TNF alpha Monoclonal Antibody (MP6-XT3), Functional Grade, eBioscience | Invitrogen 16-7322-81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TNF alpha Monoclonal Antibody (MP6-XT3), Functional Grade, eBioscience

catalog :

16-7322-81

quantity :

50 µg

price :

US 121

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MP6-XT3

reactivity :

mouse

application :

neutralization

citations: 26

Reference
Birkl D, Quirós M, García Hernández V, Zhou D, Brazil J, Hilgarth R, et al. TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epithelium. Mucosal Immunol. 2019;: pubmed publisher
Finsterwalder R, Ganesan M, Leb H, Habertheuer A, Basílio J, Lang I, et al. Hypoxia/reperfusion predisposes to atherosclerosis. PLoS ONE. 2018;13:e0205067 pubmed publisher
Linz B, Neely C, Kartchner L, Mendoza A, Khoury A, Truax A, et al. Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis. J Immunol. 2017;198:2426-2433 pubmed publisher
Martínez Gómez J, Ong L, Lam J, Binte Aman S, Libau E, Lee P, et al. Maternal Antibody-Mediated Disease Enhancement in Type I Interferon-Deficient Mice Leads to Lethal Disease Associated with Liver Damage. PLoS Negl Trop Dis. 2016;10:e0004536 pubmed publisher
Phanthanawiboon S, Limkittikul K, Sakai Y, Takakura N, Saijo M, Kurosu T. Acute Systemic Infection with Dengue Virus Leads to Vascular Leakage and Death through Tumor Necrosis Factor-α and Tie2/Angiopoietin Signaling in Mice Lacking Type I and II Interferon Receptors. PLoS ONE. 2016;11:e0148564 pubmed publisher
Sarathy V, Infante E, Li L, Campbell G, Wang T, Paessler S, et al. Characterization of lethal dengue virus type 4 (DENV-4) TVP-376 infection in mice lacking both IFN-?/? and IFN-? receptors (AG129) and comparison with the DENV-2 AG129 mouse model. J Gen Virol. 2015;96:3035-48 pubmed publisher
Arnold I, Hutchings C, Kondova I, Hey A, Powrie F, Beverley P, et al. Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis. Vaccine. 2015;33:1808-14 pubmed publisher
Sarathy V, White M, Li L, Gorder S, Pyles R, Campbell G, et al. A lethal murine infection model for dengue virus 3 in AG129 mice deficient in type I and II interferon receptors leads to systemic disease. J Virol. 2015;89:1254-66 pubmed publisher
Arnold J, Magiera L, Kraman M, Fearon D. Tumoral immune suppression by macrophages expressing fibroblast activation protein-Î± and heme oxygenase-1. Cancer Immunol Res. 2014;2:121-6 pubmed publisher
Ng J, Zhang S, Tan H, Yan B, Martinez J, Tan W, et al. First experimental in vivo model of enhanced dengue disease severity through maternally acquired heterotypic dengue antibodies. PLoS Pathog. 2014;10:e1004031 pubmed publisher
Van De Voort T, Felder M, Yang R, Sondel P, Rakhmilevich A. Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice. J Immunother. 2013;36:29-40 pubmed publisher
Montinaro A, Forte G, Sorrentino R, Luciano A, Palma G, Arra C, et al. Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice. PLoS ONE. 2012;7:e45401 pubmed publisher
Kukita A, Ichigi Y, Takigawa I, Watanabe T, Kukita T, Miyamoto H. Infection of RANKL-primed RAW-D macrophages with Porphyromonas gingivalis promotes osteoclastogenesis in a TNF-?-independent manner. PLoS ONE. 2012;7:e38500 pubmed publisher
Helmersson S, Stenstrom M, Leanderson T, Ivars F. Specific effect of immunomodulatory quinoline-3-carboxamide ABR-215757 in GM-CSF stimulated bone marrow cell cultures: block of initiation of proliferation of Gr-1+ cells. Int Immunopharmacol. 2011;11:1045-51 pubmed publisher
Hou X, Zhou R, Wei H, Sun R, Tian Z. NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. Hepatology. 2009;49:940-9 pubmed publisher
Prestwood T, Prigozhin D, Sharar K, Zellweger R, Shresta S. A mouse-passaged dengue virus strain with reduced affinity for heparan sulfate causes severe disease in mice by establishing increased systemic viral loads. J Virol. 2008;82:8411-21 pubmed publisher
Castilow E, Olson M, Meyerholz D, Varga S. Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus. J Virol. 2008;82:2196-207 pubmed
LeibundGut Landmann S, Gross O, Robinson M, Osorio F, Slack E, Tsoni S, et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol. 2007;8:630-8 pubmed
Zhou R, Wei H, Sun R, Tian Z. Recognition of double-stranded RNA by TLR3 induces severe small intestinal injury in mice. J Immunol. 2007;178:4548-56 pubmed
Chen H, Hofman F, Kung J, Lin Y, Wu Hsieh B. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol. 2007;81:5518-26 pubmed
Shresta S, Sharar K, Prigozhin D, Beatty P, Harris E. Murine model for dengue virus-induced lethal disease with increased vascular permeability. J Virol. 2006;80:10208-17 pubmed
Chassin C, Goujon J, Darche S, du Merle L, Bens M, Cluzeaud F, et al. Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways. J Immunol. 2006;177:4773-84 pubmed
Chackerian B, Lowy D, Schiller J. Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies. J Clin Invest. 2001;108:415-23 pubmed
Hunter C, Litton M, Remington J, Abrams J. Immunocytochemical detection of cytokines in the lymph nodes and brains of mice resistant or susceptible to toxoplasmic encephalitis. J Infect Dis. 1994;170:939-45 pubmed
Litton M, Sander B, Murphy E, O GARRA A, Abrams J. Early expression of cytokines in lymph nodes after treatment in vivo with Staphylococcus enterotoxin B. J Immunol Methods. 1994;175:47-58 pubmed
Abrams J, Roncarolo M, Yssel H, Andersson U, Gleich G, Silver J. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev. 1992;127:5-24 pubmed

product information

Product Type :

Antibody

Product Name :

TNF alpha Monoclonal Antibody (MP6-XT3), Functional Grade, eBioscience

Catalog # :

16-7322-81

Quantity :

50 µg

Price :

US 121

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

MP6-XT3

Isotype :

IgG1, kappa

Storage :

4° C

Description :

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor