product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-17A Monoclonal Antibody (eBio64CAP17), Functional Grade, eBioscience
catalog :
16-7178-81
quantity :
50 µg
price :
US 131
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
eBio64CAP17
reactivity :
African green monkey, human, mouse, rhesus macaque
application :
ELISA, immunohistochemistry, neutralization, flow cytometry
more info or order :
citations: 95
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...
Nian Y, Iske J, Maenosono R, Minami K, Heinbokel T, Quante M, et al. Targeting age-specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival. Aging Cell. 2021;20:e13299 pubmed publisher
  • flow cytometry; human; loading ...; fig s4c
Boutboul D, Kuehn H, Van de Wyngaert Z, Niemela J, Callebaut I, Stoddard J, et al. Dominant-negative IKZF1 mutations cause a T, B, and myeloid cell combined immunodeficiency. J Clin Invest. 2018;128:3071-3087 pubmed publisher
  • flow cytometry; human; 1:100; fig 5h
Hsieh W, Hsu T, Chang Y, Lai M. IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. Nat Commun. 2018;9:463 pubmed publisher
  • flow cytometry; African green monkey; loading ...; fig 1e
Neumann B, Shi T, Gan L, Klippert A, Daskalaki M, Stolte Leeb N, et al. Comprehensive panel of cross-reacting monoclonal antibodies for analysis of different immune cells and their distribution in the common marmoset (Callithrix jacchus). J Med Primatol. 2016;45:139-46 pubmed publisher
  • flow cytometry; rhesus macaque; fig 1b
Rueda C, Presicce P, Jackson C, Miller L, Kallapur S, Jobe A, et al. Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque. J Immunol. 2016;196:3706-15 pubmed publisher
  • flow cytometry; human
Kamburova E, Koenen H, van den Hoogen M, Baas M, Joosten I, Hilbrands L. Longitudinal analysis of T and B cell phenotype and function in renal transplant recipients with or without rituximab induction therapy. PLoS ONE. 2014;9:e112658 pubmed publisher
  • ELISA; human; 1:1000
Vogelpoel L, Hansen I, Rispens T, Muller F, van Capel T, Turina M, et al. Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages. Nat Commun. 2014;5:5444 pubmed publisher
  • flow cytometry; human
Kagina B, Tameris M, Geldenhuys H, Hatherill M, Abel B, Hussey G, et al. The novel tuberculosis vaccine, AERAS-402, is safe in healthy infants previously vaccinated with BCG, and induces dose-dependent CD4 and CD8T cell responses. Vaccine. 2014;32:5908-17 pubmed publisher
  • flow cytometry; human; loading ...; fig 1d
Lutwama F, Kagina B, Wajja A, Waiswa F, Mansoor N, Kirimunda S, et al. Distinct T-cell responses when BCG vaccination is delayed from birth to 6 weeks of age in Ugandan infants. J Infect Dis. 2014;209:887-97 pubmed publisher
  • flow cytometry; African green monkey; loading ...; fig s1c
Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed publisher
  • flow cytometry; human; 1:50; fig 1
Wolff M, Leung J, Davenport M, Poles M, Cho I, Loke P. TH17, TH22 and Treg cells are enriched in the healthy human cecum. PLoS ONE. 2012;7:e41373 pubmed publisher
  • flow cytometry; rhesus macaque
  • immunohistochemistry; rhesus macaque
Klatt N, Estes J, Sun X, Ortiz A, Barber J, Harris L, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 2012;5:646-57 pubmed publisher
  • flow cytometry; human
Hunter P, Nistala K, Jina N, Eddaoudi A, Thomson W, Hubank M, et al. Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression. Arthritis Rheum. 2010;62:896-907 pubmed publisher
Chang G, Yang X, Liu W, Lin S, Yang S, Zhao M. FABP4 facilitates inflammasome activation to induce the Treg/Th17 imbalance in preeclampsia via forming a positive feedback with IL-17A. Mol Ther Nucleic Acids. 2021;24:743-754 pubmed publisher
Zu J, Yao L, Song Y, Cui Y, Guan M, Chen R, et al. Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa. Front Immunol. 2020;11:570888 pubmed publisher
