This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-23 p19 Monoclonal Antibody (G23-8), Functional Grade, eBioscience
catalog :
16-7232-025
quantity :
25 mg
price :
US 9300.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
G23-8

The same clone is also sold as:
reactivity :
mouse
application :
western blot, ELISA, neutralization
citations: 5
Reference
Koh J, Kim H, Lee Y, Park I, Kang C, Kim Y, et al. IL23-Producing Human Lung Cancer Cells Promote Tumor Growth via Conversion of Innate Lymphoid Cell 1 (ILC1) into ILC3. Clin Cancer Res. 2019;: pubmed publisher
Mathur R, Alam M, Zhao X, Liao Y, Shen J, Morgan S, et al. Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis. Mucosal Immunol. 2019;12:612-623 pubmed publisher
Wang B, Lim J, Kajikawa T, Li X, Vallance B, Moutsopoulos N, et al. Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis. Cell Rep. 2019;26:1614-1626.e5 pubmed publisher
Gómez Samblás M, Bernal D, Bolado Ortiz A, Vilchez S, Bolas Fernandez F, Espino A, et al. Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice. Sci Rep. 2018;8:7787 pubmed publisher
Takenaka N, Edamatsu H, Suzuki N, Saito H, Inoue Y, Oka M, et al. Overexpression of phospholipase C? in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration. Eur J Immunol. 2011;41:202-13 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-23 p19 Monoclonal Antibody (G23-8), Functional Grade, eBioscience
Catalog # :
16-7232-025
Quantity :
25 mg
Price :
US 9300.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
ELISA: 1.25 ug/mL, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent
Species :
Mouse
Clone :
G23-8
Isotype :
IgG1, kappa
Storage :
4 C
Description :
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN- . Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN- production by naive and memory T cells, as compared to IL-12.
Format :
Liquid
Applications w/Dilutions :
ELISA: 1.25 ug/mL, Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent, Western Blot: Assay-Dependent
Aliases :
il 23; IL 23 A; IL12B; Il-12b; Il12p40; Il-12p40; il23; IL-23; IL-23 subunit alpha; IL23A; IL-23A; IL-23-A; IL23P19; IL-23p19; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; Interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; p40; RP23-388G23.1; SGRF; UNQ2498/PRO5798
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA