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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-10 Monoclonal Antibody (JES5-2A5), Functional Grade, eBioscience
catalog :
16-7102-38
quantity :
5 mg
price :
US 2265.00
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
JES5-2A5
reactivity :
mouse
application :
ELISA, neutralization
more info or order :
Invitrogen product webpage
citations: 24
Published Application/Species/Sample/DilutionReference
  • ELISA; mouse; loading ...; fig 5
Akgul A, Maddaloni M, Jun S, Nelson A, Odreman V, Hoffman C, et al. Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome. Arthritis Res Ther. 2021;23:99 pubmed publisher
Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed publisher
Conaway E, de Oliveira D, McInnis C, Snapper S, Horwitz B. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017;198:2906-2915 pubmed publisher
Glenn J, Smith M, Xue P, Chan Li Y, Collins S, Calabresi P, et al. CNS-targeted autoimmunity leads to increased influenza mortality in mice. J Exp Med. 2017;214:297-307 pubmed publisher
Howes A, Taubert C, Blankley S, Spink N, Wu X, Graham C, et al. Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages. J Immunol. 2016;197:2838-53 pubmed publisher
Peda J, Salah S, Wallace D, Fields P, Grantham C, Fields T, et al. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech. 2016;9:1051-61 pubmed publisher
Yao Y, Vent Schmidt J, McGeough M, Wong M, Hoffman H, Steiner T, et al. Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism. J Immunol. 2015;195:488-97 pubmed publisher
Kashi V, Ortega S, Karandikar N. Neuroantigen-specific autoregulatory CD8+ T cells inhibit autoimmune demyelination through modulation of dendritic cell function. PLoS ONE. 2014;9:e105763 pubmed publisher
Mooney J, Butler B, Lokken K, Xavier M, Chau J, Schaltenberg N, et al. The mucosal inflammatory response to non-typhoidal Salmonella in the intestine is blunted by IL-10 during concurrent malaria parasite infection. Mucosal Immunol. 2014;7:1302-11 pubmed publisher
Toda M, Shao Z, Yamaguchi K, Takagi T, D Alessandro Gabazza C, Taguchi O, et al. Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. PLoS ONE. 2013;8:e72392 pubmed publisher
He X, Berland R, Mekasha S, Christensen T, Alroy J, Kramnik I, et al. The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanism. PLoS Pathog. 2013;9:e1003569 pubmed publisher
Mineo S, Niikura M, Inoue S, Kuroda M, Kobayashi F. Development of severe pathology in immunized pregnant mice challenged with lethal malaria parasites. Infect Immun. 2013;81:3865-71 pubmed publisher
Mays L, Ammon Treiber S, Mothes B, Alkhaled M, Rottenberger J, Müller Hermelink E, et al. Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism. J Clin Invest. 2013;123:1216-28 pubmed publisher
Tang G, Zhou H, Xu J, Xu J, Ji M, Wu H, et al. Schistosoma japonicum soluble egg antigens attenuate IFN-?-induced MHC class II expression in RAW 264.7 macrophages. PLoS ONE. 2012;7:e49234 pubmed publisher
Gaddis D, Maynard C, Weaver C, Michalek S, Katz J. Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-? T cell response to Porphyromonas gingivalis. J Leukoc Biol. 2013;93:21-31 pubmed publisher
Silberman D, Bucknum A, Bartlett T, Composto G, Kozlowski M, Walker A, et al. CD28 ligation increases macrophage suppression of T-cell proliferation. Cell Mol Immunol. 2012;9:341-9 pubmed publisher
Hashimoto D, Chow A, Greter M, Saenger Y, Kwan W, Leboeuf M, et al. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med. 2011;208:1069-82 pubmed publisher
Lajoie S, Lewkowich I, Suzuki Y, Clark J, Sproles A, Dienger K, et al. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat Immunol. 2010;11:928-35 pubmed publisher
Nijnik A, Madera L, Ma S, Waldbrook M, Elliott M, Easton D, et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. 2010;184:2539-50 pubmed publisher
Connolly M, Mallen St Clair J, Bedrosian A, Malhotra A, Vera V, Ibrahim J, et al. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. J Leukoc Biol. 2010;87:713-25 pubmed publisher
Jørgensen T, Alfaro J, Enriquez H, Jiang C, Loo W, Atencio S, et al. Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus. J Immunol. 2010;184:775-86 pubmed publisher
Sheng J, Li L, Ganesh B, Prabhakar B, Meriggioli M. Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis. Clin Immunol. 2008;128:172-80 pubmed publisher
Tsuboi Y, Abe H, Nakagawa R, Oomizu S, Watanabe K, Nishi N, et al. Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes. Clin Immunol. 2007;124:221-33 pubmed
Flano E, Kayhan B, Woodland D, Blackman M. Infection of dendritic cells by a gamma2-herpesvirus induces functional modulation. J Immunol. 2005;175:3225-34 pubmed
product information
Product Type :
Antibody
Product Name :
IL-10 Monoclonal Antibody (JES5-2A5), Functional Grade, eBioscience
Catalog # :
16-7102-38
Quantity :
5 mg
Price :
US 2265.00
Clonality :
Monoclonal
Purity :
Affinity chromatography
Host :
Rat
Reactivity :
Mouse
Applications :
Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Species :
Mouse
Clone :
JES5-2A5
Isotype :
IgG1, kappa
Storage :
4 C
Description :
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
Format :
Liquid
Applications w/Dilutions :
Functional Assay: Assay-Dependent, Neutralization: Assay-Dependent
Aliases :
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA