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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-17A Monoclonal Antibody (eBioMM17F3), Functional Grade, eBioscience
catalog :
16-7173-85
quantity :
500 µg
price :
US 389
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
eBioMM17F3
reactivity :
mouse
application :
neutralization, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 26
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; mouse; fig 1c
Miyajima H, Itokazu T, Tanabe S, Yamashita T. Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice. Cell Death Dis. 2021;12:766 pubmed publisher
  • blocking or activating experiments; mouse; fig 5
Yang L, Cai C, Feng Q, Shi Y, Zuo Q, Yang H, et al. Protective efficacy of the chimeric Staphylococcus aureus vaccine candidate IC in sepsis and pneumonia models. Sci Rep. 2016;6:20929 pubmed publisher
  • blocking or activating experiments; mouse; fig 4
Sell S, Dietz M, Schneider A, Holtappels R, Mach M, Winkler T. Control of murine cytomegalovirus infection by γδ T cells. PLoS Pathog. 2015;11:e1004481 pubmed publisher
Wang Y, Wang X, Li Y, Xue Z, Shao R, Li L, et al. Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway. Pharmacol Res. 2022;176:106083 pubmed publisher
Talbot J, Peres R, Pinto L, Oliveira R, Lima K, Donate P, et al. Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells. Arthritis Res Ther. 2018;20:119 pubmed publisher
Lin W, Wang N, Zhou K, Su F, Jiang Y, Shou J, et al. RKIP mediates autoimmune inflammation by positively regulating IL-17R signaling. EMBO Rep. 2018;19: pubmed publisher
Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, et al. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017;18:586-602 pubmed publisher
Li J, Melton A, Su G, Hamm D, LaFemina M, Howard J, et al. Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome. J Immunol. 2015;195:87-95 pubmed publisher
Yeaman M, Filler S, Chaili S, Barr K, Wang H, Kupferwasser D, et al. Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection. Proc Natl Acad Sci U S A. 2014;111:E5555-63 pubmed publisher
Song L, Weng D, Dai W, Tang W, Chen S, Li C, et al. Th17 can regulate silica-induced lung inflammation through an IL-1?-dependent mechanism. J Cell Mol Med. 2014;18:1773-84 pubmed publisher
Martinez N, Sato F, Kawai E, Omura S, Takahashi S, Yoh K, et al. Th17-biased RORγt transgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav Immun. 2015;43:86-97 pubmed publisher
Hou W, Jin Y, Kang H, Kim B. Interleukin-6 (IL-6) and IL-17 synergistically promote viral persistence by inhibiting cellular apoptosis and cytotoxic T cell function. J Virol. 2014;88:8479-89 pubmed publisher
Tang W, Liu F, Chen Y, Song L, Dai W, Li C, et al. Reduction of IL-17A might suppress the Th1 response and promote the Th2 response by boosting the function of Treg cells during silica-induced inflammatory response in vitro. Mediators Inflamm. 2014;2014:570894 pubmed publisher
Rodrígues Díez R, Aroeira L, Orejudo M, Bajo M, Heffernan J, Rodrigues Díez R, et al. IL-17A is a novel player in dialysis-induced peritoneal damage. Kidney Int. 2014;86:303-15 pubmed publisher
Melillo A, Foreman O, Bosio C, Elkins K. T-bet regulates immunity to Francisella tularensis live vaccine strain infection, particularly in lungs. Infect Immun. 2014;82:1477-90 pubmed publisher
Chen Y, Li C, Weng D, Song L, Tang W, Dai W, et al. Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice. Toxicol Appl Pharmacol. 2014;275:62-72 pubmed publisher
Gatzka M, Hainzl A, Peters T, Singh K, Tasdogan A, Wlaschek M, et al. Reduction of CD18 promotes expansion of inflammatory ?? T cells collaborating with CD4+ T cells in chronic murine psoriasiform dermatitis. J Immunol. 2013;191:5477-88 pubmed publisher
Hansen E, Medic V, Kuo J, Warner T, Schell R, Nardelli D. Interleukin-10 (IL-10) inhibits Borrelia burgdorferi-induced IL-17 production and attenuates IL-17-mediated Lyme arthritis. Infect Immun. 2013;81:4421-30 pubmed publisher
Monteiro M, Almeida C, Agua Doce A, Graca L. Induced IL-17-producing invariant NKT cells require activation in presence of TGF-? and IL-1?. J Immunol. 2013;190:805-11 pubmed publisher
Forte G, Sorrentino R, Montinaro A, Luciano A, Adcock I, Maiolino P, et al. Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma. J Immunol. 2012;189:2226-33 pubmed publisher
Liu S, Wang W, Yen C, Tsai M, Yang P, Wang J, et al. Leukocyte nicotinamide adenine dinucleotide phosphate-reduced oxidase is required for isocyanate-induced lung inflammation. J Allergy Clin Immunol. 2011;127:1014-23 pubmed publisher
Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W. Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy. PLoS ONE. 2010;5:e13349 pubmed publisher
Hou W, Kang H, Kim B. Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J Exp Med. 2009;206:313-28 pubmed publisher
Carlson M, West M, COGHILL J, Panoskaltsis Mortari A, Blazar B, Serody J. In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. Blood. 2009;113:1365-74 pubmed publisher
Song C, Luo L, Lei Z, Li B, Liang Z, Liu G, et al. IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol. 2008;181:6117-24 pubmed
Haworth O, Cernadas M, Yang R, Serhan C, Levy B. Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol. 2008;9:873-9 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-17A Monoclonal Antibody (eBioMM17F3), Functional Grade, eBioscience
Catalog # :
16-7173-85
Quantity :
500 µg
Price :
US 389
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Mouse
Reactivity :
Mouse
Applications :
Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Species :
Mouse
Clone :
eBioMM17F3
Isotype :
IgG1, kappa
Storage :
4° C
Description :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
Format :
Liquid
Applications w/Dilutions :
Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Aliases :
Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA