GM-CSF Monoclonal Antibody (MP1-22E9), Functional Grade, eBioscience | Invitrogen 16-7331-025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GM-CSF Monoclonal Antibody (MP1-22E9), Functional Grade, eBioscience

catalog :

16-7331-025

quantity :

25 mg

price :

US 8250

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MP1-22E9

reactivity :

mouse

application :

neutralization, flow cytometry

citations: 11

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse; loading ...; fig 7d	Akgul A, Maddaloni M, Jun S, Nelson A, Odreman V, Hoffman C, et al. Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome. Arthritis Res Ther. 2021;23:99 pubmed publisher
flow cytometry; mouse; loading ...	Hamminger P, Marchetti L, Preglej T, Platzer R, Zhu C, Kamnev A, et al. Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. J Autoimmun. 2021;119:102610 pubmed publisher
	Spiljar M, Steinbach K, Rigo D, Su xe1 rez Zamorano N, Wagner I, Hadadi N, et al. Cold exposure protects from neuroinflammation through immunologic reprogramming. Cell Metab. 2021;33:2231-2246.e8 pubmed publisher
	Hauptmann J, Johann L, Marini F, Kitic M, Colombo E, Mufazalov I, et al. Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood-brain barrier. Acta Neuropathol. 2020;140:549-567 pubmed publisher
	Wildes T, Grippin A, Dyson K, Wummer B, Damiani D, Abraham R, et al. Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma. Clin Cancer Res. 2018;24:3955-3966 pubmed publisher
	Dalmas E, Lehmann F, Dror E, Wueest S, Thienel C, Borsigova M, et al. Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production. Immunity. 2017;47:928-942.e7 pubmed publisher
	Wang J, De Veirman K, De Beule N, Maes K, De Bruyne E, Van Valckenborgh E, et al. The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells. Oncotarget. 2015;6:43992-4004 pubmed publisher
	Huen S, Huynh L, Marlier A, Lee Y, Moeckel G, Cantley L. GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol. 2015;26:1334-45 pubmed publisher
	Suzuki T, Arumugam P, Sakagami T, Lachmann N, Chalk C, Sallese A, et al. Pulmonary macrophage transplantation therapy. Nature. 2014;514:450-4 pubmed publisher
	Robbins C, Hilgendorf I, Weber G, Theurl I, Iwamoto Y, Figueiredo J, et al. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med. 2013;19:1166-72 pubmed publisher
	Nijnik A, Madera L, Ma S, Waldbrook M, Elliott M, Easton D, et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. 2010;184:2539-50 pubmed publisher

product information

Product Type :

Antibody

Product Name :

GM-CSF Monoclonal Antibody (MP1-22E9), Functional Grade, eBioscience

Catalog # :

16-7331-025

Quantity :

25 mg

Price :

US 8250

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: 1.25 µg/mL, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

MP1-22E9

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombinant GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).

Format :

Liquid

Applications w/Dilutions :

ELISA: 1.25 µg/mL, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

colony stimulating factor 2; colony stimulating factor 2 (granulocyte-macrophage); colony-stimulating factor; CSF; CSF2; Csfgm; cytokine; GMCSF; Gm-CSf; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; granulocyte-macrophage colony stimulating factor 2; granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; MGC151255; MGC151257; MGI-IGM; M-GM-CSF; molgramostin; put. GM-CSF; sargramostim