Crawford M, Sinha S, Renavikar P, Borcherding N, Karandikar N. CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression. Proc Natl Acad Sci U S A. 2020;117:19408-19414 pubmed publisher
Chang S, Kim H, Park C. Allogeneic ADSCs Induce the Production of Alloreactive Memory-CD8 T Cells through HLA-ABC Antigens. Cells. 2020;9: pubmed publisher
Wang J, Li C, Fu J, Wang X, Feng X, Pan X. Tim-3 regulates inflammatory cytokine expression and Th17 cell response induced by monocytes from patients with chronic hepatitis B. Scand J Immunol. 2019;89:e12755 pubmed publisher
Baglaenko Y, Chang N, Johnson S, Hafiz W, Manion K, Ferri D, et al. The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease. Arthritis Res Ther. 2018;20:264 pubmed publisher
Pan D, Das A, Srivastav S, Traina Dorge V, Didier P, Pahar B. Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection. J Gen Virol. 2019;100:26-34 pubmed publisher
D Addio F, Vergani A, Potena L, Maestroni A, Usuelli V, Ben Nasr M, et al. P2X7R mutation disrupts the NLRP3-mediated Th program and predicts poor cardiac allograft outcomes. J Clin Invest. 2018;128:3490-3503 pubmed publisher
Kebir H, Carmant L, Fontaine F, Beland K, Bosoi C, Sanon N, et al. Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis. J Clin Invest. 2018;128:2000-2009 pubmed publisher
Tedesco D, Thapa M, Chin C, Ge Y, Gong M, Li J, et al. Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease. Gastroenterology. 2018;154:2178-2193 pubmed publisher
Dillen C, Pinsker B, Marusina A, Merleev A, Farber O, Liu H, et al. Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection. J Clin Invest. 2018;128:1026-1042 pubmed publisher
Baguma R, Penn Nicholson A, Smit E, Erasmus M, Day J, Makhethe L, et al. Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population. PLoS ONE. 2017;12:e0184563 pubmed publisher
Wu Q, Wang Q, Mao G, Dowling C, Lundy S, Mao Draayer Y. Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients. J Immunol. 2017;198:3069-3080 pubmed publisher
Franchi L, Monteleone I, Hao L, Spahr M, Zhao W, Liu X, et al. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis. J Immunol. 2017;198:2735-2746 pubmed publisher
Hippen K, Watkins B, Tkachev V, Lemire A, Lehnen C, Riddle M, et al. Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease. Transplantation. 2016;100:2630-2639 pubmed publisher
Sullivan J, Jankowska Gan E, Hegde S, Pestrak M, Agashe V, Park A, et al. Th17 Responses to Collagen Type V, kα1-Tubulin, and Vimentin Are Present Early in Human Development and Persist Throughout Life. Am J Transplant. 2017;17:944-956 pubmed publisher
Liang D, Hou Y, Luo L, Ao L. Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. Int J Mol Med. 2016;38:131-8 pubmed publisher
Fu D, Song X, Hu H, Sun M, Li Z, Tian Z. Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis. Mol Med Rep. 2016;13:4606-12 pubmed publisher
Kim J, Bae S, Song S, Chung K, Kwon S. Fiber composite slices for multiplexed immunoassays. Biomicrofluidics. 2015;9:044109 pubmed publisher
Sullivan J, Jankowska Gan E, Shi L, Roenneburg D, Hegde S, Greenspan D, et al. Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses. Am J Transplant. 2014;14:1512-22 pubmed publisher
Shanmugasundaram U, Critchfield J, Pannell J, Perry J, Giudice L, Smith McCune K, et al. Phenotype and functionality of CD4+ and CD8+ T cells in the upper reproductive tract of healthy premenopausal women. Am J Reprod Immunol. 2014;71:95-108 pubmed publisher
Kim K, Srikanth S, Tan Y, Yee M, Jew M, Damoiseaux R, et al. Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014;192:110-22 pubmed publisher
Van Rompay K, Hunter Z, Jayashankar K, Peabody J, Montefiori D, LaBranche C, et al. A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251. J Virol. 2014;88:2011-24 pubmed publisher
Cornwell W, Lewis M, Fan X, Rappaport J, Rogers T. Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques. J Neuroimmunol. 2013;265:43-50 pubmed publisher
Zhang W, Nie L, Wang Y, Wang X, Zhao H, Dongol S, et al. CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues. PLoS ONE. 2013;8:e66286 pubmed publisher
Nanzer A, Chambers E, Ryanna K, Richards D, Black C, Timms P, et al. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1?,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol. 2013;132:297-304.e3 pubmed publisher
Liu C, Xia X, Wu W, Wu R, Tang M, Chen T, et al. Anti-tumour necrosis factor therapy enhances mucosal healing through down-regulation of interleukin-21 expression and T helper type 17 cell infiltration in Crohn's disease. Clin Exp Immunol. 2013;173:102-11 pubmed publisher
Kamburova E, Koenen H, Borgman K, ten Berge I, Joosten I, Hilbrands L. A single dose of rituximab does not deplete B cells in secondary lymphoid organs but alters phenotype and function. Am J Transplant. 2013;13:1503-11 pubmed publisher
Lin W, Vilalta A, Adams R, Rolland A, Sullivan S, Griffin D. Vaxfectin adjuvant improves antibody responses of juvenile rhesus macaques to a DNA vaccine encoding the measles virus hemagglutinin and fusion proteins. J Virol. 2013;87:6560-8 pubmed publisher
Xu H, Feely S, Wang X, Liu D, Borda J, Dufour J, et al. Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease. Clin Immunol. 2013;147:40-49 pubmed publisher
Olsen I, Sollid L. Pitfalls in determining the cytokine profile of human T cells. J Immunol Methods. 2013;390:106-12 pubmed publisher
Drewniak A, Gazendam R, Tool A, van Houdt M, Jansen M, van Hamme J, et al. Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. Blood. 2013;121:2385-92 pubmed publisher
Marin N, Paris S, Rojas M, Garcia L. Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB. Tuberculosis (Edinb). 2013;93:155-66 pubmed publisher
Cosgrove C, Ussher J, Rauch A, Gärtner K, Kurioka A, Hühn M, et al. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood. 2013;121:951-61 pubmed publisher
Bahr F, Wehner R, Platzbecker U, Wermke M, Shayegi N, Middeke J, et al. Reconstitution of interleukin-17-producing T helper cells after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2013;19:357-65 pubmed publisher
Dutra M, Béla S, Peixoto Rangel A, Fakiola M, Cruz A, Gazzinelli A, et al. Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis. J Infect Dis. 2013;207:152-63 pubmed publisher
Jonker M, Wubben J, Haanstra K, Vierboom M, t Hart B. Comparative analysis of inflammatory infiltrates in collagen-induced arthritis, kidney graft rejection and delayed-type hypersensitivity in non-human primates. Inflamm Res. 2013;62:181-94 pubmed publisher
Krebs R, Tikkanen J, Ropponen J, Jeltsch M, Jokinen J, Yla Herttuala S, et al. Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis. Am J Pathol. 2012;181:1607-20 pubmed publisher
Jasny E, Geer S, Frank I, Vagenas P, Aravantinou M, Salazar A, et al. Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy. J Acquir Immune Defic Syndr. 2012;61:425-35 pubmed publisher
Ryan Payseur B, Frencher J, Shen L, Chen C, Huang D, Chen Z. Multieffector-functional immune responses of HMBPP-specific V?2V?2 T cells in nonhuman primates inoculated with Listeria monocytogenes ?actA prfA*. J Immunol. 2012;189:1285-93 pubmed publisher
Xu H, Wang X, Liu D, Moroney Rasmussen T, Lackner A, Veazey R. IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques. Mucosal Immunol. 2012;5:658-69 pubmed publisher
Chen C, Huang D, Yao S, Halliday L, Zeng G, Wang R, et al. IL-2 simultaneously expands Foxp3+ T regulatory and T effector cells and confers resistance to severe tuberculosis (TB): implicative Treg-T effector cooperation in immunity to TB. J Immunol. 2012;188:4278-88 pubmed publisher
Jurado J, Pasquinelli V, Alvarez I, Peña D, Rovetta A, Tateosian N, et al. IL-17 and IFN-? expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease. J Leukoc Biol. 2012;91:991-1002 pubmed publisher
Stepanova H, Mensikova M, Chlebova K, Faldyna M. CD4+ and ??TCR+ T lymphocytes are sources of interleukin-17 in swine. Cytokine. 2012;58:152-7 pubmed publisher
Kenna T, Davidson S, Duan R, Bradbury L, McFarlane J, Smith M, et al. Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive ?/? T cells in patients with active ankylosing spondylitis. Arthritis Rheum. 2012;64:1420-9 pubmed publisher
de Wit J, Souwer Y, van Beelen A, De Groot R, Muller F, Klaasse Bos H, et al. CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation. Blood. 2011;118:6107-14 pubmed publisher
Ryan Payseur B, Ali Z, Huang D, Chen C, Yan L, Wang R, et al. Virus infection stages and distinct Th1 or Th17/Th22 T-cell responses in malaria/SHIV coinfection correlate with different outcomes of disease. J Infect Dis. 2011;204:1450-62 pubmed publisher
Gehring A, Koh S, Chia A, Paramasivam K, Chew V, Ho Z, et al. Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. PLoS ONE. 2011;6:e23330 pubmed publisher
Lee J, Chang Y, Lai W, Ko J, Kuo M, Chiang C, et al. Increased prevalence of interleukin-17-producing CD4(+) tumor infiltrating lymphocytes in human oral squamous cell carcinoma. Head Neck. 2011;33:1301-8 pubmed publisher
Morbach H, Wiegering V, Richl P, Schwarz T, Suffa N, Eichhorn E, et al. Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis. Arthritis Rheum. 2011;63:3458-66 pubmed publisher
Tjin E, Konijnenberg D, Krebbers G, Mallo H, Drijfhout J, Franken K, et al. T-cell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: implications for immunotherapy. Clin Cancer Res. 2011;17:5736-47 pubmed publisher
Demberg T, Ettinger A, Aladi S, McKinnon K, Kuddo T, Venzon D, et al. Strong viremia control in vaccinated macaques does not prevent gradual Th17 cell loss from central memory. Vaccine. 2011;29:6017-28 pubmed publisher
Li L, Qiao D, Fu X, Lao S, Zhang X, Wu C. Identification of Mycobacterium tuberculosis-specific Th1, Th17 and Th22 cells using the expression of CD40L in tuberculous pleurisy. PLoS ONE. 2011;6:e20165 pubmed publisher
Li Z, Wu F, Brant S, Kwon J. IL-23 receptor regulation by Let-7f in human CD4+ memory T cells. J Immunol. 2011;186:6182-90 pubmed publisher
Furuzawa Carballeda J, Lima G, Jakez Ocampo J, Llorente L. Indoleamine 2,3-dioxygenase-expressing peripheral cells in rheumatoid arthritis and systemic lupus erythematosus: a cross-sectional study. Eur J Clin Invest. 2011;41:1037-46 pubmed publisher
James E, Van Haren S, Ettinger R, Fijnvandraat K, Liberman J, Kwok W, et al. T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site. J Thromb Haemost. 2011;9:689-99 pubmed publisher
Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D, et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood. 2011;117:1250-9 pubmed publisher
Vagenas P, Aravantinou M, Williams V, Jasny E, Piatak M, Lifson J, et al. A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation. PLoS ONE. 2010;5:e12891 pubmed publisher
DeForge L, Loyet K, Delarosa D, Chinn J, Zamanian F, Chuntharapai A, et al. Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL-17AA, IL-17FF, and IL-17AF. J Immunol Methods. 2010;362:70-81 pubmed publisher
Harris L, Klatt N, Vinton C, Briant J, Tabb B, Ladell K, et al. Mechanisms underlying ?? T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood. 2010;116:4148-57 pubmed publisher
Ikeda U, Wakita D, Ohkuri T, Chamoto K, Kitamura H, Iwakura Y, et al. 1?,25-Dihydroxyvitamin D3 and all-trans retinoic acid synergistically inhibit the differentiation and expansion of Th17 cells. Immunol Lett. 2010;134:7-16 pubmed publisher
Ersvaer E, Liseth K, Skavland J, Gjertsen B, Bruserud Ø. Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol. 2010;11:38 pubmed publisher
Kagina B, Abel B, Scriba T, Hughes E, Keyser A, Soares A, et al. Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns. Am J Respir Crit Care Med. 2010;182:1073-9 pubmed publisher
Ness Schwickerath K, Jin C, Morita C. Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells. J Immunol. 2010;184:7268-80 pubmed publisher
von Vietinghoff S, Ouyang H, Ley K. Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production. Kidney Int. 2010;78:79-88 pubmed publisher
Klatt N, Harris L, Vinton C, Sung H, Briant J, Tabb B, et al. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol. 2010;3:387-98 pubmed publisher
Blatner N, Bonertz A, Beckhove P, Cheon E, Krantz S, Strouch M, et al. In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction. Proc Natl Acad Sci U S A. 2010;107:6430-5 pubmed publisher
Kawamoto K, Pahuja A, Hering B, Bansal Pakala P. Transforming growth factor beta 1 (TGF-beta1) and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs. Transpl Immunol. 2010;23:28-33 pubmed publisher
Yao S, Huang D, Chen C, Halliday L, Zeng G, Wang R, et al. Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis. PLoS Pathog. 2010;6:e1000789 pubmed publisher
Chaudhary N, Staab J, Marr K. Healthy human T-Cell Responses to Aspergillus fumigatus antigens. PLoS ONE. 2010;5:e9036 pubmed publisher
Jeffery L, Burke F, Mura M, Zheng Y, Qureshi O, Hewison M, et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 2009;183:5458-67 pubmed publisher
Kap Y, van Meurs M, van Driel N, Koopman G, Melief M, Brok H, et al. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. J Histochem Cytochem. 2009;57:1159-67 pubmed publisher
van den Boorn J, Konijnenberg D, Dellemijn T, van der Veen J, Bos J, Melief C, et al. Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients. J Invest Dermatol. 2009;129:2220-32 pubmed publisher
Agrati C, Cimini E, Sacchi A, Bordoni V, Gioia C, Casetti R, et al. Activated V gamma 9V delta 2 T cells trigger granulocyte functions via MCP-2 release. J Immunol. 2009;182:522-9 pubmed
Kleinewietfeld M, Starke M, Di Mitri D, Borsellino G, Battistini L, Rotzschke O, et al. CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells. Blood. 2009;113:827-36 pubmed publisher
Roses R, Xu S, Xu M, Koldovsky U, Koski G, Czerniecki B. Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists. J Immunol. 2008;181:5120-7 pubmed
Miyazaki Y, Iwabuchi K, Kikuchi S, Fukazawa T, Niino M, Hirotani M, et al. Expansion of CD4+CD28- T cells producing high levels of interferon-{gamma} in peripheral blood of patients with multiple sclerosis. Mult Scler. 2008;14:1044-55 pubmed publisher
Jasny E, Eisenblatter M, Mätz Rensing K, Tenner Racz K, Tenbusch M, Schrod A, et al. IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation. J Immunol. 2008;180:6629-39 pubmed
Scriba T, Kalsdorf B, Abrahams D, Isaacs F, Hofmeister J, Black G, et al. Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response. J Immunol. 2008;180:1962-70 pubmed
Coury F, Annels N, Rivollier A, Olsson S, Santoro A, Speziani C, et al. Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion. Nat Med. 2008;14:81-7 pubmed
Lim H, Lee J, Hillsamer P, Kim C. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol. 2008;180:122-9 pubmed
Patel D, King C, Bailey S, Holt J, Venkatachalam K, Agrawal A, et al. Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. J Biol Chem. 2007;282:27229-38 pubmed
product information
Product Type :
Antibody
Product Name :
IL-17A Monoclonal Antibody (eBio64CAP17), Functional Grade, eBioscience
Catalog # :
16-7178-81
Quantity :
50 µg
Price :
US 131
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Human
Applications :
Functional Assay: Assay-Dependent, Immunostaining: 0.5-2 µg/mL, Neutralization: Assay-Dependent
Species :
Human
Clone :
eBio64CAP17
Isotype :
IgG1, kappa
Storage :
4° C
Description :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Format :
Liquid
Applications w/Dilutions :
Functional Assay: Assay-Dependent, Immunostaining: 0.5-2 µg/mL, Neutralization: Assay-Dependent
Aliases :
Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA