IL-21 Monoclonal Antibody (FFA21), Functional Grade, eBioscience | Invitrogen 16-7211-85 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-21 Monoclonal Antibody (FFA21), Functional Grade, eBioscience

catalog :

16-7211-85

quantity :

500 µg

price :

US 461

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

FFA21

reactivity :

mouse

application :

neutralization, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; mouse	Vegran F, Berger H, Boidot R, Mignot G, Bruchard M, Dosset M, et al. The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells. Nat Immunol. 2014;15:758-66 pubmed publisher
	Wei H, Jin C, Peng A, Xie H, Xie S, Feng Y, et al. Characterization of γδT cells in lung of Plasmodium yoelii-infected C57BL/6 mice. Malar J. 2021;20:89 pubmed publisher
	Djokić V, Primus S, Akoolo L, Chakraborti M, Parveen N. Age-Related Differential Stimulation of Immune Response by Babesia microti and Borrelia burgdorferi During Acute Phase of Infection Affects Disease Severity. Front Immunol. 2018;9:2891 pubmed publisher
	Rezende R, Lanser A, Rubino S, Kuhn C, Skillin N, Moreira T, et al. γδ T cells control humoral immune response by inducing T follicular helper cell differentiation. Nat Commun. 2018;9:3151 pubmed publisher
	Shen Z, Yang H, Yang S, Wang W, Cui X, Zhou X, et al. Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance. Nat Commun. 2017;8:2119 pubmed publisher
	Li B, Wang X, Choi I, Wang Y, Liu S, Pham A, et al. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017;127:3702-3716 pubmed publisher
	Nadya N, Tezuka H, Ohteki T, Matsuda S, Azuma M, Nagai S. PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells. Immunology. 2017;152:507-516 pubmed publisher
	Shao L, Lie A, Zhang Y, Wong C, Kwong Y. Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease. Ann Hematol. 2015;94:1493-504 pubmed publisher
	Hashimoto Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, et al. Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2015;112:E2677-86 pubmed publisher
	Sage P, Alvarez D, Godec J, von Andrian U, Sharpe A. Circulating T follicular regulatory and helper cells have memory-like properties. J Clin Invest. 2014;124:5191-204 pubmed publisher
	Cedeno Laurent F, Opperman M, Barthel S, Kuchroo V, Dimitroff C. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012;188:3127-37 pubmed publisher
	Eto D, LAO C, DiToro D, Barnett B, Escobar T, Kageyama R, et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS ONE. 2011;6:e17739 pubmed publisher
	Doisne J, Soulard V, Becourt C, Amniai L, Henrot P, Havenar Daughton C, et al. Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol. 2011;186:662-6 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IL-21 Monoclonal Antibody (FFA21), Functional Grade, eBioscience

Catalog # :

16-7211-85

Quantity :

500 µg

Price :

US 461

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Species :

Mouse

Clone :

FFA21

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.

Format :

Liquid

Applications w/Dilutions :

Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent

Aliases :

CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11

more info or order :

Invitrogen product webpage