This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TNF alpha Monoclonal Antibody (TN3-19.12), Functional Grade, eBioscience
catalog :
16-7423-85
quantity :
500 ug
price :
US 368.00
clonality :
monoclonal
host :
hamsters
conjugate :
nonconjugated
clone name :
TN3-19.12

The same clone is also sold as:
reactivity :
mouse, rat
application :
neutralization
citations: 29
Reference
Yang B, Yang L, Wang Y, Maddison L, Tang Z, Haigh S, et al. Macrophages and neutrophils are necessary for ER stress-induced β cell loss. Cell Rep. 2022;40:111255 pubmed publisher
Tang T, Huang X, Zhang G, Lu M, Hong Z, Wang M, et al. Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis. J Immunother Cancer. 2022;10: pubmed publisher
Lin Q, Rong L, Jia X, Li R, Yu B, Hu J, et al. IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella. Nat Commun. 2021;12:2537 pubmed publisher
Noguchi J, Ikeda M, Kikuchi K, Dang Nguyen T, Kasashima M, Tatematsu K, et al. Successful activation of rat T lymphocytes by sperm specific antigens in vitro. J Reprod Dev. 2020;66:599-605 pubmed publisher
Ma L, Jiang Y, Dong Y, Gao J, Du B, Liu D. Anti-TNF-alpha antibody attenuates subarachnoid hemorrhage-induced apoptosis in the hypothalamus by inhibiting the activation of Erk. Neuropsychiatr Dis Treat. 2018;14:525-536 pubmed publisher
Wang Q, Ning H, Peng H, Wei L, Hou R, Hoft D, et al. Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses. Nat Commun. 2017;8:867 pubmed publisher
Sakurai T, Kashida H, Watanabe T, Hagiwara S, Mizushima T, Iijima H, et al. Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. Cancer Res. 2014;74:6119-28 pubmed publisher
Ho P, Meeth K, Tsui Y, Srivastava B, Bosenberg M, Kaech S. Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFN?. Cancer Res. 2014;74:3205-17 pubmed publisher
Johnson R, Kerr M, Slaven J. An atypical CD8 T-cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin-13. Immunology. 2014;142:248-57 pubmed publisher
Parlet C, Schlueter A. Mechanisms by which chronic ethanol feeding impairs the migratory capacity of cutaneous dendritic cells. Alcohol Clin Exp Res. 2013;37:2098-107 pubmed publisher
Sakamoto T, Takahashi N, Sawaragi Y, Naknukool S, Yu R, Goto T, et al. Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes. Am J Physiol Cell Physiol. 2013;304:C729-38 pubmed publisher
Park S, Kang S, Min K, Woo Hwang K, Min H. Age-associated changes in microRNA expression in bone marrow derived dendritic cells. Immunol Invest. 2013;42:179-90 pubmed publisher
Enwere E, Holbrook J, Lejmi Mrad R, Vineham J, Timusk K, Sivaraj B, et al. TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-?B signaling pathway. Sci Signal. 2012;5:ra75 pubmed publisher
Glowacka W, Alberts P, Ouchida R, Wang J, Rotin D. LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages. J Biol Chem. 2012;287:27691-702 pubmed publisher
Gilbert M, Wagner N, Jones S, Wisz A, Roques J, Krum K, et al. Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages. J Immunol. 2012;189:711-20 pubmed publisher
Morse M, McNeel D. T cells localized to the androgen-deprived prostate are TH1 and TH17 biased. Prostate. 2012;72:1239-47 pubmed publisher
Nesterovitch A, Szanto S, Gonda A, Bardos T, Kis Toth K, Adarichev V, et al. Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans. Am J Pathol. 2011;178:1701-14 pubmed publisher
Propst K, Troyer R, Kellihan L, Schweizer H, Dow S. Immunotherapy markedly increases the effectiveness of antimicrobial therapy for treatment of Burkholderia pseudomallei infection. Antimicrob Agents Chemother. 2010;54:1785-92 pubmed publisher
Braun R, Molitor Dart M, Wigfield C, Xiang Z, Fain S, Jankowska Gan E, et al. Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection. Transplantation. 2009;88:1341-8 pubmed publisher
Massilamany C, Steffen D, Reddy J. An epitope from Acanthamoeba castellanii that cross-react with proteolipid protein 139-151-reactive T cells induces autoimmune encephalomyelitis in SJL mice. J Neuroimmunol. 2010;219:17-24 pubmed publisher
Niikura M, Kamiya S, Nakane A, Kita K, Kobayashi F. IL-10 plays a crucial role for the protection of experimental cerebral malaria by co-infection with non-lethal malaria parasites. Int J Parasitol. 2010;40:101-8 pubmed publisher
Fang C, Zhang X, Miwa T, Song W. Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production. Blood. 2009;114:1005-15 pubmed publisher
Troyer R, Propst K, Fairman J, Bosio C, Dow S. Mucosal immunotherapy for protection from pneumonic infection with Francisella tularensis. Vaccine. 2009;27:4424-33 pubmed publisher
Goodyear A, Kellihan L, Bielefeldt Ohmann H, Troyer R, Propst K, Dow S. Protection from pneumonic infection with burkholderia species by inhalational immunotherapy. Infect Immun. 2009;77:1579-88 pubmed publisher
Ou R, Zhang M, Huang L, Moskophidis D. Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection. J Virol. 2008;82:3353-68 pubmed publisher
Hager E, Tse H, Piganelli J, Gupta M, Baetscher M, Tse T, et al. Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome. J Inherit Metab Dis. 2007;30:888-95 pubmed
Blumberg H, Dinh H, Trueblood E, Pretorius J, Kugler D, Weng N, et al. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J Exp Med. 2007;204:2603-14 pubmed
Jung I, Lee J, Kim Y, Jeong Y, Lee C, Lee M, et al. Sphingosine kinase inhibitor suppresses dendritic cell migration by regulating chemokine receptor expression and impairing p38 mitogen-activated protein kinase. Immunology. 2007;121:533-44 pubmed
Uno J, Kolek O, Hines E, Xu H, Timmermann B, Kiela P, et al. The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis. Gastroenterology. 2006;131:497-509 pubmed
product information
Product Type :
Antibody
Product Name :
TNF alpha Monoclonal Antibody (TN3-19.12), Functional Grade, eBioscience
Catalog # :
16-7423-85
Quantity :
500 ug
Price :
US 368.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Armenian Hamster
Reactivity :
Mouse, Rat
Applications :
Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Species :
Mouse, Rat
Clone :
TN3-19.12
Isotype :
IgG
Storage :
4 C
Description :
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Format :
Liquid
Applications w/Dilutions :
Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Aliases :
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA