2016;111:62 pubmed publisher
Cai Z, Zhang A, Choksi S, Li W, Li T, Zhang X, et al. Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration. Cell Res. 2016;26:886-900 pubmed publisher
Kamenyeva O, Boularan C, Kabat J, Cheung G, Cicala C, Yeh A, et al. Neutrophil recruitment to lymph nodes limits local humoral response to Staphylococcus aureus. PLoS Pathog. 2015;11:e1004827 pubmed publisher
Miura M, Fu X, Zhang Q, Remick D, Fairchild R. Neutralization of Gro alpha and macrophage inflammatory protein-2 attenuates renal ischemia/reperfusion injury. Am J Pathol. 2001;159:2137-45 pubmed
product information
Product Type :
Antibody
Product Name :
Ly-6G Monoclonal Antibody (1A8-Ly6g), Functional Grade, eBioscience
Catalog # :
16-9668-85
Quantity :
500 µg
Price :
US 359.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: 0.25 µg/test, Functional Assay: Assay-Dependent
Species :
Mouse
Clone :
1A8-Ly6g
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
Ly6G (Lymphocyte antigen 6 complex locus G6D) is a component of the myeloid differentiation antigen Gr-1, together with Ly6C. The Ly6G protein has a molecular weight of approximately 21-25 kDa and is expressed by myeloid derived cells in the bone marrow. Ly6G is a good marker for detection of peripheral neutrophils, monocytes and granulocytes. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. The physiological role of Ly6G remains unclear but studies have shown its involvement in anti-tumor response, and studies with neutrophils suggest that Ly6G ligation may have an inhibitory effect on local immune responses.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 0.25 µg/test, Functional Assay: Assay-Dependent
Aliases :
Gr1; Gr-1; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6G
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA